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    SEC24C SEC24 homolog C, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 9632, updated on 2-Aug-2021

    Summary

    Official Symbol
    SEC24Cprovided by HGNC
    Official Full Name
    SEC24 homolog C, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:10705
    See related
    Ensembl:ENSG00000176986 MIM:607185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 30.5), thyroid (RPKM 29.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SEC24C in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (73744164..73772167)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75504130..75531919)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BMS1P4-AGAP5 readthrough Neighboring gene BMS1 pseudogene 4 Neighboring gene RNA, 5S ribosomal pseudogene 320 Neighboring gene glutamate dehydrogenase 1 pseudogene 3 Neighboring gene dual specificity phosphatase 8 pseudogene 5 Neighboring gene uncharacterized LOC107984243 Neighboring gene fucosyltransferase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0079

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SNARE binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COPII vesicle coat NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein transport protein Sec24C
    Names
    SEC24 family, member C
    SEC24 related gene family, member C
    SEC24-related protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004922.4NP_004913.2  protein transport protein Sec24C

      See identical proteins and their annotated locations for NP_004913.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022400, AL596994, BQ710971, CA419040, D38555
      Consensus CDS
      CCDS7332.1
      UniProtKB/Swiss-Prot
      P53992
      UniProtKB/TrEMBL
      A0A024QZM6
      Related
      ENSP00000343405.2, ENST00000339365.2
      Conserved Domains (9) summary
      COG5028
      Location:1811090
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:499758
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:9611036
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:422459
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:847943
      Sec23_helical; Sec23/Sec24 helical domain
      pfam04959
      Location:221306
      ARS2; Arsenite-resistance protein 2
      pfam07001
      Location:142248
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:748831
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11105
      Gly-rich_Ago1; Glycine-rich region of argonaut
    2. NM_198597.3NP_940999.1  protein transport protein Sec24C

      See identical proteins and their annotated locations for NP_940999.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR region, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC022400, AL596994, BC018928, CA419040, D38555
      Consensus CDS
      CCDS7332.1
      UniProtKB/Swiss-Prot
      P53992
      UniProtKB/TrEMBL
      A0A024QZM6
      Related
      ENSP00000321845.6, ENST00000345254.9
      Conserved Domains (9) summary
      COG5028
      Location:1811090
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:499758
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:9611036
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:422459
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:847943
      Sec23_helical; Sec23/Sec24 helical domain
      pfam04959
      Location:221306
      ARS2; Arsenite-resistance protein 2
      pfam07001
      Location:142248
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:748831
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11105
      Gly-rich_Ago1; Glycine-rich region of argonaut

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      73744164..73772167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540381.3XP_011538683.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_011538683.1

      Conserved Domains (8) summary
      COG5028
      Location:3231113
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:522781
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:9841059
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:445482
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:870966
      Sec23_helical; Sec23/Sec24 helical domain
      pfam07001
      Location:142240
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:771854
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11105
      Gly-rich_Ago1; Glycine-rich region of argonaut
    2. XM_017016968.2XP_016872457.1  protein transport protein Sec24C isoform X3

    3. XM_011540380.3XP_011538682.1  protein transport protein Sec24C isoform X1

      See identical proteins and their annotated locations for XP_011538682.1

      Conserved Domains (8) summary
      COG5028
      Location:3231113
      COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
      cd01479
      Location:522781
      Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam00626
      Location:9841059
      Gelsolin; Gelsolin repeat
      pfam04810
      Location:445482
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:870966
      Sec23_helical; Sec23/Sec24 helical domain
      pfam07001
      Location:142240
      BAT2_N; BAT2 N-terminus
      pfam08033
      Location:771854
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
      pfam12764
      Location:11105
      Gly-rich_Ago1; Glycine-rich region of argonaut
    4. XM_017016967.2XP_016872456.1  protein transport protein Sec24C isoform X2

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