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    TCL1B TCL1 family AKT coactivator B [ Homo sapiens (human) ]

    Gene ID: 9623, updated on 27-Nov-2024

    Summary

    Official Symbol
    TCL1Bprovided by HGNC
    Official Full Name
    TCL1 family AKT coactivator Bprovided by HGNC
    Primary source
    HGNC:HGNC:11649
    See related
    Ensembl:ENSG00000213231 MIM:603769; AllianceGenome:HGNC:11649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TML1; SYN-1
    Summary
    Enables protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 1.5), lymph node (RPKM 1.2) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TCL1B in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95686426..95692628)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89918003..89924209)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96152763..96158965)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370643 Neighboring gene Sharpr-MPRA regulatory region 452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8968 Neighboring gene uncharacterized LOC124903372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96131757-96132404 Neighboring gene T cell leukemia/lymphoma 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96133051-96133697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8972 Neighboring gene uncharacterized LOC124903373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8975 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8976 Neighboring gene TCL1 family AKT coactivator A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    T-cell leukemia/lymphoma protein 1B
    Names
    T cell leukemia/lymphoma 1B
    T-cell lymphoma/leukemia 1B
    TCL1/ MTCP1-like 1
    oncogene TCL-1B
    syncytiotrophoblast-specific protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004918.4NP_004909.1  T-cell leukemia/lymphoma protein 1B

      See identical proteins and their annotated locations for NP_004909.1

      Status: VALIDATED

      Source sequence(s)
      AF137027, BC051000
      Consensus CDS
      CCDS32151.1
      UniProtKB/Swiss-Prot
      A6NEK7, O95988, Q6IAR7, Q9UBQ4
      Related
      ENSP00000343223.6, ENST00000340722.8
      Conserved Domains (1) summary
      pfam01840
      Location:1124
      TCL1_MTCP1; TCL1/MTCP1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      95686426..95692628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      89918003..89924209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199206.2: Suppressed sequence

      Description
      NM_199206.2: This RefSeq was permanently suppressed because it retains intronic sequence.