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    RNF7 ring finger protein 7 [ Homo sapiens (human) ]

    Gene ID: 9616, updated on 17-Jun-2024

    Summary

    Official Symbol
    RNF7provided by HGNC
    Official Full Name
    ring finger protein 7provided by HGNC
    Primary source
    HGNC:HGNC:10070
    See related
    Ensembl:ENSG00000114125 MIM:603863; AllianceGenome:HGNC:10070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAG; ROC2; rbx2; CKBBP1
    Summary
    The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: SAG (Gene ID: 6295) and RNF7 (Gene ID: 9616) share the SAG symbol/alias in common. SAG is a widely used alternative name for ring finger protein 7 (RNF7), which can be confused with the official symbol for SAG (S-antigen visual arrestin, GeneID 6295). [01 Jun 2018]
    Expression
    Ubiquitous expression in testis (RPKM 15.8), adrenal (RPKM 15.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RNF7 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141738298..141747560)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144485514..144494774)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141457140..141466402)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 2 Neighboring gene YWHAQ pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141382574-141383094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:141383095-141383614 Neighboring gene long intergenic non-protein coding RNA 2618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20635 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141456933-141457612 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:141457613-141458291 Neighboring gene TPT1 pseudogene 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:141481495-141481669 Neighboring gene G protein-coupled receptor kinase 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20638 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4237 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4238 Neighboring gene uncharacterized LOC105374134 Neighboring gene VISTA enhancer hs2041

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif Rbx1 I44A and Rbx2 I52A mutants disrupt the level of HIV-1 Vif-mediated APOBEC3G degradation in cells PubMed
    vif CUL5/RBX2/ELOB/ELOC/Vif/CBF-beta complex catalyzes polyubiquitin chain formation on A3G in the presence of ubiquitin E2 UBE2R1 (CDC34) or UBCH5b (UBE2D2) PubMed
    vif UBE2F and RBX2 are required for activation of the polyubiquitin synthesis activity of Vif/CBF-beta/CUL5, leading to HIV-1 Vif-mediated degradation of A3G in cells PubMed
    vif HIV-1 Vif can assemble into the Cul5-containing E3 ligase, the CUL5-RBX2-CBF-beta-ELOB-ELOC complex, in the presence of CBF-beta PubMed
    vif HIV-1 Vif is identified to have a physical interaction with ring finger protein 7 (RNF7; RBX2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NEDD8 ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NEDD8 transferase activity TAS
    Traceable Author Statement
    more info
     
    enables copper ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cullin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in post-translational protein modification TAS
    Traceable Author Statement
    more info
     
    involved_in protein neddylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to redox state TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    RING-box protein 2
    Names
    CKII beta-binding protein 1
    regulator of cullins 2
    sensitive to apoptosis gene protein
    sensitive to apoptosis zinc RING finger protein SAG
    sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
    zinc RING finger protein SAG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201370.2NP_001188299.1  RING-box protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001188299.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC112771, AW150174, BG742338, DB272382
      Consensus CDS
      CCDS56283.1
      UniProtKB/TrEMBL
      B2R4X4
      Related
      ENSP00000419084.1, ENST00000480908.1
      Conserved Domains (1) summary
      cl17238
      Location:4790
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. NM_014245.5NP_055060.1  RING-box protein 2 isoform 1

      See identical proteins and their annotated locations for NP_055060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC112771, AW150174, BG742338
      Consensus CDS
      CCDS3118.1
      UniProtKB/Swiss-Prot
      A8K1H9, A8MTB5, C9JYL3, D3DNF7, D3DNF8, Q9BXN8, Q9UBF6, Q9Y5M7
      UniProtKB/TrEMBL
      B2R4X4
      Related
      ENSP00000273480.3, ENST00000273480.4
      Conserved Domains (1) summary
      cd16466
      Location:47106
      RING-H2_RBX2; RING finger, H2 subclass, found in RING-box protein 2 (RBX2) and similar proteins
    3. NM_183237.3NP_899060.1  RING-box protein 2 isoform 3

      See identical proteins and their annotated locations for NP_899060.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1, which causes a frameshift. The resulting shorter isoform (3) has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC112771, AW150174, BG716023, BG742338
      Consensus CDS
      CCDS43158.1
      UniProtKB/Swiss-Prot
      Q9UBF6
      Related
      ENSP00000376725.3, ENST00000393000.3
      Conserved Domains (1) summary
      cl17238
      Location:2855
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. NR_037702.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a nonsense-mediated mRNA decay candidate and is not thought to be protein-coding.
      Source sequence(s)
      AC112771, AF312226, AW150174, BG742338
    2. NR_037703.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction and contains an alternate exon compared to variant 1, that causes a frameshift. The resulting transcript is a nonsense-mediated mRNA decay candidate and is not thought to be protein-coding.
      Source sequence(s)
      AC112771, AW150174, BG720797, BG742338

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      141738298..141747560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007095770.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      144485514..144494774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486859.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183063.1: Suppressed sequence

      Description
      NM_183063.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.