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    NCOR1 nuclear receptor corepressor 1 [ Homo sapiens (human) ]

    Gene ID: 9611, updated on 15-Apr-2019

    Summary

    Official Symbol
    NCOR1provided by HGNC
    Official Full Name
    nuclear receptor corepressor 1provided by HGNC
    Primary source
    HGNC:HGNC:7672
    See related
    Ensembl:ENSG00000141027 MIM:600849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
    Summary
    This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.9), colon (RPKM 10.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See NCOR1 in Genome Data Viewer
    Location:
    17p12-p11.2
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (16030094..16216475, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15933408..16118874, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene adenosine A2b receptor Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 11 Neighboring gene ribosomal protein L22 pseudogene 21 Neighboring gene RNA, U6 small nuclear 314, pseudogene Neighboring gene RNA, U6 small nuclear 862, pseudogene Neighboring gene small nucleolar RNA, C/D box 163 Neighboring gene RNA, 7SL, cytoplasmic 442, pseudogene Neighboring gene phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene microRNA 1288 Neighboring gene centromere protein V

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with nuclear receptor corepressor 1 (NCOR1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Activation of HOX genes during differentiation, organism-specific biosystem (from REACTOME)
      Activation of HOX genes during differentiation, organism-specific biosystemHox genes encode proteins that contain the DNA-binding homeobox motif and control early patterning of segments in the embryo as well as later events in development (reviewed in Rezsohazy et al. 2015)...
    • Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystem (from REACTOME)
      Activation of anterior HOX genes in hindbrain development during early embryogenesis, organism-specific biosystemIn mammals, anterior Hox genes may be defined as paralog groups 1 to 4 (Natale et al. 2011), which are involved in development of the hindbrain through sequential expression in the rhombomeres, trans...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
      BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem (from REACTOME)
      Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystemTranscriptional activity of SMAD2/3:SMAD4 heterotrimer can be inhibited by formation of a complex with SKI or SKIL (SNO), where SKI or SKIL recruit NCOR and possibly other transcriptional repressors ...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB4 signaling events, organism-specific biosystem
      ErbB4 signaling events
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • HDACs deacetylate histones, organism-specific biosystem (from REACTOME)
      HDACs deacetylate histones, organism-specific biosystemLysine deacetylases (KDACs), historically referred to as histone deacetylases (HDACs), are divided into the Rpd3/Hda1 metal-dependent 'classical HDAC family' (de Ruijter et al. 2003, Verdin et al. 2...
    • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Mitochondrial biogenesis, organism-specific biosystemMitochondrial biogenesis and remodeling occur in response to exercise and redox state (reviewed in Scarpulla et al. 2012, Handy and Loscalzo 2012, Piantadosi and Suliman 2012, Scarpulla 2011, Wenz et...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • NR1D1 (REV-ERBA) represses gene expression, organism-specific biosystem (from REACTOME)
      NR1D1 (REV-ERBA) represses gene expression, organism-specific biosystemREV-ERBA binds DNA elements very similar to those bound by the transcription activator RORA. RORAREV-ERBA bound to DNA and heme recruits the corepressors NCoR and HDAC3 to repress transcription. Thu...
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch pathway is an evolutionally conserved signaling pathway which plays an important role in diverse developmental and physiological processes. These include cell-fate determination, tissue pat...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
    • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
      PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystem (from WikiPathways)
      Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystemProtein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and not...
    • RORA activates gene expression, organism-specific biosystem (from REACTOME)
      RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
    • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
      Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Transcriptional activation of mitochondrial biogenesis, organism-specific biosystem (from REACTOME)
      Transcriptional activation of mitochondrial biogenesis, organism-specific biosystemPhosphorylated PPARGC1A (PGC-1alpha) does not bind DNA directly but instead interacts with other transcription factors, notably NRF1 and NRF2 (via HCF1). NRF1 and NRF2 together with PPARGC1A activate...
    • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
      Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemIn the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcrip...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Transcriptional regulation of white adipocyte differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional regulation of white adipocyte differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1047, MGC104216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nuclear hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thyroid hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription regulatory region DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    circadian rhythm TAS
    Traceable Author Statement
    more info
     
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of fatty acid transport IC
    Inferred by Curator
    more info
    PubMed 
    regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Sin3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with Sin3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcriptional repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear receptor corepressor 1
    Names
    protein phosphatase 1, regulatory subunit 109
    thyroid hormone- and retinoic acid receptor-associated corepressor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047111.1 RefSeqGene

      Range
      6187..191653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190438.1NP_001177367.1  nuclear receptor corepressor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF303586, BC056862
      Consensus CDS
      CCDS54094.1
      UniProtKB/Swiss-Prot
      O75376
      UniProtKB/TrEMBL
      Q6PGR4
      Related
      ENSP00000379189.1, ENST00000395848.5
      Conserved Domains (4) summary
      pfam05887
      Location:596677
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      smart00717
      Location:518563
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:518561
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:41128
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    2. NM_001190440.1NP_001177369.1  nuclear receptor corepressor 1 isoform 3

      See identical proteins and their annotated locations for NP_001177369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AB028970, AC002553, AW015698, BC056862
      Consensus CDS
      CCDS54095.1
      UniProtKB/Swiss-Prot
      O75376
      UniProtKB/TrEMBL
      Q6PGR4
      Related
      ENSP00000379192.1, ENST00000395851.5
      Conserved Domains (4) summary
      smart00717
      Location:627672
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:678760
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    3. NM_006311.4NP_006302.2  nuclear receptor corepressor 1 isoform 1

      See identical proteins and their annotated locations for NP_006302.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC002553, AF044209, AW015698, BJ995810
      Consensus CDS
      CCDS11175.1
      UniProtKB/Swiss-Prot
      O75376
      UniProtKB/TrEMBL
      A0A024RD47
      Related
      ENSP00000268712.2, ENST00000268712.8
      Conserved Domains (3) summary
      smart00717
      Location:627672
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      16030094..16216475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524086.3XP_011522388.1  nuclear receptor corepressor 1 isoform X16

      See identical proteins and their annotated locations for XP_011522388.1

      UniProtKB/Swiss-Prot
      O75376
      Conserved Domains (4) summary
      smart00717
      Location:627672
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:678760
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    2. XM_017025415.2XP_016880904.1  nuclear receptor corepressor 1 isoform X9

    3. XM_017025418.2XP_016880907.1  nuclear receptor corepressor 1 isoform X14

    4. XM_011524084.3XP_011522386.1  nuclear receptor corepressor 1 isoform X3

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    5. XM_006721603.4XP_006721666.1  nuclear receptor corepressor 1 isoform X6

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    6. XM_017025406.2XP_016880895.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    7. XM_011524083.3XP_011522385.1  nuclear receptor corepressor 1 isoform X1

      See identical proteins and their annotated locations for XP_011522385.1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    8. XM_017025411.2XP_016880900.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    9. XM_017025397.2XP_016880886.1  nuclear receptor corepressor 1 isoform X1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    10. XM_017025401.2XP_016880890.1  nuclear receptor corepressor 1 isoform X2

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    11. XM_017025400.2XP_016880889.1  nuclear receptor corepressor 1 isoform X2

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    12. XM_017025396.2XP_016880885.1  nuclear receptor corepressor 1 isoform X1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    13. XM_006721601.4XP_006721664.1  nuclear receptor corepressor 1 isoform X1

      See identical proteins and their annotated locations for XP_006721664.1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    14. XM_017025416.2XP_016880905.1  nuclear receptor corepressor 1 isoform X10

      Conserved Domains (4) summary
      smart00717
      Location:627672
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:678760
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    15. XM_017025409.2XP_016880898.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    16. XM_006721602.4XP_006721665.1  nuclear receptor corepressor 1 isoform X2

      See identical proteins and their annotated locations for XP_006721665.1

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    17. XM_017025403.2XP_016880892.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    18. XM_006721604.4XP_006721667.1  nuclear receptor corepressor 1 isoform X10

      Conserved Domains (4) summary
      smart00717
      Location:627672
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:678760
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    19. XM_005256872.5XP_005256929.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    20. XM_005256871.5XP_005256928.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    21. XM_005256866.5XP_005256923.1  nuclear receptor corepressor 1 isoform X1

      See identical proteins and their annotated locations for XP_005256923.1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    22. XM_005256868.5XP_005256925.1  nuclear receptor corepressor 1 isoform X2

      See identical proteins and their annotated locations for XP_005256925.1

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    23. XM_017025420.2XP_016880909.1  nuclear receptor corepressor 1 isoform X17

    24. XM_017025417.2XP_016880906.1  nuclear receptor corepressor 1 isoform X11

    25. XM_005256873.5XP_005256930.1  nuclear receptor corepressor 1 isoform X7

      Conserved Domains (3) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    26. XM_017025419.2XP_016880908.1  nuclear receptor corepressor 1 isoform X15

    27. XM_005256874.5XP_005256931.1  nuclear receptor corepressor 1 isoform X8

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    28. XM_005256875.4XP_005256932.1  nuclear receptor corepressor 1 isoform X12

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    29. XM_011524085.3XP_011522387.1  nuclear receptor corepressor 1 isoform X13

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    30. XM_017025410.2XP_016880899.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    31. XM_017025404.2XP_016880893.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    32. XM_024451041.1XP_024306809.1  nuclear receptor corepressor 1 isoform X2

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    33. XM_017025398.2XP_016880887.1  nuclear receptor corepressor 1 isoform X1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    34. XM_024451043.1XP_024306811.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    35. XM_017025407.2XP_016880896.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    36. XM_017025414.2XP_016880903.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    37. XM_017025412.2XP_016880901.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    38. XM_017025405.2XP_016880894.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    39. XM_017025399.2XP_016880888.1  nuclear receptor corepressor 1 isoform X1

      Conserved Domains (4) summary
      smart00717
      Location:637682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688770
      SDA1; SDA1
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    40. XM_017025408.2XP_016880897.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    41. XM_017025413.2XP_016880902.1  nuclear receptor corepressor 1 isoform X5

      Conserved Domains (3) summary
      cd00167
      Location:627670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    42. XM_024451042.1XP_024306810.1  nuclear receptor corepressor 1 isoform X4

      Conserved Domains (3) summary
      cd00167
      Location:628671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    43. XM_017025402.2XP_016880891.1  nuclear receptor corepressor 1 isoform X2

      Conserved Domains (3) summary
      cd00167
      Location:636679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
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