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    BAG2 BAG cochaperone 2 [ Homo sapiens (human) ]

    Gene ID: 9532, updated on 9-Jun-2024

    Summary

    Official Symbol
    BAG2provided by HGNC
    Official Full Name
    BAG cochaperone 2provided by HGNC
    Primary source
    HGNC:HGNC:938
    See related
    Ensembl:ENSG00000112208 MIM:603882; AllianceGenome:HGNC:938
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAG-2; dJ417I1.2
    Summary
    BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in endometrium (RPKM 20.1), urinary bladder (RPKM 13.7) and 21 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See BAG2 in Genome Data Viewer
    Location:
    6p12.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57172326..57189833)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (57011351..57028858)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (57037124..57054631)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene zinc finger protein 451 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17304 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:57211753-57212253 Neighboring gene microRNA 548u

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0576, MGC149462

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with dendritic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    colocalizes_with microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein folding chaperone complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 2
    Names
    BCL2 associated athanogene 2
    bcl-2-associated athanogene 2
    dJ417I1.2 (BAG-family molecular chaperone regulator 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004282.4NP_004273.1  BAG family molecular chaperone regulator 2

      See identical proteins and their annotated locations for NP_004273.1

      Status: REVIEWED

      Source sequence(s)
      AL031321, AL050287, AL136311, CA442969, DA874388
      Consensus CDS
      CCDS4961.1
      UniProtKB/Swiss-Prot
      B4DXE2, O95816, Q08AS9, Q6FID0
      UniProtKB/TrEMBL
      B3KM36, B3KN59
      Related
      ENSP00000359727.4, ENST00000370693.5
      Conserved Domains (1) summary
      smart00264
      Location:109189
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      57172326..57189833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249490.5XP_005249547.1  BAG family molecular chaperone regulator 2 isoform X1

      See identical proteins and their annotated locations for XP_005249547.1

      UniProtKB/TrEMBL
      B3KM36, B3KN59
      Conserved Domains (1) summary
      smart00264
      Location:76156
      BAG; BAG domains, present in regulator of Hsp70 proteins
    2. XM_011514999.4XP_011513301.1  BAG family molecular chaperone regulator 2 isoform X1

      See identical proteins and their annotated locations for XP_011513301.1

      UniProtKB/TrEMBL
      B3KM36, B3KN59
      Conserved Domains (1) summary
      smart00264
      Location:76156
      BAG; BAG domains, present in regulator of Hsp70 proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      57011351..57028858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356854.1XP_054212829.1  BAG family molecular chaperone regulator 2 isoform X1

      UniProtKB/TrEMBL
      B3KM36, B3KN59
    2. XM_054356855.1XP_054212830.1  BAG family molecular chaperone regulator 2 isoform X1

      UniProtKB/TrEMBL
      B3KM36, B3KN59