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    SCARB1 scavenger receptor class B member 1 [ Homo sapiens (human) ]

    Gene ID: 949, updated on 17-Jun-2024

    Summary

    Official Symbol
    SCARB1provided by HGNC
    Official Full Name
    scavenger receptor class B member 1provided by HGNC
    Primary source
    HGNC:HGNC:1664
    See related
    Ensembl:ENSG00000073060 MIM:601040; AllianceGenome:HGNC:1664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLCQ6; HDLQTL6
    Summary
    The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2. [provided by RefSeq, Oct 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Biased expression in adrenal (RPKM 333.6), placenta (RPKM 91.6) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SCARB1 in Genome Data Viewer
    Location:
    12q24.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124776856..124863864, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124782134..124869001, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (125261402..125348410, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125106212-125107104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125107105-125107998 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:125117605-125118804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125120143-125120783 Neighboring gene Sharpr-MPRA regulatory region 4504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125130641-125131250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136287-125136800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136801-125137314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125158286-125158903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125160065-125160662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125161261-125161858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169899-125170441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169354-125169898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125172481-125173202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125179365-125179866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125197387-125198032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125198033-125198677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125215664-125216268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125216269-125216872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125218412-125219186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125219187-125219961 Neighboring gene uncharacterized LOC124903045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125234102-125234622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125234623-125235143 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125239799-125240701 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125242645-125243146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125243147-125243646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125245231-125245731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7300 Neighboring gene Sharpr-MPRA regulatory region 2215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7303 Neighboring gene MPRA-validated peak2030 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125268792-125269560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125270855-125271355 Neighboring gene uncharacterized LOC124903046 Neighboring gene MPRA-validated peak2031 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125282050-125282560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125282561-125283071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125301275-125301774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125309151-125309872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125309873-125310594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125323854-125324380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125324381-125324905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7305 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125346238-125346764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5067 Neighboring gene uncharacterized LOC105370050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7306 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25236 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:125351043-125352242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125369125-125369812 Neighboring gene CRISPRi-validated cis-regulatory element chr12.4732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7308 Neighboring gene RNA, U6 small nuclear 927, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    High density lipoprotein cholesterol level quantitative trait locus 6
    MedGen: C1853096 OMIM: 610762 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
    EBI GWAS Catalog
    Genome-wide association study identifies common variants associated with circulating vitamin E levels.
    EBI GWAS Catalog
    Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SCARB1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables apolipoprotein A-I binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables high-density lipoprotein particle binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables high-density lipoprotein particle receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables high-density lipoprotein particle receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipopolysaccharide immune receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables low-density lipoprotein particle binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables low-density lipoprotein particle binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylserine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scavenger receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scavenger receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adhesion of symbiont to host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in carotenoid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol efflux IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol import IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in detection of lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in high-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in high-density lipoprotein particle remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intestinal lipid absorption IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in low-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phospholipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in plasma lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cholesterol storage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of triglyceride biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in recognition of apoptotic cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in recognition of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of phagocytosis IC
    Inferred by Curator
    more info
    PubMed 
    involved_in regulation of phosphatidylcholine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in reverse cholesterol transport IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vitamin transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in caveola IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane HDA PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    scavenger receptor class B member 1
    Names
    CD36 and LIMPII analogous 1
    CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
    scavenger receptor class B type III

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028199.1 RefSeqGene

      Range
      5110..92118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001082959.2NP_001076428.1  scavenger receptor class B member 1 isoform 2

      See identical proteins and their annotated locations for NP_001076428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC073593, AC126309
      Consensus CDS
      CCDS45008.1
      UniProtKB/TrEMBL
      A0A7P0T9I2
      Related
      ENSP00000343795.4, ENST00000339570.9
      Conserved Domains (1) summary
      pfam01130
      Location:16446
      CD36; CD36 family
    2. NM_001367981.1NP_001354910.1  scavenger receptor class B member 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC073593, AC126309, BC022087
      Consensus CDS
      CCDS91769.1
      UniProtKB/Swiss-Prot
      F8W8N0, Q14016, Q52LZ5, Q6KFX4, Q8WTV0
      UniProtKB/TrEMBL
      A0A0S2Z3N2
      Related
      ENSP00000414979.2, ENST00000415380.6
    3. NM_001367982.1NP_001354911.1  scavenger receptor class B member 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309, AK124112
      UniProtKB/TrEMBL
      B3KW46, B4DZ71
      Related
      ENSP00000444851.1, ENST00000544327.1
    4. NM_001367983.1NP_001354912.1  scavenger receptor class B member 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      UniProtKB/TrEMBL
      A0A7P0T9I2
    5. NM_001367984.1NP_001354913.1  scavenger receptor class B member 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      UniProtKB/TrEMBL
      A0A7P0T9I2
    6. NM_001367985.1NP_001354914.1  scavenger receptor class B member 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      UniProtKB/TrEMBL
      A0A7P0T9I2
    7. NM_001367986.1NP_001354915.1  scavenger receptor class B member 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309, BC143319
      Consensus CDS
      CCDS91770.1
      UniProtKB/TrEMBL
      A0A7P0T913, B7ZKQ9
      Related
      ENSP00000442862.1, ENST00000546215.5
    8. NM_001367987.1NP_001354916.1  scavenger receptor class B member 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      Consensus CDS
      CCDS91771.1
      UniProtKB/TrEMBL
      A0A7P0T9I2, A0A7P0Z4E3
      Related
      ENSP00000505757.1, ENST00000680556.1
    9. NM_001367988.1NP_001354917.1  scavenger receptor class B member 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    10. NM_001367989.1NP_001354918.1  scavenger receptor class B member 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC073593, AC126309
      Consensus CDS
      CCDS9259.1
      UniProtKB/TrEMBL
      A0A7P0T9I2
      Conserved Domains (1) summary
      pfam01130
      Location:16446
      CD36; CD36 family
    11. NM_005505.5NP_005496.4  scavenger receptor class B member 1 isoform 1

      See identical proteins and their annotated locations for NP_005496.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 13 both encode the same isoform (1).
      Source sequence(s)
      AC073593, BC080647, BG770204, CA428516
      Consensus CDS
      CCDS9259.1
      UniProtKB/TrEMBL
      A0A7P0T9I2
      Related
      ENSP00000261693.6, ENST00000261693.11
      Conserved Domains (1) summary
      pfam01130
      Location:16446
      CD36; CD36 family

    RNA

    1. NR_160416.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    2. NR_160417.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    3. NR_160418.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      Related
      ENST00000679605.1
    4. NR_160419.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    5. NR_160420.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    6. NR_160421.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    7. NR_160422.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    8. NR_160423.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
    9. NR_160424.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073593, AC126309
      Related
      ENST00000680926.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      124776856..124863864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      124782134..124869001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)