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    Fkbp6 FK506 binding protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 94244, updated on 31-Jan-2019

    Summary

    Official Symbol
    Fkbp6provided by MGI
    Official Full Name
    FK506 binding protein 6provided by MGI
    Primary source
    MGI:MGI:2137612
    See related
    Ensembl:ENSMUSG00000040013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    36kDa; FKBP-6; FKBP-36; AU017274; D5Ertd724e; 1700008G22Rik
    Summary
    This gene is a member of the FK506-binding protein (Fkbp) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to Hsp90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
    Expression
    Restricted expression toward testis adult (RPKM 22.2) See more
    Orthologs

    Genomic context

    See Fkbp6 in Genome Data Viewer
    Location:
    5 G2; 5 75.11 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135291704..135351810, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (135767574..135825861, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 1B Neighboring gene frizzled class receptor 9 Neighboring gene tripartite motif-containing 50 Neighboring gene NOL1/NOP2/Sun domain family, member 5 Neighboring gene nuclear pore membrane protein 121

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA methylation involved in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    gene silencing by RNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    piRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inactive peptidyl-prolyl cis-trans isomerase FKBP6
    Names
    36 kDa FK506-binding protein
    36 kDa FKBP
    PPIase FKBP6
    immunophilin FKBP36
    inactive PPIase FKBP6
    peptidyl-prolyl cis-trans isomerase FKBP6
    rotamase
    NP_001264820.1
    NP_001264821.1
    NP_001264822.1
    NP_291049.1
    XP_011239215.1
    XP_011239217.1
    XP_017176678.1
    XP_017176679.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277891.1NP_001264820.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1

      See identical proteins and their annotated locations for NP_001264820.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC074359, AF367709
      Consensus CDS
      CCDS19738.1
      UniProtKB/Swiss-Prot
      Q91XW8
      Related
      ENSMUSP00000144471.1, ENSMUST00000201534.1
      Conserved Domains (3) summary
      sd00006
      Location:218248
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:220284
      TPR_11; TPR repeat
    2. NM_001277892.1NP_001264821.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 2

      See identical proteins and their annotated locations for NP_001264821.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus but is of the same size as isoform 1.
      Source sequence(s)
      AC074359, AY029192
      Consensus CDS
      CCDS80425.1
      UniProtKB/Swiss-Prot
      Q91XW8
      Related
      ENSMUSP00000144381.1, ENSMUST00000201784.3
      Conserved Domains (3) summary
      sd00006
      Location:218248
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:220284
      TPR_11; TPR repeat
    3. NM_001277893.1NP_001264822.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 3

      See identical proteins and their annotated locations for NP_001264822.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC074359
      Consensus CDS
      CCDS80426.1
      UniProtKB/Swiss-Prot
      Q91XW8
      Related
      ENSMUSP00000144460.1, ENSMUST00000201791.3
      Conserved Domains (3) summary
      sd00006
      Location:181207
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:180244
      TPR_11; TPR repeat
    4. NM_033571.3NP_291049.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1

      See identical proteins and their annotated locations for NP_291049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC074359
      Consensus CDS
      CCDS19738.1
      UniProtKB/Swiss-Prot
      Q91XW8
      Related
      ENSMUSP00000043193.7, ENSMUST00000044972.10
      Conserved Domains (3) summary
      sd00006
      Location:218248
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:220284
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      135291704..135351810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321189.1XP_017176678.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X2

      Conserved Domains (3) summary
      sd00006
      Location:254284
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:86176
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:256320
      TPR_11; TPR repeat
    2. XM_017321190.1XP_017176679.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X1

      UniProtKB/Swiss-Prot
      Q91XW8
      Conserved Domains (3) summary
      sd00006
      Location:218248
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:220284
      TPR_11; TPR repeat
    3. XM_011240915.1XP_011239217.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X3

      See identical proteins and their annotated locations for XP_011239217.1

      UniProtKB/Swiss-Prot
      Q91XW8
      Conserved Domains (3) summary
      sd00006
      Location:181207
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:180244
      TPR_11; TPR repeat
    4. XM_011240913.1XP_011239215.1  inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform X1

      See identical proteins and their annotated locations for XP_011239215.1

      UniProtKB/Swiss-Prot
      Q91XW8
      Conserved Domains (3) summary
      sd00006
      Location:218248
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50140
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam13414
      Location:220284
      TPR_11; TPR repeat
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