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    Cnnm2 cyclin M2 [ Mus musculus (house mouse) ]

    Gene ID: 94219, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cnnm2provided by MGI
    Official Full Name
    cyclin M2provided by MGI
    Primary source
    MGI:MGI:2151054
    See related
    Ensembl:ENSMUSG00000064105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clp2; Acdp2; AU015877; AW048635
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.0), adrenal adult (RPKM 6.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cnnm2 in Genome Data Viewer
    Location:
    19 C3; 19 38.97 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (46761564..46878580)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (46836099..46953070)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene arsenic (+3 oxidation state) methyltransferase Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene DBF4 homolog pseudogene Neighboring gene lysophosphatidic acid receptor 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metal transporter CNNM2
    Names
    ancient conserved domain protein 2
    ancient conserved domain-containing protein 2
    cyclin-like protein 2
    mACDP2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102471.1NP_001095941.1  metal transporter CNNM2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF216961, AK159616, BC052513
      Consensus CDS
      CCDS50460.1
      UniProtKB/Swiss-Prot
      Q3TWN3
      Related
      ENSMUSP00000076850.4, ENSMUST00000077666.4
      Conserved Domains (2) summary
      cd04590
      Location:470575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257431
      DUF21; Domain of unknown function DUF21
    2. NM_033569.3NP_291047.2  metal transporter CNNM2 isoform a

      See identical proteins and their annotated locations for NP_291047.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF216961, AK159616, BC052513
      Consensus CDS
      CCDS50459.1
      UniProtKB/Swiss-Prot
      Q3TWN3
      Related
      ENSMUSP00000096972.4, ENSMUST00000099373.10
      Conserved Domains (2) summary
      cd04590
      Location:470575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257431
      DUF21; Domain of unknown function DUF21

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      46761564..46878580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527489.3XP_006527552.1  metal transporter CNNM2 isoform X1

      Conserved Domains (2) summary
      cd04590
      Location:470575
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
      pfam01595
      Location:257431
      DUF21; Domain of unknown function DUF21
    2. XM_006527490.3XP_006527553.1  metal transporter CNNM2 isoform X2

      Conserved Domains (2) summary
      pfam01595
      Location:257431
      DUF21; Domain of unknown function DUF21
      cl15354
      Location:470540
      CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
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