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    Ddx50 DExD box helicase 50 [ Mus musculus (house mouse) ]

    Gene ID: 94213, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ddx50provided by MGI
    Official Full Name
    DExD box helicase 50provided by MGI
    Primary source
    MGI:MGI:2182303
    See related
    Ensembl:ENSMUSG00000020076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GU2; RH-II; 4933429B04Rik; 8430408E17Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 26.0), bladder adult (RPKM 19.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Ddx50 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62451571..62487260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62615792..62658764, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62078771..62113946, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene kinesin family binding protein Neighboring gene DExD box helicase 21 Neighboring gene predicted gene, 51417 Neighboring gene storkhead box 1 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX50
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
    DEAD box protein 50
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50
    RH-II/Gubeta
    gu-beta
    nucleolar protein GU2
    NP_001345748.1
    NP_001345749.1
    NP_444413.1
    XP_006514408.1
    XP_011241910.1
    XP_030101267.1
    XP_030101268.1
    XP_030101269.1
    XP_030101270.1
    XP_036012018.1
    XP_036012019.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358819.1NP_001345748.1  ATP-dependent RNA helicase DDX50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121961, AK041281, AK162423
      Conserved Domains (3) summary
      COG0513
      Location:65543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    2. NM_001358820.1NP_001345749.1  ATP-dependent RNA helicase DDX50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030239, AK041281, CF898436
      Related
      ENSMUST00000218372.2
      Conserved Domains (3) summary
      COG0513
      Location:65543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    3. NM_053183.3NP_444413.1  ATP-dependent RNA helicase DDX50 isoform 1

      See identical proteins and their annotated locations for NP_444413.1

      Status: VALIDATED

      Source sequence(s)
      AC121961, AK041281, AK162423
      Consensus CDS
      CCDS23892.1
      UniProtKB/Swiss-Prot
      Q99MJ9
      Related
      ENSMUSP00000020270.5, ENSMUST00000020270.6
      Conserved Domains (4) summary
      COG0513
      Location:130608
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:369486
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:136339
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      cd12936
      Location:565656
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62451571..62487260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514345.5XP_006514408.1  ATP-dependent RNA helicase DDX50 isoform X1

      Conserved Domains (3) summary
      COG0513
      Location:130554
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:511602
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:145346
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    2. XM_030245409.2XP_030101269.1  ATP-dependent RNA helicase DDX50 isoform X3

      Conserved Domains (3) summary
      COG0513
      Location:65489
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:446537
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    3. XM_011243608.4XP_011241910.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    4. XM_030245410.2XP_030101270.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    5. XM_036156125.1XP_036012018.1  ATP-dependent RNA helicase DDX50 isoform X4

      Conserved Domains (2) summary
      COG0513
      Location:1317
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:274365
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
    6. XM_036156126.1XP_036012019.1  ATP-dependent RNA helicase DDX50 isoform X5

      Conserved Domains (3) summary
      COG0513
      Location:1263
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:220311
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cl28899
      Location:155
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    7. XM_030245408.2XP_030101268.1  ATP-dependent RNA helicase DDX50 isoform X2

      Conserved Domains (3) summary
      COG0513
      Location:65543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
    8. XM_030245407.2XP_030101267.1  ATP-dependent RNA helicase DDX50 isoform X2

      Conserved Domains (3) summary
      COG0513
      Location:65543
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd12936
      Location:500591
      GUCT_RHII_Gualpha_beta; RNA-binding GUCT domain found in vertebrate RNA helicase II/Gualpha (RH-II/Gualpha), RNA helicase II/Gubeta (RH-II/Gubeta) and similar proteins
      cd17944
      Location:80281
      DEADc_DDX21_DDX50; DEAD-box helicase domain of DEAD box proteins 21 and 50
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