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    Nans N-acetylneuraminic acid synthase (sialic acid synthase) [ Mus musculus (house mouse) ]

    Gene ID: 94181, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nansprovided by MGI
    Official Full Name
    N-acetylneuraminic acid synthase (sialic acid synthase)provided by MGI
    Primary source
    MGI:MGI:2149820
    See related
    Ensembl:ENSMUSG00000028334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sas; BB056474; 4632418E04Rik
    Expression
    Broad expression in colon adult (RPKM 145.1), genital fat pad adult (RPKM 46.1) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Nans in Genome Data Viewer
    Location:
    4; 4 B1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46489255..46503440)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46489329..46503438)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (46502201..46516310)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene hemogen Neighboring gene acidic (leucine-rich) nuclear phosphoprotein 32 family, member B Neighboring gene predicted gene, 22247 Neighboring gene tripartite motif-containing 14 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acylneuraminate-9-phosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables N-acylneuraminate-9-phosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in carbohydrate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    sialic acid synthase
    Names
    N-acetylneuraminate-9-phosphate synthase
    N-acetylneuraminic acid 9-phosphate synthetase
    N-acetylneuraminic acid phosphate synthase
    NP_444409.1
    XP_036020474.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053179.3NP_444409.1  sialic acid synthase

      See identical proteins and their annotated locations for NP_444409.1

      Status: PROVISIONAL

      Source sequence(s)
      AK076290
      Consensus CDS
      CCDS18152.1
      UniProtKB/Swiss-Prot
      Q99J77
      Related
      ENSMUSP00000030018.5, ENSMUST00000030018.5
      Conserved Domains (2) summary
      cd11615
      Location:292348
      SAF_NeuB_like; C-terminal SAF domain of sialic acid synthetase
      pfam03102
      Location:40278
      NeuB; NeuB family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      46489255..46503440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164581.1XP_036020474.1  sialic acid synthase isoform X1

      Conserved Domains (1) summary
      pfam03102
      Location:40278
      NeuB; NeuB family
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