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    CD80 CD80 molecule [ Homo sapiens (human) ]

    Gene ID: 941, updated on 13-Mar-2020

    Summary

    Official Symbol
    CD80provided by HGNC
    Official Full Name
    CD80 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1700
    See related
    Ensembl:ENSG00000121594 MIM:112203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1
    Summary
    The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in appendix (RPKM 2.0), lymph node (RPKM 1.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See CD80 in Genome Data Viewer
    Location:
    3q13.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119524293..119559614, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119243140..119278481, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane protein 39A Neighboring gene protein O-glucosyltransferase 1 Neighboring gene translocase of inner mitochondrial membrane domain containing 1 Neighboring gene cysteine and glycine rich protein 2 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 12076 Neighboring gene uncharacterized LOC107986118 Neighboring gene ADP-ribosylarginine hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.
    NHGRI GWA Catalog
    Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
    NHGRI GWA Catalog
    Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
    NHGRI GWA Catalog
    Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
    NHGRI GWA Catalog
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
    env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed
    env The presence of HIV-1 gp120 inhibits the oral mucosal pathogen Porphyromonas gingivalis-induced CD80, CD83, and CD86 upregulation PubMed
    env Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells PubMed
    env The binding of HIV-1 gp120 to CD4 molecules on T cells interrupts the sequential cascade of intercellular interactions involving antigen/MHC class II-TCR/CD4, CD40L-CD40, and B71-CD28 PubMed
    Nef nef HIV-1 Nef induces upregulation of CD80, CD83, and CD86 protein expression in a concentration dependent fashion in monocyte derived dendritic cells PubMed
    nef HIV-1 Nef co-localizes with MHC class I (MHCI), CD80, and CD86 in intracellular compartments by staining assays, and binds to both human CD80 and CD86 using yeast two-hybrid assays PubMed
    nef HIV-1 Nef downregulates the co-stimulatory molecule CD80 from the cell surface in the human monocytic U937 cell line as well as in mouse macrophages and dendritic cells PubMed
    nef HIV-1 Nef-induced B-cell differentiation response is suppressed by monoclonal antibodies to cell surface molecule B7, indicating an interaction between Nef and B7 PubMed
    nef HIV-1 Nef binds to the cytosolic tails of CD80 and CD86 to mediate their internalization PubMed
    nef Activation and translocation of Src kinase is critical for Nef-mediated CD80 and CD86 internalization PubMed
    nef HIV-1 Nef relocates cell-surface MHC-I, CD80, and CD86 to intracellular compartments and the Nef-mediated internalization is dependent on mediators of actin polymerization PubMed
    Pr55(Gag) gag Expression of CD80, CD83, CD86, and HLA-DR molecules are significantly downregulated in mature dendritic cells after transduction with ubiquitinated Gag compared to unubiquitinated Gag constructs PubMed
    gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
    gag HIV-1 Gag virus-like particle-induced monocyte activation is shown by upregulation of molecules involved in antigen presentation (MHC II, CD80, CD86) and cell adhesion (CD54) PubMed
    Tat tat HIV-1 Tat upregulates the expression of MHC and co-stimulatory molecules CD40, CD80, CD83 and CD86 in monocyte-derived dendritic cells, thereby driving T cell-mediated immune responses PubMed
    Vpr vpr HIV-1 Vpr downregulates the expression of several immunologically important molecules including CD40, CD80, CD83, and CD86 co-stimulatory molecules on monocyte-derived macrophage (MDM) and monocyte-derived dendritic cells (MDDC) PubMed
    vpr HIV-1 Vpr inhibits the expression of co-stimulatory molecules including CD80, CD83, and CD86 at the transcriptional level without altering normal cellular transcription during dendritic cell maturation PubMed
    capsid gag The immobilization of HIV-1 p24 antigen on the micelles upregulates the expression of cell surface markers CD80 and CD86 in human dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    coreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of T-helper 1 cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of interleukin-2 biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface HDA PubMed 
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex involved in cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-lymphocyte activation antigen CD80
    Names
    B-lymphocyte activation antigen B7
    CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
    CTLA-4 counter-receptor B7.1
    activation B7-1 antigen
    costimulatory factor CD80
    costimulatory molecule variant IgV-CD80

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005191.4NP_005182.1  T-lymphocyte activation antigen CD80 precursor

      See identical proteins and their annotated locations for NP_005182.1

      Status: REVIEWED

      Source sequence(s)
      AC073352, BC042665, BP225173
      Consensus CDS
      CCDS2989.1
      UniProtKB/Swiss-Prot
      P33681
      UniProtKB/TrEMBL
      A0N0P2
      Related
      ENSP00000264246.3, ENST00000264246.8
      Conserved Domains (2) summary
      cd16083
      Location:142232
      IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80
      cd16086
      Location:35139
      IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      119524293..119559614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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