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    Trim33 tripartite motif-containing 33 [ Mus musculus (house mouse) ]

    Gene ID: 94093, updated on 23-Jun-2021

    Summary

    Official Symbol
    Trim33provided by MGI
    Official Full Name
    tripartite motif-containing 33provided by MGI
    Primary source
    MGI:MGI:2137357
    See related
    Ensembl:ENSMUSG00000033014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ect; Ecto; Tif1; Tif1g; ectode; AI413936; 8030451N04Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 7.3), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Trim33 in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103186609..103266086)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103279293..103358770)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (103083216..103162691)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene BCAS2 pre-mRNA processing factor Neighboring gene predicted gene, 40113 Neighboring gene predicted gene, 25009 Neighboring gene predicted gene, 25869

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA1113, DKFZp586K1123

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM33
    Names
    RING-type E3 ubiquitin transferase TRIM33
    TIF1-gamma
    ectodermin homolog
    transcription intermediary factor 1-gamma
    tripartite motif-containing protein 33
    NP_001073299.1
    NP_444400.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079830.2NP_001073299.1  E3 ubiquitin-protein ligase TRIM33 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC164089, AK129293
      Consensus CDS
      CCDS38574.1
      UniProtKB/Swiss-Prot
      Q99PP7
      UniProtKB/TrEMBL
      E9QME5
      Related
      ENSMUSP00000102473.2, ENSMUST00000106860.6
      Conserved Domains (6) summary
      cd05502
      Location:9711079
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:333459
      BBC; B-Box C-terminal domain
      smart00336
      Location:226262
      BBOX; B-Box-type zinc finger
      cd00021
      Location:288326
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:138202
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:902947
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)
    2. NM_053170.3NP_444400.2  E3 ubiquitin-protein ligase TRIM33 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC164089, AY458590
      Consensus CDS
      CCDS38573.1
      UniProtKB/Swiss-Prot
      Q99PP7
      UniProtKB/TrEMBL
      E9QP19
      Related
      ENSMUSP00000029444.7, ENSMUST00000029444.13
      Conserved Domains (6) summary
      cd05502
      Location:9711096
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:333459
      BBC; B-Box C-terminal domain
      smart00336
      Location:226262
      BBOX; B-Box-type zinc finger
      cd00021
      Location:288326
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd00162
      Location:138202
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd15624
      Location:902947
      PHD_TIF1gamma; PHD finger found in transcriptional intermediary factor 1 gamma (TIF1gamma)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      103186609..103266086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003954429.2 RNA Sequence

    2. XR_375607.5 RNA Sequence

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