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    HS6ST1 heparan sulfate 6-O-sulfotransferase 1 [ Homo sapiens (human) ]

    Gene ID: 9394, updated on 5-Mar-2024

    Summary

    Official Symbol
    HS6ST1provided by HGNC
    Official Full Name
    heparan sulfate 6-O-sulfotransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:5201
    See related
    Ensembl:ENSG00000136720 MIM:604846; AllianceGenome:HGNC:5201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH15; HS6ST
    Summary
    The protein encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biological activities. This enzyme is a type II integral membrane protein and is responsible for 6-O-sulfation of heparan sulfate. This enzyme does not share significant sequence similarity with other known sulfotransferases. A pseudogene located on chromosome 1 has been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 27.2), testis (RPKM 16.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See HS6ST1 in Genome Data Viewer
    Location:
    2q14.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (128265480..128318868, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (128701428..128754817, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (129023054..129076442, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16510 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:128994251-128994793 Neighboring gene ribosomal protein L21 pseudogene 34 Neighboring gene NANOG hESC enhancer GRCh37_chr2:128999497-129000000 Neighboring gene uncharacterized LOC124907886 Neighboring gene Sharpr-MPRA regulatory region 14953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129019563-129020132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129020147-129020648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129028169-129028830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129028831-129029492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129042083-129042912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129045407-129046236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129052695-129053244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129057516-129058114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129058115-129058712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129058713-129059311 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16511 Neighboring gene Sharpr-MPRA regulatory region 5144 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129067670-129068650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129068651-129069632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129080477-129081409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129102864-129103364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129119009-129119548 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129119549-129120087 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:129120088-129120626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129124244-129124934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129125695-129126536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129132078-129132952 Neighboring gene uncharacterized LOC105373610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129142763-129143262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129146579-129147236 Neighboring gene uncharacterized LOC105373611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129165673-129166670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129166671-129167666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129195850-129196350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:129196351-129196851 Neighboring gene RNA, 5S ribosomal pseudogene 103

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ25392, MGC116899, MGC116901, DKFZp547H098

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparan sulfate 6-O-sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfotransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    heparan-sulfate 6-O-sulfotransferase 1
    Names
    HS6ST-1
    heparan-sulfate 6-sulfotransferase
    NP_004798.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032966.1 RefSeqGene

      Range
      4730..58118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004807.3NP_004798.3  heparan-sulfate 6-O-sulfotransferase 1

      See identical proteins and their annotated locations for NP_004798.3

      Status: REVIEWED

      Source sequence(s)
      AC017079, BC001196, BC063521, BP219645, CV569969, DR005030
      Consensus CDS
      CCDS42748.1
      UniProtKB/Swiss-Prot
      B4DEP2, B4DJ29, O60243, Q53SL2, Q9BVI1
      Related
      ENSP00000259241.6, ENST00000259241.7
      Conserved Domains (1) summary
      pfam03567
      Location:85350
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      128265480..128318868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      128701428..128754817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)