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    Rnf111 ring finger 111 [ Mus musculus (house mouse) ]

    Gene ID: 93836, updated on 8-Jul-2021

    Summary

    Official Symbol
    Rnf111provided by MGI
    Official Full Name
    ring finger 111provided by MGI
    Primary source
    MGI:MGI:1934919
    See related
    Ensembl:ENSMUSG00000032217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ar; ARK; Arkadia
    Expression
    Ubiquitous expression in thymus adult (RPKM 22.4), spleen adult (RPKM 21.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf111 in Genome Data Viewer
    Location:
    9 D; 9 39.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70332706..70411122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70425424..70503840, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70273236..70351532, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene microRNA 5626 Neighboring gene cyclin B2 Neighboring gene predicted gene, 24615 Neighboring gene predicted gene, 23730 Neighboring gene predicted gene, 22229

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SUMO polymer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SUMO polymer binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent SMAD protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent SMAD protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent SMAD protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Arkadia
    Names
    RING finger protein 111
    RING-type E3 ubiquitin transferase Arkadia
    NP_001344423.1
    NP_001361682.1
    NP_291082.1
    XP_006511639.1
    XP_006511640.1
    XP_006511641.1
    XP_006511643.1
    XP_006511644.1
    XP_006511645.1
    XP_006511646.1
    XP_006511647.1
    XP_011241143.1
    XP_017169198.1
    XP_030100606.1
    XP_030100607.1
    XP_030100608.1
    XP_030100610.1
    XP_030100611.1
    XP_036011314.1
    XP_036011315.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357494.1NP_001344423.1  E3 ubiquitin-protein ligase Arkadia isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC157086, AC158995
      Consensus CDS
      CCDS90614.1
      Related
      ENSMUSP00000149445.2, ENSMUST00000215848.2
      Conserved Domains (3) summary
      cd16474
      Location:928972
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:665798
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    2. NM_001374753.1NP_001361682.1  E3 ubiquitin-protein ligase Arkadia isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157086, AC158995
      Consensus CDS
      CCDS90613.1
      Conserved Domains (3) summary
      cd16474
      Location:927971
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:278425
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    3. NM_033604.3NP_291082.1  E3 ubiquitin-protein ligase Arkadia isoform 1

      See identical proteins and their annotated locations for NP_291082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC157086, AC158995
      Consensus CDS
      CCDS23321.1
      UniProtKB/Swiss-Prot
      Q99ML9
      Related
      ENSMUSP00000034739.6, ENSMUST00000034739.12
      Conserved Domains (3) summary
      cd16474
      Location:936980
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:665798
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      70332706..70411122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244751.2XP_030100611.1  E3 ubiquitin-protein ligase Arkadia isoform X13

      Conserved Domains (3) summary
      cd16474
      Location:928972
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:665798
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    2. XM_036155421.1XP_036011314.1  E3 ubiquitin-protein ligase Arkadia isoform X10

      Conserved Domains (3) summary
      cd16474
      Location:937981
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:278425
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    3. XM_006511580.4XP_006511643.1  E3 ubiquitin-protein ligase Arkadia isoform X6

      Conserved Domains (3) summary
      cd16474
      Location:10271071
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:764897
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    4. XM_006511577.4XP_006511640.1  E3 ubiquitin-protein ligase Arkadia isoform X3

      Conserved Domains (2) summary
      cd16474
      Location:10361080
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    5. XM_006511576.3XP_006511639.1  E3 ubiquitin-protein ligase Arkadia isoform X1

      Conserved Domains (2) summary
      cd16474
      Location:10441088
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    6. XM_036155422.1XP_036011315.1  E3 ubiquitin-protein ligase Arkadia isoform X14

      Related
      ENSMUSP00000149501.2, ENSMUST00000213647.2
      Conserved Domains (3) summary
      cd16474
      Location:927971
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam08192
      Location:278425
      Peptidase_S64; Peptidase family S64
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    7. XM_006511581.5XP_006511644.1  E3 ubiquitin-protein ligase Arkadia isoform X7

      Conserved Domains (4) summary
      pfam05539
      Location:488661
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:10261070
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:763896
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    8. XM_030244750.1XP_030100610.1  E3 ubiquitin-protein ligase Arkadia isoform X12

      Conserved Domains (4) summary
      pfam05539
      Location:389562
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:935979
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:664797
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    9. XM_030244747.2XP_030100607.1  E3 ubiquitin-protein ligase Arkadia isoform X9

      Conserved Domains (3) summary
      pfam05539
      Location:389562
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:944988
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    10. XM_030244748.2XP_030100608.1  E3 ubiquitin-protein ligase Arkadia isoform X11

      Conserved Domains (3) summary
      cd16474
      Location:936980
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:665798
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    11. XM_006511582.4XP_006511645.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      See identical proteins and their annotated locations for XP_006511645.1

      Conserved Domains (2) summary
      cd16474
      Location:945989
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    12. XM_030244746.2XP_030100606.1  E3 ubiquitin-protein ligase Arkadia isoform X9

      Conserved Domains (3) summary
      pfam05539
      Location:389562
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:944988
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    13. XM_006511583.5XP_006511646.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      See identical proteins and their annotated locations for XP_006511646.1

      Conserved Domains (2) summary
      cd16474
      Location:945989
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    14. XM_006511584.4XP_006511647.1  E3 ubiquitin-protein ligase Arkadia isoform X8

      See identical proteins and their annotated locations for XP_006511647.1

      Conserved Domains (2) summary
      cd16474
      Location:945989
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:18289
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    15. XM_011242841.4XP_011241143.1  E3 ubiquitin-protein ligase Arkadia isoform X2

      Conserved Domains (3) summary
      pfam05539
      Location:488661
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:10431087
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    16. XM_006511578.5XP_006511641.1  E3 ubiquitin-protein ligase Arkadia isoform X4

      Conserved Domains (3) summary
      cd16474
      Location:10351079
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:764897
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
    17. XM_017313709.2XP_017169198.1  E3 ubiquitin-protein ligase Arkadia isoform X5

      Conserved Domains (4) summary
      pfam05539
      Location:488661
      Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
      cd16474
      Location:10341078
      RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
      pfam09770
      Location:763896
      PAT1; Topoisomerase II-associated protein PAT1
      pfam15303
      Location:117388
      RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
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