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    COG1 component of oligomeric golgi complex 1 [ Homo sapiens (human) ]

    Gene ID: 9382, updated on 8-Jul-2021

    Summary

    Official Symbol
    COG1provided by HGNC
    Official Full Name
    component of oligomeric golgi complex 1provided by HGNC
    Primary source
    HGNC:HGNC:6545
    See related
    Ensembl:ENSG00000166685 MIM:606973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LDLB; CDG2G
    Summary
    The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. It is thought that this protein is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates and plays a role in the organization of the Golgi-localized complex. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 16.2), testis (RPKM 14.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See COG1 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (73193055..73208507)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (71189194..71204646)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit K pseudogene 2 Neighboring gene somatostatin receptor 2 Neighboring gene family with sequence similarity 104 member A Neighboring gene chromosome 17 open reading frame 80 Neighboring gene cleavage and polyadenylation specific factor 4 like Neighboring gene Sharpr-MPRA regulatory region 4436 Neighboring gene CDC42 effector protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1381, DKFZp762L1710

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intra-Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Golgi transport complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    conserved oligomeric Golgi complex subunit 1
    Names
    COG complex subunit 1
    conserved oligomeric Golgi complex protein 1
    low density lipoprotein receptor defect B complementing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008971.1 RefSeqGene

      Range
      5022..20474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018714.3NP_061184.1  conserved oligomeric Golgi complex subunit 1

      See identical proteins and their annotated locations for NP_061184.1

      Status: REVIEWED

      Source sequence(s)
      AC097641, BC021985
      Consensus CDS
      CCDS11692.1
      UniProtKB/Swiss-Prot
      Q8WTW3
      Related
      ENSP00000299886.4, ENST00000299886.9
      Conserved Domains (1) summary
      pfam08700
      Location:1771
      Vps51; Vps51/Vps67

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      73193055..73208507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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