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    Smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 93762, updated on 12-Aug-2018

    Summary

    Official Symbol
    Smarca5provided by MGI
    Official Full Name
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5provided by MGI
    Primary source
    MGI:MGI:1935129
    See related
    Ensembl:ENSMUSG00000031715 Vega:OTTMUSG00000023886
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snf2h; MommeD4; 4933427E24Rik; D030040M08Rik; D330027N15Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 13.9) and 27 other tissues See more
    Orthologs

    Genomic context

    See Smarca5 in Genome Data Viewer
    Location:
    8; 8 C2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (80699943..80739459, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (83223842..83263358, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39209 Neighboring gene predicted gene, 46044 Neighboring gene Fras1 related extracellular matrix protein 3 Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene growth factor receptor bound protein 2-associated protein 1 Neighboring gene predicted gene, 31105

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-templated transcription, initiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chromatin assembly or disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin silencing at rDNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome positioning ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    ISWI-type complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NURF complex ISO
    Inferred from Sequence Orthology
    more info
     
    RSF complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
    Names
    mSnf2h
    sucrose nonfermenting protein 2 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053124.2NP_444354.2  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

      See identical proteins and their annotated locations for NP_444354.2

      Status: PROVISIONAL

      Source sequence(s)
      BC053069
      Consensus CDS
      CCDS22442.1
      UniProtKB/Swiss-Prot
      Q91ZW3
      Related
      ENSMUSP00000044361.8, OTTMUSP00000028263, ENSMUST00000043359.8, OTTMUST00000058353
      Conserved Domains (7) summary
      smart00717
      Location:841882
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00046
      Location:199338
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00167
      Location:843882
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00176
      Location:182462
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:481596
      Helicase_C; Helicase conserved C-terminal domain
      pfam09110
      Location:742827
      HAND; HAND
      pfam09111
      Location:8971009
      SLIDE; SLIDE

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      80699943..80739459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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