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    Sirt1 sirtuin 1 [ Mus musculus (house mouse) ]

    Gene ID: 93759, updated on 19-Sep-2021

    Summary

    Official Symbol
    Sirt1provided by MGI
    Official Full Name
    sirtuin 1provided by MGI
    Primary source
    MGI:MGI:2135607
    See related
    Ensembl:ENSMUSG00000020063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; Si; Sir2; Sir2a; SIR2L1; AA673258; Sir2alpha
    Summary
    This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Sirt1 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63154784..63174814, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63319005..63339035, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62781753..62801783, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120B22 gene Neighboring gene hect domain and RLD 4 Neighboring gene predicted gene, 51767 Neighboring gene Sirt1 promoter region Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene calcyclin binding protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150273

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables HLH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables keratin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-propionyllysine depropionylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA synthesis involved in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone H3 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3 deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within histone deacetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leptin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to testosterone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of histone H3-K9 trimethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histone H3-K9 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of skeletal muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of thyroid-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein depropionylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyrimidine dimer repair by nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rDNA heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to leptin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in triglyceride mobilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in rDNA heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-1
    Names
    NAD-dependent protein deacylase sirtuin-1
    SIR2-like protein 1
    regulatory protein SIR2 homolog 1
    sirtuin 1 ((silent mating type information regulation 2, homolog) 1
    NP_001153061.1
    NP_062786.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159589.2NP_001153061.1  NAD-dependent protein deacetylase sirtuin-1 isoform 2

      See identical proteins and their annotated locations for NP_001153061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
      Consensus CDS
      CCDS48585.1
      UniProtKB/TrEMBL
      Q3UNI1, Q3USJ2, Q3USY7
      Related
      ENSMUSP00000101082.3, ENSMUST00000105442.3
      Conserved Domains (1) summary
      cd01408
      Location:207442
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    2. NM_019812.3NP_062786.1  NAD-dependent protein deacetylase sirtuin-1 isoform 1

      See identical proteins and their annotated locations for NP_062786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
      Consensus CDS
      CCDS23898.1
      UniProtKB/Swiss-Prot
      Q923E4
      UniProtKB/TrEMBL
      Q3USJ2, Q3USY7, Q53Z05
      Related
      ENSMUSP00000020257.7, ENSMUST00000020257.13
      Conserved Domains (1) summary
      cd01408
      Location:246481
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63154784..63174814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001159590.1: Suppressed sequence

      Description
      NM_001159590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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