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    Pard3 par-3 family cell polarity regulator [ Mus musculus (house mouse) ]

    Gene ID: 93742, updated on 9-Oct-2018

    Summary

    Official Symbol
    Pard3provided by MGI
    Official Full Name
    par-3 family cell polarity regulatorprovided by MGI
    Primary source
    MGI:MGI:2135608
    See related
    Ensembl:ENSMUSG00000025812 Vega:OTTMUSG00000034639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asip; Par3; Phip; Par-3; Pard-3; Pard3a; AA960621; AI256638; D8Ertd580e
    Expression
    Ubiquitous expression in ovary adult (RPKM 7.1), bladder adult (RPKM 6.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pard3 in Genome Data Viewer
    Location:
    8 E2; 8 74.66 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (127063872..127612286)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (129587956..130136186)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38574 Neighboring gene GABA(A) receptor-associated protein like 2 pseudogene 8_1688.1 Neighboring gene predicted gene 9909 Neighboring gene predicted pseudogene 6921 Neighboring gene predicted gene, 32478 Neighboring gene predicted gene, 32532

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apical constriction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IC
    Inferred by Curator
    more info
    PubMed 
    centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment of epithelial cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelination in peripheral nervous system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cellular localization ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing, spreading of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Schmidt-Lanterman incisure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
     
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    internode region of axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral loop IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    partitioning defective 3 homolog
    Names
    atypical PKC isotype-specific-interacting protein
    ephrin-interacting protein
    par-3 (partitioning defective 3) homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013580.4NP_001013598.1  partitioning defective 3 homolog isoform 2

      See identical proteins and their annotated locations for NP_001013598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also called PAR-3o2) differs in the 5' and 3' UTR and has multiple coding region differences compared to variant 5. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus and shorter and distinct C-terminus compared to isoform 5.
      Source sequence(s)
      AC105981, AC132321
      Consensus CDS
      CCDS40523.1
      UniProtKB/Swiss-Prot
      Q99NH2
      Related
      ENSMUSP00000125612.1, OTTMUSP00000047889, ENSMUST00000160717.7
      Conserved Domains (1) summary
      cd00992
      Location:330409
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    2. NM_001013581.3NP_001013599.1  partitioning defective 3 homolog isoform 1

      See identical proteins and their annotated locations for NP_001013599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also called PAR-3o1) differs in the 5' and 3' UTR and has multiple coding region differences compared to variant 5. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus and shorter and distinct C-terminus compared to isoform 5.
      Source sequence(s)
      AC105981, AC132321
      Consensus CDS
      CCDS22789.1
      UniProtKB/Swiss-Prot
      Q99NH2
      UniProtKB/TrEMBL
      A0A0R4J1Y4
      Related
      ENSMUSP00000124162.1, OTTMUSP00000047891, ENSMUST00000162456.7
      Conserved Domains (1) summary
      cd00992
      Location:330409
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    3. NM_001122850.2NP_001116322.1  partitioning defective 3 homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding region compared to variant 5. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 5.
      Source sequence(s)
      AC105981, AC132321, AC155818, AC165964
      Consensus CDS
      CCDS52712.1
      UniProtKB/TrEMBL
      A5D6P2, E9PYJ2
      Related
      ENSMUSP00000124319.1, OTTMUSP00000047888, ENSMUST00000162907.7
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    4. NM_001309391.1NP_001296320.1  partitioning defective 3 homolog isoform 5

      See identical proteins and their annotated locations for NP_001296320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) encodes isoform 5.
      Source sequence(s)
      BC090616
      Consensus CDS
      CCDS80945.1
      UniProtKB/TrEMBL
      A5D6P2
      Related
      ENSMUSP00000125453.1, OTTMUSP00000047887, ENSMUST00000160272.7, OTTMUST00000087923
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    5. NM_001309392.1NP_001296321.1  partitioning defective 3 homolog isoform 6

      See identical proteins and their annotated locations for NP_001296321.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 5. The encoded isoform (6) is shorter than isoform 5.
      Source sequence(s)
      BC090616
      Consensus CDS
      CCDS80946.1
      UniProtKB/TrEMBL
      A5D6P2, B7ZNY3
      Related
      ENSMUSP00000026921.6, OTTMUSP00000047890, ENSMUST00000026921.12, OTTMUST00000087927
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    6. NM_001363431.1NP_001350360.1  partitioning defective 3 homolog isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame splice junction compared to variant 5. The resulting isoform (7) has the same N- and C-termini but is shorter compared to isoform 5.
      Source sequence(s)
      AC102819, AC105981, AC132321, AC155818, AC165964
      Conserved Domains (3) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam06495
      Location:11171187
      Transformer; Fruit fly transformer protein
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    7. NM_001363432.1NP_001350361.1  partitioning defective 3 homolog isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) represents the longest transcript and encodes the longest isoform (8).
      Source sequence(s)
      AC102819, AC105981, AC132321, AC155818, AC165964
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    8. NM_033620.2NP_296369.2  partitioning defective 3 homolog isoform 3

      See identical proteins and their annotated locations for NP_296369.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 5. The encoded isoform (3) is shorter than isoform 5.
      Source sequence(s)
      BC090616
      Consensus CDS
      CCDS22788.1
      UniProtKB/TrEMBL
      A5D6P2, G3XA13
      Related
      ENSMUSP00000124282.1, OTTMUSP00000047886, ENSMUST00000162309.7, OTTMUST00000087922
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      127063872..127612286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531526.2XP_006531589.1  partitioning defective 3 homolog isoform X5

      Conserved Domains (2) summary
      cd00992
      Location:437516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    2. XM_006531520.2XP_006531583.1  partitioning defective 3 homolog isoform X1

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    3. XM_006531523.2XP_006531586.1  partitioning defective 3 homolog isoform X3

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    4. XM_006531521.2XP_006531584.1  partitioning defective 3 homolog isoform X2

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    5. XM_006531524.2XP_006531587.1  partitioning defective 3 homolog isoform X4

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    6. XM_006531527.2XP_006531590.1  partitioning defective 3 homolog isoform X6

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    7. XM_006531528.2XP_006531591.1  partitioning defective 3 homolog isoform X7

      UniProtKB/TrEMBL
      B2RUK1
      Related
      ENSMUSP00000124718.1, OTTMUSP00000047892, ENSMUST00000162665.7, OTTMUST00000087929
      Conserved Domains (3) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam06495
      Location:11171187
      Transformer; Fruit fly transformer protein
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    8. XM_006531529.2XP_006531592.1  partitioning defective 3 homolog isoform X8

      Related
      ENSMUSP00000125450.1, OTTMUSP00000047902, ENSMUST00000162602.7, OTTMUST00000087940
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    9. XM_006531530.2XP_006531593.1  partitioning defective 3 homolog isoform X9

      Related
      ENSMUSP00000124934.1, OTTMUSP00000047899, ENSMUST00000159537.7, OTTMUST00000087937
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    10. XM_006531531.2XP_006531594.1  partitioning defective 3 homolog isoform X10

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    11. XM_006531532.2XP_006531595.1  partitioning defective 3 homolog isoform X11

      Related
      ENSMUSP00000125064.1, OTTMUSP00000047906, ENSMUST00000161355.7, OTTMUST00000087944
      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
    12. XM_006531533.2XP_006531596.1  partitioning defective 3 homolog isoform X12

      Conserved Domains (2) summary
      cd00992
      Location:465544
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam12053
      Location:1146
      DUF3534; Domain of unknown function (DUF3534)
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