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    Gabarapl2 GABA type A receptor associated protein like 2 [ Mus musculus (house mouse) ]

    Gene ID: 93739, updated on 18-Sep-2024

    Summary

    Official Symbol
    Gabarapl2provided by MGI
    Official Full Name
    GABA type A receptor associated protein like 2provided by MGI
    Primary source
    MGI:MGI:1890602
    See related
    Ensembl:ENSMUSG00000031950 AllianceGenome:MGI:1890602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gef2; GATE-16; 0610012F20Rik; 2900019O08Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including autophagosome assembly; autophagy of mitochondrion; and negative regulation of proteasomal protein catabolic process. Predicted to act upstream of or within intra-Golgi vesicle-mediated transport. Located in Golgi membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human GABARAPL2 (GABA type A receptor associated protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 106.0), frontal lobe adult (RPKM 66.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Gabarapl2 in Genome Data Viewer
    Location:
    8 E1; 8 58.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112667335..112679547)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111940703..111952915)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22725 Neighboring gene carbohydrate sulfotransferase 5 Neighboring gene transmembrane protein 231 Neighboring gene predicted gene, 36531 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114464460-114464569 Neighboring gene STARR-seq mESC enhancer starr_22729 Neighboring gene adenosine deaminase, tRNA-specific 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114500469-114500652 Neighboring gene STARR-positive B cell enhancer ABC_E6687 Neighboring gene STARR-positive B cell enhancer ABC_E1376 Neighboring gene lysyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102013

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylethanolamine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor-associated protein-like 2
    Names
    GABA(A) receptor-associated protein like 2
    gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2
    ganglioside expression factor 2
    golgi-associated ATPase enhancer of 16 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026693.5NP_080969.2  gamma-aminobutyric acid receptor-associated protein-like 2

      See identical proteins and their annotated locations for NP_080969.2

      Status: VALIDATED

      Source sequence(s)
      AI845404, AK134873, BC081436
      Consensus CDS
      CCDS40480.1
      UniProtKB/Swiss-Prot
      P60521
      Related
      ENSMUSP00000034428.8, ENSMUST00000034428.8
      Conserved Domains (1) summary
      cd17163
      Location:5116
      Ubl_ATG8_GABARAPL2; ubiquitin-like (Ubl) domain found in GABA type A receptor associated protein like 2 (GABARAPL2, also known as GATE16)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112667335..112679547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)