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    ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens (human) ]

    Gene ID: 9370, updated on 23-Jul-2024

    Summary

    Official Symbol
    ADIPOQprovided by HGNC
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:13633
    See related
    Ensembl:ENSG00000181092 MIM:605441; AllianceGenome:HGNC:13633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
    Summary
    This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
    Expression
    Restricted expression toward fat (RPKM 648.8) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADIPOQ in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (186842710..186858463)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (189664780..189680531)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186560499..186576252)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr3:186529516-186529618 Neighboring gene long intergenic non-protein coding RNA 2043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14988 Neighboring gene MCF2L2 pseudogene 1 Neighboring gene adiponectin enhancer region Neighboring gene ADIPOQ antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6282 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186582731-186583380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186586160-186586957 Neighboring gene CRISPRi-validated cis-regulatory element chr3.5443 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186591921-186592909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186597846-186598346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186598347-186598847 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186604299-186605262 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186605263-186606225 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:186611033-186611552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:186612594-186613114 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186614677-186615197 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:186615198-186615717 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:186615718-186616238 Neighboring gene ribosomal protein S20 pseudogene 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186626722-186627417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:186627418-186628112 Neighboring gene ribosomal protein L29 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Adiponectin deficiency
    MedGen: C2675517 OMIM: 612556 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
    EBI GWAS Catalog
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    EBI GWAS Catalog
    Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.
    EBI GWAS Catalog
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    EBI GWAS Catalog
    Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.
    EBI GWAS Catalog
    Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
    EBI GWAS Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog
    Novel locus FER is associated with serum HMW adiponectin levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sialic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of low-density lipoprotein receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of metanephric mesenchymal cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of glycogen (starch) synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lipid transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of metanephric podocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of myeloid cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of renal albumin absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to linoleic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to sucrose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adiponectin
    Names
    30 kDa adipocyte complement-related protein
    adipocyte complement-related 30 kDa protein
    adipose most abundant gene transcript 1 protein
    adipose specific collagen-like factor
    gelatin-binding protein 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021140.1 RefSeqGene

      Range
      5037..20790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177800.2NP_001171271.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_001171271.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072018, AK312868
      Consensus CDS
      CCDS3284.1
      UniProtKB/Swiss-Prot
      Q15848, Q58EX9
      UniProtKB/TrEMBL
      A8K660, B2R773
      Related
      ENSP00000389814.2, ENST00000444204.2
      Conserved Domains (2) summary
      smart00110
      Location:106242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42106
      Collagen; Collagen triple helix repeat (20 copies)
    2. NM_004797.4NP_004788.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_004788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072018, AK291525, BC096308
      Consensus CDS
      CCDS3284.1
      UniProtKB/Swiss-Prot
      Q15848, Q58EX9
      UniProtKB/TrEMBL
      A8K660, B2R773
      Related
      ENSP00000320709.2, ENST00000320741.7
      Conserved Domains (2) summary
      smart00110
      Location:106242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42106
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      186842710..186858463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      189664780..189680531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)