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    Csnk1a1 casein kinase 1, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 93687, updated on 5-Sep-2021

    Summary

    Official Symbol
    Csnk1a1provided by MGI
    Official Full Name
    casein kinase 1, alpha 1provided by MGI
    Primary source
    MGI:MGI:1934950
    See related
    Ensembl:ENSMUSG00000024576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK1a; Csnk1a; 2610208K14Rik; 4632404G05Rik; 5430427P18Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 23.9), bladder adult (RPKM 23.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Csnk1a1 in Genome Data Viewer
    Location:
    18; 18 E1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61687307..61723391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (61554236..61590320)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61715236..61747953)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46637 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 37 Neighboring gene VISTA enhancer mm36 Neighboring gene predicted gene, 41747

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC29354, MGC30571

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cilium TAS
    Traceable Author Statement
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    colocalizes_with keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase I isoform alpha; casein kinase I
    Names
    CK1
    CKI-alpha
    casein kinase I-alpha
    NP_001344427.1
    NP_001344428.1
    NP_001344429.1
    NP_666199.1
    XP_006526446.1
    XP_006526449.1
    XP_011245350.1
    XP_030106505.1
    XP_030106506.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357498.1NP_001344427.1  casein kinase I isoform alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89252.1
      Related
      ENSMUSP00000127265.2, ENSMUST00000170862.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. NM_001357499.1NP_001344428.1  casein kinase I isoform alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89251.1
      Related
      ENSMUSP00000127463.2, ENSMUST00000167187.8
      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. NM_001357500.1NP_001344429.1  casein kinase I isoform alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067
      Consensus CDS
      CCDS89254.1
      Related
      ENSMUSP00000132083.2, ENSMUST00000165721.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. NM_146087.3NP_666199.1  casein kinase I isoform alpha isoform 1

      See identical proteins and their annotated locations for NP_666199.1

      Status: VALIDATED

      Source sequence(s)
      AC153155, AI853067, AK076070, AK146873, BY065893
      Consensus CDS
      CCDS37838.1
      UniProtKB/TrEMBL
      Q6PJ87
      Related
      ENSMUSP00000128871.2, ENSMUST00000165123.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      61687307..61723391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247048.3XP_011245350.1  casein kinase I isoform X1

      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    2. XM_006526383.4XP_006526446.1  casein kinase I isoform X2

      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    3. XM_006526386.4XP_006526449.1  casein kinase I isoform X3

      Conserved Domains (1) summary
      cd14128
      Location:16309
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    4. XM_030250645.1XP_030106505.1  casein kinase I isoform X4

      Related
      ENSMUSP00000127144.2, ENSMUST00000163205.8
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha
    5. XM_030250646.1XP_030106506.1  casein kinase I isoform X5

      Related
      ENSMUSP00000110901.3, ENSMUST00000115246.9
      Conserved Domains (1) summary
      cd14128
      Location:16281
      STKc_CK1_alpha; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 alpha

    RNA

    1. XR_386022.4 RNA Sequence

    2. XR_386023.4 RNA Sequence

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