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    Selenof selenoprotein F [ Mus musculus (house mouse) ]

    Gene ID: 93684, updated on 16-Oct-2021

    Summary

    Official Symbol
    Selenofprovided by MGI
    Official Full Name
    selenoprotein Fprovided by MGI
    Primary source
    MGI:MGI:1927947
    See related
    Ensembl:ENSMUSG00000037072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sep15; 9430015P09Rik
    Summary
    The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. Knockout studies in mice also suggest a role for this gene in cataract formation and colon carcinogenesis. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Nov 2016]
    Expression
    Ubiquitous expression in placenta adult (RPKM 136.8), bladder adult (RPKM 131.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Selenof in Genome Data Viewer
    Location:
    3; 3 H2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144276188..144303438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144570427..144597677)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (144233391..144260641)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate 2-O-sulfotransferase 1 Neighboring gene predicted gene 43560 Neighboring gene predicted gene, 46829 Neighboring gene ribosomal protein L9, pseudogene 8 Neighboring gene SH3-domain GRB2-like B1 (endophilin)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables selenium binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thioredoxin peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in sperm chromatin condensation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    selenoprotein F
    Names
    15 kDa selenoprotein
    selenoprotein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053102.2NP_444332.1  selenoprotein F precursor

      See identical proteins and their annotated locations for NP_444332.1

      Status: REVIEWED

      Source sequence(s)
      AC123880, AF288740, AK159085, BY262067, CJ134973
      Consensus CDS
      CCDS17884.1
      UniProtKB/Swiss-Prot
      Q9ERR7
      Related
      ENSMUSP00000046910.7, ENSMUST00000082437.11
      Conserved Domains (1) summary
      pfam08806
      Location:85160
      Sep15_SelM; Sep15/SelM redox domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144276188..144303438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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