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    HAUS8 HAUS augmin like complex subunit 8 [ Homo sapiens (human) ]

    Gene ID: 93323, updated on 17-Jun-2024

    Summary

    Official Symbol
    HAUS8provided by HGNC
    Official Full Name
    HAUS augmin like complex subunit 8provided by HGNC
    Primary source
    HGNC:HGNC:30532
    See related
    Ensembl:ENSG00000131351 MIM:613434; AllianceGenome:HGNC:30532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DGT4; HICE1; NY-SAR-48
    Summary
    HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
    Expression
    Broad expression in testis (RPKM 8.8), lymph node (RPKM 7.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HAUS8 in Genome Data Viewer
    Location:
    19p13.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17049729..17075533, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17184651..17210456, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17160539..17186343, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene C3 and PZP like alpha-2-macroglobulin domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 835, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 823, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17062521-17063084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17071591-17072150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17072151-17072708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17137792-17138700 Neighboring gene Sharpr-MPRA regulatory region 9643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14253 Neighboring gene Sharpr-MPRA regulatory region 7940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10320 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17190569-17191106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17192643-17193192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14254 Neighboring gene myosin IXB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14255 Neighboring gene small nucleolar RNA, H/ACA box 118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17221215-17221716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17227113-17227612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17241751-17242749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17245192-17245801 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17245802-17246410 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17246411-17247020 Neighboring gene Sharpr-MPRA regulatory region 10590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17260531-17261223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:17263413-17264160 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17269991-17270808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17270809-17271626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17271627-17272442 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17288573-17288756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17291382-17291974 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:17291975-17292566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17321117-17321622 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:17325806-17326386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10322 Neighboring gene unconventional SNARE in the ER 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC20533

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of microtubule nucleation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of HAUS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitotic spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    HAUS augmin-like complex subunit 8
    Names
    HEC1/NDC80 interacting, centrosome associated 1
    HEC1/NDC80-interacting centrosome-associated protein 1
    Hec1-interacting and centrosome-associated 1
    sarcoma antigen NY-SAR-48

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011699.1NP_001011699.1  HAUS augmin-like complex subunit 8 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC040564, BI829542, BM563712, BX111116
      Consensus CDS
      CCDS46009.1
      UniProtKB/Swiss-Prot
      Q9BT25
      Related
      ENSP00000395298.1, ENST00000448593.6
    2. NM_033417.2NP_219485.1  HAUS augmin-like complex subunit 8 isoform a

      See identical proteins and their annotated locations for NP_219485.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC020908, BC040564, BI829542, BX111116
      Consensus CDS
      CCDS32948.1
      UniProtKB/Swiss-Prot
      B4DJA7, C9JBZ4, Q49AC4, Q86WF0, Q96FX3, Q9BT25
      Related
      ENSP00000253669.4, ENST00000253669.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      17049729..17075533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      17184651..17210456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)