U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CD163 CD163 molecule [ Homo sapiens (human) ]

    Gene ID: 9332, updated on 17-Jun-2024

    Summary

    Official Symbol
    CD163provided by HGNC
    Official Full Name
    CD163 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1631
    See related
    Ensembl:ENSG00000177575 MIM:605545; AllianceGenome:HGNC:1631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M130; MM130; SCARI1
    Summary
    The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in appendix (RPKM 85.9), spleen (RPKM 66.5) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD163 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (7470811..7503777, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (7484506..7517489, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7623407..7656373, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CD163 molecule like 1 Neighboring gene uncharacterized LOC101927882 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:7521391-7522590 Neighboring gene M-phase phosphoprotein 8 pseudogene Neighboring gene uncharacterized LOC124902870 Neighboring gene NANOG hESC enhancer GRCh37_chr12:7650144-7650645 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_30893 Neighboring gene MPRA-validated peak1556 silencer Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 31 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:7736568-7737767 Neighboring gene Sharpr-MPRA regulatory region 13430 Neighboring gene NIFK pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infected patient clinical samples exhibit an upregulation of CXCL10 and soluble CD163, which correlates with viral load PubMed
    Knockdown of CD163 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef downregulates CD163 expression in M2-type macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables scavenger receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    scavenger receptor cysteine-rich type 1 protein M130
    Names
    hemoglobin scavenger receptor
    macrophage-associated antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029826.1 RefSeqGene

      Range
      5042..38008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370145.1NP_001357074.1  scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

      Status: REVIEWED

      Source sequence(s)
      AC131206
      Consensus CDS
      CCDS53742.1
      UniProtKB/TrEMBL
      F5GZZ9
      Conserved Domains (1) summary
      smart00202
      Location:719819
      SR; Scavenger receptor Cys-rich
    2. NM_001370146.1NP_001357075.1  scavenger receptor cysteine-rich type 1 protein M130 isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC131206
      UniProtKB/TrEMBL
      F5GZZ9
      Conserved Domains (1) summary
      smart00202
      Location:719819
      SR; Scavenger receptor Cys-rich
    3. NM_004244.6NP_004235.4  scavenger receptor cysteine-rich type 1 protein M130 isoform a precursor

      See identical proteins and their annotated locations for NP_004235.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as long tail variant 1, represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC131206, AI129762, BC051281, DA619387, DB291765
      Consensus CDS
      CCDS8578.1
      UniProtKB/Swiss-Prot
      C9JIG2, Q07898, Q07899, Q07900, Q07901, Q2VLH7, Q86VB7
      UniProtKB/TrEMBL
      F5GZZ9
      Related
      ENSP00000352071.4, ENST00000359156.8
      Conserved Domains (2) summary
      smart00202
      Location:719819
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:724819
      SRCR; Scavenger receptor cysteine-rich domain
    4. NM_203416.4NP_981961.2  scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as short tail variant, uses an alternate splice site in the 3' coding region compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter, and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC131206, AI129762, BC051281, DA619387, DB291765, DQ058615
      Consensus CDS
      CCDS53742.1
      UniProtKB/TrEMBL
      F5GZZ9
      Related
      ENSP00000403885.2, ENST00000432237.3
      Conserved Domains (1) summary
      smart00202
      Location:719819
      SR; Scavenger receptor Cys-rich

    RNA

    1. NR_163255.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC131206

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      7470811..7503777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449278.2XP_024305046.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

      UniProtKB/TrEMBL
      C9JHR8, F5GZZ9
      Related
      ENSP00000379863.3, ENST00000396620.7
      Conserved Domains (1) summary
      smart00202
      Location:752852
      SR; Scavenger receptor Cys-rich
    2. XM_047429895.1XP_047285851.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

      UniProtKB/TrEMBL
      F5GZZ9
      Related
      ENST00000537044.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      7484506..7517489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373862.1XP_054229837.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X2

      UniProtKB/TrEMBL
      F5GZZ9
    2. XM_054373861.1XP_054229836.1  scavenger receptor cysteine-rich type 1 protein M130 isoform X1

      UniProtKB/TrEMBL
      F5GZZ9