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    CD22 CD22 molecule [ Homo sapiens (human) ]

    Gene ID: 933, updated on 17-Jun-2024

    Summary

    Official Symbol
    CD22provided by HGNC
    Official Full Name
    CD22 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1643
    See related
    Ensembl:ENSG00000012124 MIM:107266; AllianceGenome:HGNC:1643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIGLEC2; SIGLEC-2
    Summary
    Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in B cell activation; negative regulation of B cell receptor signaling pathway; and regulation of endocytosis. Located in early endosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lymph node (RPKM 101.0), ovary (RPKM 64.7) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD22 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35329187..35347361)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37873914..37892093)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35820090..35838264)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35773293-35773802 Neighboring gene hepcidin antimicrobial peptide Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14470 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35824208-35824417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35831571-35832072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14475 Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene microRNA 5196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene free fatty acid receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef B lymphocytes exposed to supernatants from HIV-1 Nef-expressing macrophages have upregulated expression of receptors CD22, CD54, and CD58 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: MAG

    Clone Names

    • FLJ22814, MGC130020

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CD4 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables CD4 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables IgM binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sialic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sialic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of B cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of immunoglobulin production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    B-cell receptor CD22
    Names
    B-lymphocyte cell adhesion molecule
    BL-CAM
    CD22 antigen
    T-cell surface antigen Leu-14
    sialic acid-binding Ig-like lectin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185099.2NP_001172028.1  B-cell receptor CD22 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK225625, AK225694, X59350
      Consensus CDS
      CCDS54248.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000442279.1, ENST00000536635.6
      Conserved Domains (5) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:518589
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    2. NM_001185100.2NP_001172029.1  B-cell receptor CD22 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC109306, BC109307, DA989528, DB333800, U62631, X59350
      Consensus CDS
      CCDS54247.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000441237.1, ENST00000544992.6
      Conserved Domains (6) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:606677
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:335400
      Ig_3; Immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    3. NM_001185101.2NP_001172030.1  B-cell receptor CD22 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001172030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC109306, DA989528, DB333800, X52785, X59350
      Consensus CDS
      CCDS54249.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000339349.6, ENST00000341773.10
      Conserved Domains (5) summary
      smart00408
      Location:431489
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:429500
      IG_like; Immunoglobulin like
      pfam07679
      Location:333412
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    4. NM_001278417.2NP_001265346.1  B-cell receptor CD22 isoform 5

      See identical proteins and their annotated locations for NP_001265346.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks the exon containing the translation initiation site and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC109306, BQ054599, CF138699, KC877723, U62631
      Consensus CDS
      CCDS62634.1
      UniProtKB/TrEMBL
      B7Z6Y6
      Related
      ENSP00000403822.2, ENST00000419549.6
      Conserved Domains (4) summary
      smart00410
      Location:434505
      IG_like; Immunoglobulin like
      pfam13927
      Location:163228
      Ig_3; Immunoglobulin domain
      cl11960
      Location:456
      Ig; Immunoglobulin domain
      cl28434
      Location:70155
      I-set; Immunoglobulin I-set domain
    5. NM_001771.4NP_001762.2  B-cell receptor CD22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001762.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK225625, AK225694, BC109306, DB333800, X59350
      Consensus CDS
      CCDS12457.1
      UniProtKB/Swiss-Prot
      F5GYU4, F5H7U3, O95699, O95701, O95702, O95703, P20273, Q01665, Q32M46, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6
      UniProtKB/TrEMBL
      Q0EAF5
      Related
      ENSP00000085219.4, ENST00000085219.10
      Conserved Domains (6) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:606677
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:335400
      Ig_3; Immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35329187..35347361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      37873914..37892093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024916.1: Suppressed sequence

      Description
      NM_024916.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.