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    PIGM phosphatidylinositol glycan anchor biosynthesis class M [ Homo sapiens (human) ]

    Gene ID: 93183, updated on 19-Sep-2024

    Summary

    Official Symbol
    PIGMprovided by HGNC
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis class Mprovided by HGNC
    Primary source
    HGNC:HGNC:18858
    See related
    Ensembl:ENSG00000143315 MIM:610273; AllianceGenome:HGNC:18858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPI-MT-I
    Summary
    This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See PIGM in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (160024953..160031990, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (159162027..159169067, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159994743..160001780, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1 Neighboring gene uncharacterized LOC124904436 Neighboring gene ribosomal protein L27a pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 2622 Neighboring gene potassium inwardly rectifying channel subfamily J member 10 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160054388-160054918 Neighboring gene potassium inwardly rectifying channel subfamily J member 9

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC29896

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha-1,4-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycolipid mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    part_of glycosylphosphatidylinositol-mannosyltransferase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    GPI mannosyltransferase 1
    Names
    DPM:GlcN-(acyl-)PI mannosyltransferase
    GPI mannosyltransferase I
    PIG-M mannosyltransferase
    dol-P-Man dependent GPI mannosyltransferase
    phosphatidylinositol-glycan biosynthesis class M protein
    NP_660150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012238.1 RefSeqGene

      Range
      5001..9322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_145167.3NP_660150.1  GPI mannosyltransferase 1

      See identical proteins and their annotated locations for NP_660150.1

      Status: REVIEWED

      Source sequence(s)
      AL513302, BC019865, BX643162
      Consensus CDS
      CCDS1192.1
      UniProtKB/Swiss-Prot
      Q9H3S5
      Related
      ENSP00000357069.2, ENST00000368090.5
      Conserved Domains (1) summary
      pfam05007
      Location:140408
      Mannosyl_trans; Mannosyltransferase (PIG-M)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      160024953..160031990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      159162027..159169067 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)