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    CD14 CD14 molecule [ Homo sapiens (human) ]

    Gene ID: 929, updated on 17-Jun-2024

    Summary

    Official Symbol
    CD14provided by HGNC
    Official Full Name
    CD14 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1628
    See related
    Ensembl:ENSG00000170458 MIM:158120; AllianceGenome:HGNC:1628
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
    Expression
    Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CD14 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (140631732..140633701, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (141157140..141159109, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (140011317..140013286, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267855 Neighboring gene HAUS augmin like complex subunit 1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:139972510-139973459 Neighboring gene Sharpr-MPRA regulatory region 15063 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene ribosomal protein L36 pseudogene 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140011403-140011904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:140011905-140012404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16452 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:140026953-140027488 Neighboring gene NADH:ubiquinone oxidoreductase subunit A2 Neighboring gene microRNA 3655 Neighboring gene IK cytokine

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef CD14 is significantly downregulated from the surface of HIV-1 Nef-expressing THP-1 monocytes compared to that from the surface of control cells PubMed
    nef HIV-1 Nef enhances membrane-bound (m) CD14 expression on monocytes but does not induce the release of soluble CD14 into the culture supernatants of PBMC; the upregulation of mCD14 expression does not involve endogenously produced IL-10 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipopolysaccharide immune receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables opsonin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptidoglycan immune receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface pattern recognition receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to diacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to lipoteichoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to triacyl bacterial lipopeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phagocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in toll-like receptor 4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of lipopolysaccharide receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of lipopolysaccharide receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    monocyte differentiation antigen CD14
    Names
    myeloid cell-specific leucine-rich glycoprotein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023178.1 RefSeqGene

      Range
      5527..6970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000591.4NP_000582.1  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_000582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, CF593452
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3
      UniProtKB/TrEMBL
      B2R888, F1C4A7
      Related
      ENSP00000304236.6, ENST00000302014.11
      Conserved Domains (2) summary
      COG4886
      Location:167332
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:196223
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_001040021.3NP_001035110.1  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_001035110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, DA426297
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3
      UniProtKB/TrEMBL
      B2R888, F1C4A7
      Related
      ENSP00000426543.2, ENST00000498971.7
      Conserved Domains (2) summary
      COG4886
      Location:167332
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:196223
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_001174104.2NP_001167575.1  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_001167575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, BP300412, DA426297
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3
      UniProtKB/TrEMBL
      B2R888, F1C4A7
      Related
      ENSP00000425447.2, ENST00000512545.2
      Conserved Domains (2) summary
      COG4886
      Location:167332
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:196223
      LRR_RI; leucine-rich repeat [structural motif]
    4. NM_001174105.2NP_001167576.1  monocyte differentiation antigen CD14 precursor

      See identical proteins and their annotated locations for NP_001167576.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, DA269805, DA426297
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571, Q53XT5, Q96FR6, Q96L99, Q9UNS3
      UniProtKB/TrEMBL
      B2R888, F1C4A7
      Related
      ENSP00000430884.2, ENST00000519715.2
      Conserved Domains (2) summary
      COG4886
      Location:167332
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:196223
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      140631732..140633701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      141157140..141159109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)