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    DNER delta/notch like EGF repeat containing [ Homo sapiens (human) ]

    Gene ID: 92737, updated on 17-Jun-2024

    Summary

    Official Symbol
    DNERprovided by HGNC
    Official Full Name
    delta/notch like EGF repeat containingprovided by HGNC
    Primary source
    HGNC:HGNC:24456
    See related
    Ensembl:ENSG00000187957 MIM:607299; AllianceGenome:HGNC:24456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bet; UNQ26
    Summary
    Predicted to enable Notch binding activity. Involved in central nervous system development. Located in dendrite; early endosome; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 69.6), adrenal (RPKM 34.4) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DNER in Genome Data Viewer
    Location:
    2q36.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (229357629..229714555, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (229840190..230197123, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230222345..230579271, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 14 Neighboring gene phosphotyrosine interaction domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 3439 Neighboring gene RN7SK pseudogene 283 Neighboring gene PID1-DNER intergenic CAGE-defined monocyte enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:230271779-230272978 Neighboring gene uncharacterized LOC124907995 Neighboring gene uncharacterized LOC107985994 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:230278032-230278250 Neighboring gene NANOG hESC enhancer GRCh37_chr2:230351166-230351667 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105373923 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230488203-230488702 Neighboring gene RNA, U7 small nuclear 9 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579954-230580727 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230579179-230579953 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230591371-230591872 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:230608102-230608922 Neighboring gene MPRA-validated peak4073 silencer Neighboring gene thyroid hormone receptor interactor 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230714872-230715551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:230715552-230716230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230765063-230765564 Neighboring gene MPRA-validated peak4074 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230785780-230786280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:230786281-230786781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17206 Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene F-box protein 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of delta/notch-like EGF repeat containing (DNER) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Notch binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables clathrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in endocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    delta and Notch-like epidermal growth factor-related receptor
    Names
    H_NH0150O02.1
    WUGSC:H_NH0150O02.1
    delta-notch-like EGF repeat-containing transmembrane

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139072.4NP_620711.3  delta and Notch-like epidermal growth factor-related receptor precursor

      See identical proteins and their annotated locations for NP_620711.3

      Status: VALIDATED

      Source sequence(s)
      BC024766, BC035009, DA115906, DA400901
      Consensus CDS
      CCDS33390.1
      UniProtKB/Swiss-Prot
      A6NP39, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8NFT8, Q8TB42, Q9NTF1, Q9UDM2
      UniProtKB/TrEMBL
      A8K0I8
      Related
      ENSP00000345229.4, ENST00000341772.5
      Conserved Domains (1) summary
      cd00054
      Location:581617
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      229357629..229714555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      229840190..230197123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)