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    MOB1B MOB kinase activator 1B [ Homo sapiens (human) ]

    Gene ID: 92597, updated on 27-Nov-2024

    Summary

    Official Symbol
    MOB1Bprovided by HGNC
    Official Full Name
    MOB kinase activator 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:29801
    See related
    Ensembl:ENSG00000173542 MIM:609282; AllianceGenome:HGNC:29801
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MATS2; MOB4A; MOBKL1A
    Summary
    The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 9.7), bone marrow (RPKM 8.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MOB1B in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70901851..70988168)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (74244289..74330605)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71768086..71853885)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene uncharacterized LOC124900711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15473 Neighboring gene Sharpr-MPRA regulatory region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71869952-71870648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21605 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:71883900-71884096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:71894495-71894995 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71924658-71925260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:71925261-71925861 Neighboring gene deoxycytidine kinase Neighboring gene solute carrier family 4 member 4 Neighboring gene uncharacterized LOC124900712

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC33910

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MOB kinase activator 1B
    Names
    MOB1 Mps One Binder homolog B
    MOB1, Mps One Binder kinase activator-like 1A
    mob1 homolog 1A
    mob1A
    mps one binder kinase activator-like 1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244766.2NP_001231695.1  MOB kinase activator 1B isoform 1

      See identical proteins and their annotated locations for NP_001231695.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC021989, AC093851, AK299481
      Consensus CDS
      CCDS58903.1
      UniProtKB/Swiss-Prot
      Q7L9L4
      Related
      ENSP00000379366.2, ENST00000396051.2
      Conserved Domains (1) summary
      pfam03637
      Location:38209
      Mob1_phocein; Mob1/phocein family
    2. NM_001244767.2NP_001231696.1  MOB kinase activator 1B isoform 3

      See identical proteins and their annotated locations for NP_001231696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and coding sequence compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC108014, AK093545
      UniProtKB/TrEMBL
      B3KSH6, D6RCK3
      Related
      ENST00000509041.5
      Conserved Domains (1) summary
      pfam03637
      Location:33139
      Mob1_phocein; Mob1/phocein family
    3. NM_173468.4NP_775739.1  MOB kinase activator 1B isoform 2

      See identical proteins and their annotated locations for NP_775739.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC021989, AC093851, BC038112
      Consensus CDS
      CCDS34002.1
      UniProtKB/Swiss-Prot
      B2R8U6, B4DRY3, Q7L9L4, Q8IY23
      Related
      ENSP00000310189.3, ENST00000309395.7
      Conserved Domains (1) summary
      pfam03637
      Location:33204
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70901851..70988168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532412.3XP_011530714.1  MOB kinase activator 1B isoform X2

      Conserved Domains (1) summary
      pfam03637
      Location:57228
      Mob1_phocein; Mob1/phocein family
    2. XM_005265709.3XP_005265766.1  MOB kinase activator 1B isoform X3

      See identical proteins and their annotated locations for XP_005265766.1

      UniProtKB/Swiss-Prot
      Q7L9L4
      Conserved Domains (1) summary
      pfam03637
      Location:38209
      Mob1_phocein; Mob1/phocein family
    3. XM_017008837.2XP_016864326.1  MOB kinase activator 1B isoform X1

      Conserved Domains (1) summary
      pfam03637
      Location:64235
      Mob1_phocein; Mob1/phocein family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      74244289..74330605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351248.1XP_054207223.1  MOB kinase activator 1B isoform X2

    2. XM_054351249.1XP_054207224.1  MOB kinase activator 1B isoform X3

    3. XM_054351247.1XP_054207222.1  MOB kinase activator 1B isoform X1