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    AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 [ Homo sapiens (human) ]

    Gene ID: 9255, updated on 5-Feb-2023

    Summary

    Official Symbol
    AIMP1provided by HGNC
    Official Full Name
    aminoacyl tRNA synthetase complex interacting multifunctional protein 1provided by HGNC
    Primary source
    HGNC:HGNC:10648
    See related
    Ensembl:ENSG00000164022 MIM:603605; AllianceGenome:HGNC:10648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p43; HLD3; EMAP2; SCYE1; EMAPII
    Summary
    The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.6), prostate (RPKM 7.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AIMP1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (106315544..106349456)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (109626616..109660528)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (107236701..107270613)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11278 Neighboring gene TBC1 domain containing kinase Neighboring gene uncharacterized LOC124900750 Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene long intergenic non-protein coding RNA 2173

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Tat tat SCYE1 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed
    matrix gag HIV-1 MA is identified to have a physical interaction with aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 (AIMP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of glucagon secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    aminoacyl tRNA synthase complex-interacting multifunctional protein 1
    Names
    ARS-interacting multifunctional protein 1
    endothelial monocyte-activating polypeptide 2
    endothelial-monocyte activating polypeptide II
    multisynthase complex auxiliary component p43
    multisynthetase complex auxiliary component p43
    small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028166.1 RefSeqGene

      Range
      5941..38847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142415.2NP_001135887.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

      See identical proteins and their annotated locations for NP_001135887.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC093680, AK297950, BC014051, BM314663, BQ447202, DC358150
      Consensus CDS
      CCDS3674.1
      UniProtKB/Swiss-Prot
      Q12904, Q96CQ9
      UniProtKB/TrEMBL
      B4DNK3
      Conserved Domains (2) summary
      PLN02610
      Location:140312
      PLN02610; probable methionyl-tRNA synthetase
      PRK00252
      Location:1578
      alaS; alanyl-tRNA synthetase; Reviewed
    2. NM_001142416.2NP_001135888.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC093680, AK303965, U10117
      Consensus CDS
      CCDS3674.1
      UniProtKB/Swiss-Prot
      Q96CQ9
      Related
      ENSP00000500620.1, ENST00000672341.1
      Conserved Domains (2) summary
      PLN02610
      Location:140312
      PLN02610; probable methionyl-tRNA synthetase
      PRK00252
      Location:1578
      alaS; alanyl-tRNA synthetase; Reviewed
    3. NM_004757.4NP_004748.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 precursor

      See identical proteins and their annotated locations for NP_004748.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC093680, AK095951, BC014051, BG941396, BM314663, BQ447202, DA211424
      Consensus CDS
      CCDS3674.1
      UniProtKB/Swiss-Prot
      Q12904, Q96CQ9
      Related
      ENSP00000350699.3, ENST00000358008.7
      Conserved Domains (2) summary
      PLN02610
      Location:140312
      PLN02610; probable methionyl-tRNA synthetase
      PRK00252
      Location:1578
      alaS; alanyl-tRNA synthetase; Reviewed

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      106315544..106349456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416410.1XP_047272366.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q96CQ9
      Related
      ENSP00000500794.1, ENST00000673123.1
    2. XM_017008835.3XP_016864324.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q12904, Q96CQ9
      Related
      ENSP00000500025.1, ENST00000671960.1
      Conserved Domains (2) summary
      PLN02610
      Location:140312
      PLN02610; probable methionyl-tRNA synthetase
      PRK00252
      Location:1578
      alaS; alanyl-tRNA synthetase; Reviewed

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      109626616..109660528
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)