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    DHRS3 dehydrogenase/reductase 3 [ Homo sapiens (human) ]

    Gene ID: 9249, updated on 6-Jun-2024

    Summary

    Official Symbol
    DHRS3provided by HGNC
    Official Full Name
    dehydrogenase/reductase 3provided by HGNC
    Primary source
    HGNC:HGNC:17693
    See related
    Ensembl:ENSG00000162496 MIM:612830; AllianceGenome:HGNC:17693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SDR1; RDH17; Rsdr1; DD83.1; SDR16C1; retSDR1; CNALPTC1
    Summary
    Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver (RPKM 41.2), fat (RPKM 39.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See DHRS3 in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12567910..12618210, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12112042..12164110, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12627939..12678216, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12568463-12568964 Neighboring gene small nucleolar RNA, H/ACA box 59A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12600378-12601026 Neighboring gene Sharpr-MPRA regulatory region 4366 Neighboring gene long intergenic non-protein coding RNA 2766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12608056-12608563 Neighboring gene Sharpr-MPRA regulatory region 1458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12612066-12613020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12613021-12613973 Neighboring gene Sharpr-MPRA regulatory region 5682 Neighboring gene RNA, U6atac small nuclear 18, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:12652795-12653294 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12663043-12663228 Neighboring gene Sharpr-MPRA regulatory region 11784 Neighboring gene microRNA 6730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:12677840-12678472 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12678473-12679104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:12679105-12679736 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12679972-12680223 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:12736484-12736819 Neighboring gene arylacetamide deacetylase like 4 Neighboring gene uncharacterized LOC124903846 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:12763477-12764676

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables all-trans-retinol dehydrogenase (NADP+) activity TAS
    Traceable Author Statement
    more info
     
    enables electron transfer activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables nucleotide binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of retinoic acid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in retinol metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in visual perception TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in photoreceptor outer segment membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    short-chain dehydrogenase/reductase 3
    Names
    copy number amplified long noncoding RNA in papillary thyroid cancer 1
    dehydrogenase/reductase (SDR family) member 3
    dehydrogenase/reductase member 3
    retinal short-chain dehydrogenase/reductase 1
    retinol dehydrogenase 17
    short chain dehydrogenase/reductase family 16C member 1
    short-chain dehydrogenase/reductase 1
    NP_001306154.1
    NP_001311299.1
    NP_004744.2
    XP_006711099.1
    XP_016858298.1
    XP_047290362.1
    XP_054195601.1
    XP_054195602.1
    XP_054195603.1
    XP_054195604.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319225.2NP_001306154.1  short-chain dehydrogenase/reductase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC254633, AK225057
      Conserved Domains (1) summary
      cd05339
      Location:1196
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    2. NM_001324370.2NP_001311299.1  short-chain dehydrogenase/reductase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC254633
      Conserved Domains (1) summary
      cd05339
      Location:1196
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    3. NM_004753.7NP_004744.2  short-chain dehydrogenase/reductase 3 isoform 1

      See identical proteins and their annotated locations for NP_004744.2

      Status: VALIDATED

      Source sequence(s)
      AC254633, BX648476
      Consensus CDS
      CCDS146.1
      UniProtKB/Swiss-Prot
      B2R7F3, O75911, Q5VUY3, Q6UY38, Q9BUC8
      UniProtKB/TrEMBL
      Q53HI7
      Related
      ENSP00000480439.1, ENST00000616661.5
      Conserved Domains (1) summary
      cd05339
      Location:53281
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      12567910..12618210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711036.3XP_006711099.1  short-chain dehydrogenase/reductase 3 isoform X3

      Conserved Domains (1) summary
      cl21454
      Location:53117
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_047434406.1XP_047290362.1  short-chain dehydrogenase/reductase 3 isoform X1

    3. XM_017002809.2XP_016858298.1  short-chain dehydrogenase/reductase 3 isoform X2

      Related
      ENSP00000519783.1, ENST00000714541.1
      Conserved Domains (1) summary
      cd05339
      Location:1196
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      12112042..12164110 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339626.1XP_054195601.1  short-chain dehydrogenase/reductase 3 isoform X4

      UniProtKB/Swiss-Prot
      B2R7F3, O75911, Q5VUY3, Q6UY38, Q9BUC8
      UniProtKB/TrEMBL
      Q53HI7
    2. XM_054339629.1XP_054195604.1  short-chain dehydrogenase/reductase 3 isoform X3

    3. XM_054339627.1XP_054195602.1  short-chain dehydrogenase/reductase 3 isoform X1

    4. XM_054339628.1XP_054195603.1  short-chain dehydrogenase/reductase 3 isoform X2