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    DLG5 discs large MAGUK scaffold protein 5 [ Homo sapiens (human) ]

    Gene ID: 9231, updated on 16-Mar-2024

    Summary

    Official Symbol
    DLG5provided by HGNC
    Official Full Name
    discs large MAGUK scaffold protein 5provided by HGNC
    Primary source
    HGNC:HGNC:2904
    See related
    Ensembl:ENSG00000151208 MIM:604090; AllianceGenome:HGNC:2904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDLG; YUVOB; LP-DLG; P-DLG5
    Summary
    This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 23.0), skin (RPKM 17.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DLG5 in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (77790791..77940736, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (78659856..78795806, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79550549..79686513, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1266, pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79568517-79569016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79591709-79592210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79592211-79592710 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79596052-79596324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79596746-79597366 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79601269-79601770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79613571-79614072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79614073-79614572 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616089-79616612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79616613-79617136 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79623439-79624198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79625716-79626473 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79627013-79628212 Neighboring gene Sharpr-MPRA regulatory region 8551 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79637563-79638502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79649557-79650232 Neighboring gene uncharacterized LOC101929347 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79651583-79652256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79660915-79661442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79661443-79661970 Neighboring gene Sharpr-MPRA regulatory region 4447 Neighboring gene NFE2L2 motif-containing MPRA enhancers 69 and 123 Neighboring gene Sharpr-MPRA regulatory region 2984 Neighboring gene RNA, 7SL, cytoplasmic 284, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79688206-79688382 Neighboring gene DLG5 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:79707975-79708512 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr10:79708513-79709050 and GRCh37_chr10:79709051-79709588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:79730866-79731376 Neighboring gene H2A.Z histone pseudogene 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79743812-79745011 Neighboring gene RNA polymerase III subunit A Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:79784551-79785750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3612

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Yuksel-Vogel-Bauer syndrome
    MedGen: CN376339 OMIM: 620703 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0583

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apical protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial tube branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment or maintenance of epithelial cell apical/basal polarity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in metanephric collecting duct development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuroepithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in polarized epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in zonula adherens assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    disks large homolog 5
    Names
    discs large protein LP-DLG
    discs large protein P-dlg
    discs, large homolog 5
    large type of P-DLG
    placenta and prostate DLG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011484.1 RefSeqGene

      Range
      4836..140800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004747.4NP_004738.3  disks large homolog 5

      See identical proteins and their annotated locations for NP_004738.3

      Status: REVIEWED

      Source sequence(s)
      AB011155, AK122931, AL391421, BC030250
      Consensus CDS
      CCDS7353.2
      UniProtKB/Swiss-Prot
      A6H8Y3, Q149N1, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM6, Q8TDM7, Q9UE73, Q9Y4E3
      Related
      ENSP00000361467.2, ENST00000372391.7
      Conserved Domains (12) summary
      cd11860
      Location:15971659
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:17321908
      GuKc; Guanylate kinase homologues
      smart00228
      Location:13471429
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:702771
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:295587
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:722790
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:17401907
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:130212
      Takusan; Takusan
      pfam07926
      Location:231353
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:14271499
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:417601
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:310449
      FliJ; Flagellar FliJ protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      77790791..77940736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425998.1XP_047281954.1  disks large homolog 5 isoform X5

    2. XM_005270276.5XP_005270333.1  disks large homolog 5 isoform X1

      See identical proteins and their annotated locations for XP_005270333.1

      Conserved Domains (12) summary
      cd11860
      Location:15931655
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:17281904
      GuKc; Guanylate kinase homologues
      smart00228
      Location:13431425
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:698767
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:291583
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:718786
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:17361903
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:130208
      Takusan; Takusan
      pfam08614
      Location:151345
      ATG16; Autophagy protein 16 (ATG16)
      pfam16610
      Location:14231495
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:413597
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:306445
      FliJ; Flagellar FliJ protein
    3. XM_006718056.4XP_006718119.1  disks large homolog 5 isoform X11

      See identical proteins and their annotated locations for XP_006718119.1

      UniProtKB/Swiss-Prot
      Q8TDM6
      Conserved Domains (11) summary
      cd11860
      Location:12571319
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:13921568
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10071089
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:702771
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:295587
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:722790
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:14001567
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:130212
      Takusan; Takusan
      pfam16610
      Location:10871159
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:417601
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:310449
      FliJ; Flagellar FliJ protein
    4. XM_011540342.2XP_011538644.1  disks large homolog 5 isoform X3

      See identical proteins and their annotated locations for XP_011538644.1

      Conserved Domains (13) summary
      cd11860
      Location:15071569
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:16421818
      GuKc; Guanylate kinase homologues
      smart00228
      Location:12571339
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:612681
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:205497
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:632700
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:16501817
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:40122
      Takusan; Takusan
      pfam07926
      Location:141263
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:13371409
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:327511
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:138236
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23733
      Location:220359
      FliJ; Flagellar FliJ protein
    5. XM_017016914.2XP_016872403.1  disks large homolog 5 isoform X5

      UniProtKB/Swiss-Prot
      Q8TDM6
      Conserved Domains (12) summary
      cd11860
      Location:14871549
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:16221798
      GuKc; Guanylate kinase homologues
      smart00228
      Location:12371319
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:592661
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:185477
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:612680
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:16301797
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:20102
      Takusan; Takusan
      pfam07926
      Location:121243
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:13171389
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:307491
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:200339
      FliJ; Flagellar FliJ protein
    6. XM_011540341.4XP_011538643.1  disks large homolog 5 isoform X2

      See identical proteins and their annotated locations for XP_011538643.1

      Conserved Domains (13) summary
      cd11860
      Location:15381600
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:16731849
      GuKc; Guanylate kinase homologues
      smart00228
      Location:12881370
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:643712
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:236528
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:663731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:16811848
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:71153
      Takusan; Takusan
      pfam07926
      Location:172294
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:13681440
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:358542
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23720
      Location:169267
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23733
      Location:251390
      FliJ; Flagellar FliJ protein
    7. XM_017016913.2XP_016872402.1  disks large homolog 5 isoform X4

    8. XM_047426000.1XP_047281956.1  disks large homolog 5 isoform X7

    9. XM_011540345.2XP_011538647.1  disks large homolog 5 isoform X7

      See identical proteins and their annotated locations for XP_011538647.1

      UniProtKB/Swiss-Prot
      Q8TDM6
      Conserved Domains (12) summary
      cd11860
      Location:14421504
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:15771753
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11921274
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:547616
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:140432
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:567635
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:15851752
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:157
      Takusan; Takusan
      pfam07926
      Location:76198
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:12721344
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:262446
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:155294
      FliJ; Flagellar FliJ protein
    10. XM_047426001.1XP_047281957.1  disks large homolog 5 isoform X8

    11. XM_011540344.3XP_011538646.1  disks large homolog 5 isoform X6

      See identical proteins and their annotated locations for XP_011538646.1

      Conserved Domains (12) summary
      cd11860
      Location:14851547
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:16201796
      GuKc; Guanylate kinase homologues
      smart00228
      Location:12351317
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:590659
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:183475
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:610678
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:16281795
      Guanylate_kin; Guanylate kinase
      pfam04822
      Location:18100
      Takusan; Takusan
      pfam07926
      Location:119241
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:13151387
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:305489
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:198337
      FliJ; Flagellar FliJ protein
    12. XM_011540347.3XP_011538649.1  disks large homolog 5 isoform X10

      See identical proteins and their annotated locations for XP_011538649.1

      Conserved Domains (10) summary
      cd11860
      Location:12911353
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:14261602
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10411123
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:396465
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:27281
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:416484
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:14341601
      Guanylate_kin; Guanylate kinase
      pfam16610
      Location:11211193
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:111295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:4143
      FliJ; Flagellar FliJ protein
    13. XM_017016915.2XP_016872404.1  disks large homolog 5 isoform X10

      Conserved Domains (10) summary
      cd11860
      Location:12911353
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:14261602
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10411123
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:396465
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:27281
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:416484
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:14341601
      Guanylate_kin; Guanylate kinase
      pfam16610
      Location:11211193
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:111295
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:4143
      FliJ; Flagellar FliJ protein
    14. XM_024448250.2XP_024304018.1  disks large homolog 5 isoform X13

      Conserved Domains (7) summary
      cd11860
      Location:11121174
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00072
      Location:12471423
      GuKc; Guanylate kinase homologues
      smart00228
      Location:862944
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:237305
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16610
      Location:9421014
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl26464
      Location:490863
      Atrophin-1; Atrophin-1 family
      cl26472
      Location:9149
      DUF3084; Protein of unknown function (DUF3084)
    15. XM_011540346.3XP_011538648.1  disks large homolog 5 isoform X9

      See identical proteins and their annotated locations for XP_011538648.1

      Conserved Domains (10) summary
      cd11860
      Location:15971656
      SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
      smart00228
      Location:13471429
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      COG0265
      Location:702771
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:295587
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:722790
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04822
      Location:130212
      Takusan; Takusan
      pfam07926
      Location:231353
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam16610
      Location:14271499
      dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
      cl12013
      Location:417601
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:310449
      FliJ; Flagellar FliJ protein
    16. XM_047426002.1XP_047281958.1  disks large homolog 5 isoform X12

    17. XM_006718057.4XP_006718120.1  disks large homolog 5 isoform X14

      See identical proteins and their annotated locations for XP_006718120.1

      Conserved Domains (6) summary
      COG0265
      Location:702771
      DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
      COG1340
      Location:295587
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:722790
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04822
      Location:130212
      Takusan; Takusan
      cl12013
      Location:417601
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23733
      Location:310449
      FliJ; Flagellar FliJ protein
    18. XM_047426003.1XP_047281959.1  disks large homolog 5 isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      78659856..78795806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367150.1XP_054223125.1  disks large homolog 5 isoform X1

    2. XM_054367162.1XP_054223137.1  disks large homolog 5 isoform X11

    3. XM_054367152.1XP_054223127.1  disks large homolog 5 isoform X3

    4. XM_054367154.1XP_054223129.1  disks large homolog 5 isoform X5

    5. XM_054367151.1XP_054223126.1  disks large homolog 5 isoform X2

    6. XM_054367153.1XP_054223128.1  disks large homolog 5 isoform X4

    7. XM_054367156.1XP_054223131.1  disks large homolog 5 isoform X7

    8. XM_054367157.1XP_054223132.1  disks large homolog 5 isoform X7

    9. XM_054367158.1XP_054223133.1  disks large homolog 5 isoform X8

    10. XM_054367155.1XP_054223130.1  disks large homolog 5 isoform X6

    11. XM_054367161.1XP_054223136.1  disks large homolog 5 isoform X10

    12. XM_054367160.1XP_054223135.1  disks large homolog 5 isoform X10

    13. XM_054367164.1XP_054223139.1  disks large homolog 5 isoform X13

    14. XM_054367159.1XP_054223134.1  disks large homolog 5 isoform X9

    15. XM_054367163.1XP_054223138.1  disks large homolog 5 isoform X12

    16. XM_054367165.1XP_054223140.1  disks large homolog 5 isoform X14

    17. XM_054367166.1XP_054223141.1  disks large homolog 5 isoform X15