U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    GGTLC1 gamma-glutamyltransferase light chain 1 [ Homo sapiens (human) ]

    Gene ID: 92086, updated on 17-Jun-2024

    Summary

    Official Symbol
    GGTLC1provided by HGNC
    Official Full Name
    gamma-glutamyltransferase light chain 1provided by HGNC
    Primary source
    HGNC:HGNC:16437
    See related
    Ensembl:ENSG00000149435 MIM:612338; AllianceGenome:HGNC:16437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GGTL6; GGTLA3; GGTLA4; dJ831C21.1; dJ831C21.2
    Summary
    This gene encodes a member of the gamma-glutamyl transpeptidase (GGT) family, which are important in the metabolism of glutathione. The most ubiquitously expressed human GGT gene, GGT1, encodes a single transmembrane polypeptide that is post-translationally processed to form a heavy and a light chain. In contrast, the product of this gene only contains homology to the light chain region, and lacks a transmembrane domain. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008]
    Expression
    Biased expression in lung (RPKM 7.4), testis (RPKM 4.4) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GGTLC1 in Genome Data Viewer
    Location:
    20p11.21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (23985053..23988779, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (24044914..24050102, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23965690..23969416, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23859878-23860707 Neighboring gene cystatin D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23870192-23870692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:23898319-23899110 Neighboring gene cystatin pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23918707-23919207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23965513-23966509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23974385-23975104 Neighboring gene uncharacterized LOC107985438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:23975825-23976543 Neighboring gene POM121 transmembrane nucleoporin like 3, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC50550

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in glutathione catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene D4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    glutathione hydrolase light chain 1
    Names
    gamma-glutamyl transpeptidase
    gamma-glutamyltransferase-like activity 3
    gamma-glutamyltransferase-like activity 4
    gamma-glutamyltransferase-like protein 6
    NP_842563.1
    NP_842564.1
    XP_005260920.1
    XP_005260921.1
    XP_005260922.1
    XP_011527693.1
    XP_011527694.1
    XP_011527695.1
    XP_016883615.1
    XP_054180181.1
    XP_054180182.1
    XP_054180183.1
    XP_054180184.1
    XP_054180185.1
    XP_054180186.1
    XP_054180187.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178311.3NP_842563.1  glutathione hydrolase light chain 1

      See identical proteins and their annotated locations for NP_842563.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.
      Source sequence(s)
      AL133466, BC040904
      Consensus CDS
      CCDS13163.1
      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8
      Related
      ENSP00000337587.4, ENST00000335694.4
      Conserved Domains (1) summary
      cl19223
      Location:1220
      G_glu_transpept; Gamma-glutamyltranspeptidase
    2. NM_178312.3NP_842564.1  glutathione hydrolase light chain 1

      See identical proteins and their annotated locations for NP_842564.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants A and B encode the same protein.
      Source sequence(s)
      BC040904, L20491
      Consensus CDS
      CCDS13163.1
      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8
      Related
      ENSP00000278765.4, ENST00000278765.8
      Conserved Domains (1) summary
      cl19223
      Location:1220
      G_glu_transpept; Gamma-glutamyltranspeptidase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      23985053..23988779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011529393.3XP_011527695.1  glutathione hydrolase light chain 1 isoform X3

      See identical proteins and their annotated locations for XP_011527695.1

      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:2190
      G_glu_transpept; Gamma-glutamyltranspeptidase
    2. XM_005260863.5XP_005260920.1  glutathione hydrolase light chain 1 isoform X1

      See identical proteins and their annotated locations for XP_005260920.1

      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:1247
      G_glu_transpept; Gamma-glutamyltranspeptidase
    3. XM_011529392.3XP_011527694.1  glutathione hydrolase light chain 1 isoform X3

      See identical proteins and their annotated locations for XP_011527694.1

      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:2190
      G_glu_transpept; Gamma-glutamyltranspeptidase
    4. XM_005260865.5XP_005260922.1  glutathione hydrolase light chain 1 isoform X2

      See identical proteins and their annotated locations for XP_005260922.1

      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:1220
      G_glu_transpept; Gamma-glutamyltranspeptidase
    5. XM_005260864.5XP_005260921.1  glutathione hydrolase light chain 1 isoform X1

      See identical proteins and their annotated locations for XP_005260921.1

      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:1247
      G_glu_transpept; Gamma-glutamyltranspeptidase
    6. XM_011529391.4XP_011527693.1  glutathione hydrolase light chain 1 isoform X1

      See identical proteins and their annotated locations for XP_011527693.1

      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:1247
      G_glu_transpept; Gamma-glutamyltranspeptidase
    7. XM_017028126.3XP_016883615.1  glutathione hydrolase light chain 1 isoform X2

      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8
      Conserved Domains (1) summary
      cl19223
      Location:1220
      G_glu_transpept; Gamma-glutamyltranspeptidase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      24044914..24050102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324210.1XP_054180185.1  glutathione hydrolase light chain 1 isoform X3

      UniProtKB/TrEMBL
      Q6ISU8
    2. XM_054324207.1XP_054180182.1  glutathione hydrolase light chain 1 isoform X1

      UniProtKB/TrEMBL
      Q6ISU8
    3. XM_054324209.1XP_054180184.1  glutathione hydrolase light chain 1 isoform X3

      UniProtKB/TrEMBL
      Q6ISU8
    4. XM_054324208.1XP_054180183.1  glutathione hydrolase light chain 1 isoform X2

      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8
    5. XM_054324206.1XP_054180181.1  glutathione hydrolase light chain 1 isoform X1

      UniProtKB/TrEMBL
      Q6ISU8
    6. XM_054324211.1XP_054180186.1  glutathione hydrolase light chain 1 isoform X1

      UniProtKB/TrEMBL
      Q6ISU8
    7. XM_054324212.1XP_054180187.1  glutathione hydrolase light chain 1 isoform X2

      UniProtKB/Swiss-Prot
      D3DW43, Q08246, Q9BX51
      UniProtKB/TrEMBL
      Q6ISU8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080920.2: Suppressed sequence

      Description
      NM_080920.2: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.