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    WDR20 WD repeat domain 20 [ Homo sapiens (human) ]

    Gene ID: 91833, updated on 3-Dec-2024

    Summary

    Official Symbol
    WDR20provided by HGNC
    Official Full Name
    WD repeat domain 20provided by HGNC
    Primary source
    HGNC:HGNC:19667
    See related
    Ensembl:ENSG00000140153 MIM:617741; AllianceGenome:HGNC:19667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DMR; Bun107
    Summary
    This gene encodes a WD repeat-containing protein that functions to preserve and regulate the activity of the USP12-UAF1 deubiquitinating enzyme complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2011]
    Expression
    Ubiquitous expression in testis (RPKM 5.3), thyroid (RPKM 3.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WDR20 in Genome Data Viewer
    Location:
    14q32.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (102139423..102224839)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (96375006..96460287)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102605760..102690010)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102515797-102516781 Neighboring gene Sharpr-MPRA regulatory region 9666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102522673-102523378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102523379-102524082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102530418-102531305 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:102550057-102551256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6109 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6110 Neighboring gene heat shock protein 90 alpha family class A member 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:102605474-102605669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102622168-102623084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102623085-102624001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102625184-102625684 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:102638165-102639150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102650679-102651180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102651181-102651680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6111 Neighboring gene uncharacterized LOC105370677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102697452-102697952 Neighboring gene MOK protein kinase Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:102745661-102746860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:102771382-102771904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:102780520-102781020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9070 Neighboring gene tRNA-Ile (anticodon AAT) 5-4 Neighboring gene zinc finger protein 839

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ27314, FLJ33659, MGC33177, MGC33183, DKFZp686B2131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables deubiquitinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WD repeat-containing protein 20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242414.2NP_001229343.1  WD repeat-containing protein 20 isoform 4

      See identical proteins and their annotated locations for NP_001229343.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the central and 3' coding regions, and in the 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct and significantly shorter C-terminus, compared to isoform 1. Variants 4 and 37 both encode the same isoform (4).
      Source sequence(s)
      AL832242, BC028387, BP363522
      Consensus CDS
      CCDS55942.1
      UniProtKB/Swiss-Prot
      Q8TBZ3
      Related
      ENSP00000299135.6, ENST00000299135.6
    2. NM_001242415.2NP_001229344.1  WD repeat-containing protein 20 isoform 5

      See identical proteins and their annotated locations for NP_001229344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct and significantly shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL359402, BC030654
      Consensus CDS
      CCDS55944.1
      UniProtKB/Swiss-Prot
      Q8TBZ3
      Related
      ENSP00000314209.5, ENST00000322340.9
    3. NM_001242416.2NP_001229345.1  WD repeat-containing protein 20 isoform 6

      See identical proteins and their annotated locations for NP_001229345.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1.
      Source sequence(s)
      AF327354, AK225852, AL832242
      Consensus CDS
      CCDS55945.1
      UniProtKB/TrEMBL
      Q59GG1
      Related
      ENSP00000450636.1, ENST00000556807.1
      Conserved Domains (3) summary
      sd00039
      Location:92157
      7WD40; WD40 repeat [structural motif]
      pfam04388
      Location:249390
      Hamartin; Hamartin protein
      cl29593
      Location:88253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001242417.2NP_001229346.1  WD repeat-containing protein 20 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (7) has a distinct and longer C-terminus, compared to isoform 1.
      Source sequence(s)
      AK297727, BC028387, BP363522
      Consensus CDS
      CCDS55943.1
      UniProtKB/Swiss-Prot
      Q8TBZ3
      Related
      ENSP00000406084.2, ENST00000454394.2
      Conserved Domains (2) summary
      sd00039
      Location:184249
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:180345
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001242418.2NP_001229347.1  WD repeat-containing protein 20 isoform 8

      See identical proteins and their annotated locations for NP_001229347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site in the 5' coding region, and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (8) is the same length but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL832500, BC028387, BP363522
      UniProtKB/TrEMBL
      Q5JPH5
      Conserved Domains (3) summary
      COG2319
      Location:159401
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:114155
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:161326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_001320130.2NP_001307059.1  WD repeat-containing protein 20 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks an exon in the coding region, compared to variant 1. The encoded isoform (10) is shorter, compared to isoform 1.
      Source sequence(s)
      AL359402, BM707311, BP363522, DR423616
      UniProtKB/TrEMBL
      H0YKE8
    7. NM_001330228.3NP_001317157.1  WD repeat-containing protein 20 isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) contains an alternate in-frame exon in the 5' coding region compared to variant 1, and encodes the longest isoform (11).
      Source sequence(s)
      AL133223, AL359402
      Consensus CDS
      CCDS81853.1
      UniProtKB/TrEMBL
      A0A088AWN2
      Related
      ENSP00000395793.3, ENST00000424963.6
    8. NM_001353656.2NP_001340585.1  WD repeat-containing protein 20 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      Conserved Domains (2) summary
      sd00039
      Location:102143
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. NM_001353657.2NP_001340586.1  WD repeat-containing protein 20 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      Conserved Domains (2) summary
      sd00039
      Location:102143
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. NM_001353658.2NP_001340587.1  WD repeat-containing protein 20 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
      Conserved Domains (2) summary
      sd00039
      Location:103168
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:99264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    11. NM_001353659.2NP_001340588.1  WD repeat-containing protein 20 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
      Conserved Domains (2) summary
      sd00039
      Location:104169
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:100265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    12. NM_001353660.2NP_001340589.1  WD repeat-containing protein 20 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
      Conserved Domains (2) summary
      sd00039
      Location:103168
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:99264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    13. NM_001353661.2NP_001340590.1  WD repeat-containing protein 20 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:2287
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:18183
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    14. NM_001353662.2NP_001340591.1  WD repeat-containing protein 20 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 19-22, encodes isoform 18.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    15. NM_001353663.2NP_001340592.1  WD repeat-containing protein 20 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 18 and 20-22, encodes isoform 18.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    16. NM_001353664.2NP_001340593.1  WD repeat-containing protein 20 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 18, 19, 21, and 22, encodes isoform 18.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    17. NM_001353665.2NP_001340594.1  WD repeat-containing protein 20 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 18-20 and 22, encodes isoform 18.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    18. NM_001353666.2NP_001340595.1  WD repeat-containing protein 20 isoform 18

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 18-21, encodes isoform 18.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    19. NM_001353667.2NP_001340596.1  WD repeat-containing protein 20 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    20. NM_001353668.2NP_001340597.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 25-30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    21. NM_001353669.2NP_001340598.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 24 and 26-30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    22. NM_001353670.2NP_001340599.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 24, 25, and 27-30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    23. NM_001353671.2NP_001340600.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 24-26 and 28-30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    24. NM_001353672.2NP_001340601.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 24-27, 29, and 30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    25. NM_001353673.2NP_001340602.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 24-28 and 30, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    26. NM_001353674.2NP_001340603.1  WD repeat-containing protein 20 isoform 20

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 24-29, encodes isoform 20.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KPG5, Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    27. NM_001353675.2NP_001340604.1  WD repeat-containing protein 20 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KQX8
      Conserved Domains (3) summary
      sd00039
      Location:942
      7WD40; WD40 repeat [structural motif]
      pfam04388
      Location:53194
      Hamartin; Hamartin protein
      cl29593
      Location:262
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    28. NM_001353676.2NP_001340605.1  WD repeat-containing protein 20 isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 33 and 34, encodes isoform 22.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KQX8
      Conserved Domains (3) summary
      sd00039
      Location:942
      7WD40; WD40 repeat [structural motif]
      pfam04388
      Location:53194
      Hamartin; Hamartin protein
      cl29593
      Location:262
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    29. NM_001353677.2NP_001340606.1  WD repeat-containing protein 20 isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 32 and 34, encodes isoform 22.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KQX8
      Conserved Domains (3) summary
      sd00039
      Location:942
      7WD40; WD40 repeat [structural motif]
      pfam04388
      Location:53194
      Hamartin; Hamartin protein
      cl29593
      Location:262
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    30. NM_001353678.2NP_001340607.1  WD repeat-containing protein 20 isoform 22

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 32 and 33, encodes isoform 22.
      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      B3KQX8
      Conserved Domains (3) summary
      sd00039
      Location:942
      7WD40; WD40 repeat [structural motif]
      pfam04388
      Location:53194
      Hamartin; Hamartin protein
      cl29593
      Location:262
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    31. NM_001353679.2NP_001340608.1  WD repeat-containing protein 20 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
      UniProtKB/TrEMBL
      H0YKE8
    32. NM_001353680.2NP_001340609.1  WD repeat-containing protein 20 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
    33. NM_001353681.2NP_001340610.1  WD repeat-containing protein 20 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (37), as well as variant 4, encodes isoform 4.
      Source sequence(s)
      AL133223, AL359402
      Consensus CDS
      CCDS55942.1
    34. NM_144574.4NP_653175.2  WD repeat-containing protein 20 isoform 2

      See identical proteins and their annotated locations for NP_653175.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL832242, BC028387
      Consensus CDS
      CCDS9969.1
      UniProtKB/Swiss-Prot
      B4DN18, E7EUY8, F8W9S4, G3V2F8, G3V5R0, H0YJJ1, Q86TU2, Q8NCN7, Q8TBZ3, Q8WXX2, Q9UF86
      Related
      ENSP00000341037.3, ENST00000342702.8
      Conserved Domains (2) summary
      sd00039
      Location:102143
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    35. NM_181291.3NP_851808.1  WD repeat-containing protein 20 isoform 1

      See identical proteins and their annotated locations for NP_851808.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AF327354, AK225852, AL832242, BP363522
      Consensus CDS
      CCDS9968.1
      UniProtKB/Swiss-Prot
      Q8TBZ3
      Related
      ENSP00000335434.5, ENST00000335263.9
      Conserved Domains (2) summary
      sd00039
      Location:102143
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:149314
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    36. NM_181308.3NP_851825.1  WD repeat-containing protein 20 isoform 3

      See identical proteins and their annotated locations for NP_851825.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region and differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC028387, BP363522, BX248274
      Consensus CDS
      CCDS9970.1
      UniProtKB/TrEMBL
      Q59GG1
      Related
      ENSP00000451633.2, ENST00000556511.2
      Conserved Domains (2) summary
      sd00039
      Location:92157
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:88253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_038354.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) includes an additional exon in the central region, and alternate exon structure in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as found in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK090580, BC028387
    2. NR_148510.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402
    3. NR_148511.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL133223, AL359402

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      102139423..102224839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449743.2XP_024305511.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_024449742.2XP_024305510.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_011537339.3XP_011535641.1  WD repeat-containing protein 20 isoform X5

      Conserved Domains (3) summary
      COG2319
      Location:190432
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:196261
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:192357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_011537335.3XP_011535637.1  WD repeat-containing protein 20 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:190432
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:196261
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:192357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_011537337.3XP_011535639.1  WD repeat-containing protein 20 isoform X3

      Conserved Domains (3) summary
      COG2319
      Location:190432
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:196261
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:192357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_011537352.4XP_011535654.1  WD repeat-containing protein 20 isoform X21

    7. XM_017021767.2XP_016877256.1  WD repeat-containing protein 20 isoform X10

    8. XM_011537356.4XP_011535658.1  WD repeat-containing protein 20 isoform X25

      UniProtKB/TrEMBL
      H0YKE8
    9. XM_047431931.1XP_047287887.1  WD repeat-containing protein 20 isoform X23

    10. XM_047431929.1XP_047287885.1  WD repeat-containing protein 20 isoform X19

    11. XM_011537341.3XP_011535643.1  WD repeat-containing protein 20 isoform X8

      Conserved Domains (3) summary
      COG2319
      Location:159401
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:114155
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:161326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    12. XM_011537343.2XP_011535645.1  WD repeat-containing protein 20 isoform X11

      Conserved Domains (3) summary
      COG2319
      Location:128370
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:134199
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:130295
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    13. XM_011537344.4XP_011535646.1  WD repeat-containing protein 20 isoform X12

      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
      Conserved Domains (3) summary
      COG2319
      Location:97339
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:103168
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:99264
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    14. XM_011537345.3XP_011535647.1  WD repeat-containing protein 20 isoform X17

      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
      Conserved Domains (2) summary
      sd00039
      Location:2994
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:25190
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    15. XM_011537338.2XP_011535640.1  WD repeat-containing protein 20 isoform X4

      See identical proteins and their annotated locations for XP_011535640.1

      Conserved Domains (2) summary
      sd00039
      Location:184249
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:180345
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    16. XM_006720308.2XP_006720371.1  WD repeat-containing protein 20 isoform X13

      See identical proteins and their annotated locations for XP_006720371.1

      Conserved Domains (3) summary
      COG2319
      Location:78328
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:92157
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:88253
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    17. XM_047431928.1XP_047287884.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    18. XM_011537336.3XP_011535638.1  WD repeat-containing protein 20 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:190432
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:196261
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:192357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    19. XM_011537340.4XP_011535642.1  WD repeat-containing protein 20 isoform X7

      Conserved Domains (3) summary
      COG2319
      Location:190432
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:196261
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:192357
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    20. XM_047431924.1XP_047287880.1  WD repeat-containing protein 20 isoform X9

    21. XM_017021785.2XP_016877274.1  WD repeat-containing protein 20 isoform X6

      Conserved Domains (3) summary
      COG2319
      Location:178420
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:184249
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:180345
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    22. XM_047431925.1XP_047287881.1  WD repeat-containing protein 20 isoform X14

      UniProtKB/TrEMBL
      Q59GG1
    23. XM_011537353.4XP_011535655.1  WD repeat-containing protein 20 isoform X22

    24. XM_047431932.1XP_047287888.1  WD repeat-containing protein 20 isoform X24

      UniProtKB/TrEMBL
      H0YKE8
    25. XM_047431933.1XP_047287889.1  WD repeat-containing protein 20 isoform X26

      UniProtKB/TrEMBL
      H0YKE8
    26. XM_047431930.1XP_047287886.1  WD repeat-containing protein 20 isoform X20

    27. XM_011537346.2XP_011535648.1  WD repeat-containing protein 20 isoform X18

      See identical proteins and their annotated locations for XP_011535648.1

      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    28. XM_006720310.2XP_006720373.1  WD repeat-containing protein 20 isoform X18

      See identical proteins and their annotated locations for XP_006720373.1

      UniProtKB/TrEMBL
      Q59GG1
      Conserved Domains (2) summary
      sd00039
      Location:5086
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:29141
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    29. XM_047431926.1XP_047287882.1  WD repeat-containing protein 20 isoform X15

      UniProtKB/TrEMBL
      Q59GG1
    30. XM_047431927.1XP_047287883.1  WD repeat-containing protein 20 isoform X16

      UniProtKB/TrEMBL
      Q59GG1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      96375006..96460287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377013.1XP_054232988.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    2. XM_054377011.1XP_054232986.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    3. XM_054376996.1XP_054232971.1  WD repeat-containing protein 20 isoform X5

    4. XM_054376992.1XP_054232967.1  WD repeat-containing protein 20 isoform X1

    5. XM_054376994.1XP_054232969.1  WD repeat-containing protein 20 isoform X3

    6. XM_054377016.1XP_054232991.1  WD repeat-containing protein 20 isoform X21

    7. XM_054377001.1XP_054232976.1  WD repeat-containing protein 20 isoform X10

    8. XM_054377020.1XP_054232995.1  WD repeat-containing protein 20 isoform X25

      UniProtKB/TrEMBL
      H0YKE8
    9. XM_054377018.1XP_054232993.1  WD repeat-containing protein 20 isoform X23

    10. XM_054377014.1XP_054232989.1  WD repeat-containing protein 20 isoform X19

    11. XM_054376999.1XP_054232974.1  WD repeat-containing protein 20 isoform X8

    12. XM_054377002.1XP_054232977.1  WD repeat-containing protein 20 isoform X11

    13. XM_054377003.1XP_054232978.1  WD repeat-containing protein 20 isoform X12

      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
    14. XM_054377008.1XP_054232983.1  WD repeat-containing protein 20 isoform X17

      UniProtKB/TrEMBL
      B3KR43, E7ETQ3
    15. XM_054376995.1XP_054232970.1  WD repeat-containing protein 20 isoform X4

    16. XM_054377004.1XP_054232979.1  WD repeat-containing protein 20 isoform X13

    17. XM_054377012.1XP_054232987.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    18. XM_054376993.1XP_054232968.1  WD repeat-containing protein 20 isoform X2

    19. XM_054377000.1XP_054232975.1  WD repeat-containing protein 20 isoform X9

    20. XM_054376997.1XP_054232972.1  WD repeat-containing protein 20 isoform X6

    21. XM_054377005.1XP_054232980.1  WD repeat-containing protein 20 isoform X14

      UniProtKB/TrEMBL
      Q59GG1
    22. XM_054376998.1XP_054232973.1  WD repeat-containing protein 20 isoform X7

    23. XM_054377017.1XP_054232992.1  WD repeat-containing protein 20 isoform X22

    24. XM_054377019.1XP_054232994.1  WD repeat-containing protein 20 isoform X24

      UniProtKB/TrEMBL
      H0YKE8
    25. XM_054377021.1XP_054232996.1  WD repeat-containing protein 20 isoform X26

      UniProtKB/TrEMBL
      H0YKE8
    26. XM_054377015.1XP_054232990.1  WD repeat-containing protein 20 isoform X20

    27. XM_054377010.1XP_054232985.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    28. XM_054377009.1XP_054232984.1  WD repeat-containing protein 20 isoform X18

      UniProtKB/TrEMBL
      Q59GG1
    29. XM_054377006.1XP_054232981.1  WD repeat-containing protein 20 isoform X15

      UniProtKB/TrEMBL
      Q59GG1
    30. XM_054377007.1XP_054232982.1  WD repeat-containing protein 20 isoform X16

      UniProtKB/TrEMBL
      Q59GG1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181302.1: Suppressed sequence

      Description
      NM_181302.1: This RefSeq was permanently suppressed because currently there is insufficient support for the protein.