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    ZW10 zw10 kinetochore protein [ Homo sapiens (human) ]

    Gene ID: 9183, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZW10provided by HGNC
    Official Full Name
    zw10 kinetochore proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13194
    See related
    Ensembl:ENSG00000086827 MIM:603954; AllianceGenome:HGNC:13194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HZW10; KNTC1AP
    Summary
    This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in testis (RPKM 9.8), skin (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZW10 in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (113733187..113773692, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (113743514..113784012, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113603909..113644414, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113560062-113560563 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:113560791-113561990 Neighboring gene transmembrane serine protease 5 Neighboring gene mitochondrial translational release factor 1 like pseudogene 1 Neighboring gene ribosomal protein S29 pseudogene 19 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5542 Neighboring gene claudin 25 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149821

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables centromeric DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic sister chromatid segregation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of attachment of spindle microtubules to kinetochore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of exit from mitosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Dsl1/NZR complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RZZ complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RZZ complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore microtubule NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    centromere/kinetochore protein zw10 homolog
    Names
    ZW10 homolog, centromere/kinetochore protein
    ZW10, kinetochore associated, homolog
    zeste white 10 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004724.4NP_004715.1  centromere/kinetochore protein zw10 homolog

      See identical proteins and their annotated locations for NP_004715.1

      Status: REVIEWED

      Source sequence(s)
      BC128264, BM833775, BQ773926, DB506745, U54996
      Consensus CDS
      CCDS8363.1
      UniProtKB/Swiss-Prot
      A1A528, O43264
      UniProtKB/TrEMBL
      B2R7C2
      Related
      ENSP00000200135.3, ENST00000200135.8
      Conserved Domains (2) summary
      pfam06248
      Location:9621
      Zw10; Centromere/kinetochore Zw10
      cl21453
      Location:598768
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      113733187..113773692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018558.3XP_016874047.1  centromere/kinetochore protein zw10 homolog isoform X1

      UniProtKB/TrEMBL
      B2R7C2
      Conserved Domains (2) summary
      pfam06248
      Location:9557
      Zw10; Centromere/kinetochore Zw10
      cl21453
      Location:534704
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      113743514..113784012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370507.1XP_054226482.1  centromere/kinetochore protein zw10 homolog isoform X1

      UniProtKB/TrEMBL
      B2R7C2