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    LIN52 lin-52 DREAM MuvB core complex component [ Homo sapiens (human) ]

    Gene ID: 91750, updated on 17-Jun-2024

    Summary

    Official Symbol
    LIN52provided by HGNC
    Official Full Name
    lin-52 DREAM MuvB core complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:19856
    See related
    Ensembl:ENSG00000205659 AllianceGenome:HGNC:19856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf46; c14_5549
    Summary
    Predicted to be involved in transcription, DNA-templated. Predicted to be located in nucleoplasm. Predicted to be part of DRM complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LIN52 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (74084956..74201493)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (68292638..68409288)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74551659..74668196)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Neighboring gene Sharpr-MPRA regulatory region 8014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5926 Neighboring gene Sharpr-MPRA regulatory regions 4216 and 10298 Neighboring gene ribosomal protein L41 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36659 Neighboring gene basal body orientation factor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:74530601-74530820 Neighboring gene aldehyde dehydrogenase 6 family member A1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8725 Neighboring gene uncharacterized LOC105370563 Neighboring gene RNY4 pseudogene 21 Neighboring gene RNA, 7SL, cytoplasmic 530, pseudogene Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene MPRA-validated peak2199 silencer Neighboring gene uncharacterized LOC105370564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:74707503-74708468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:74712311-74712812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5928 Neighboring gene visual system homeobox 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of DRM complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    protein lin-52 homolog
    Names
    lin-52 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024674.3NP_001019845.2  protein lin-52 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006349, AK023979, BC094003
      Consensus CDS
      CCDS32120.2
      UniProtKB/TrEMBL
      B3KN83
      Related
      ENSP00000451812.2, ENST00000555028.7
      Conserved Domains (1) summary
      pfam10044
      Location:14107
      LIN52; Retinal tissue protein
    2. NM_001372005.1NP_001358934.1  protein lin-52 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005484
      Conserved Domains (1) summary
      pfam10044
      Location:1494
      LIN52; Retinal tissue protein
    3. NM_001372006.1NP_001358935.1  protein lin-52 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005484, AC006349
      Conserved Domains (1) summary
      pfam10044
      Location:12105
      LIN52; Retinal tissue protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      74084956..74201493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021764.2XP_016877253.1  protein lin-52 homolog isoform X6

      Conserved Domains (1) summary
      pfam10044
      Location:1898
      LIN52; Retinal tissue protein
    2. XM_047431916.1XP_047287872.1  protein lin-52 homolog isoform X1

    3. XM_011537321.4XP_011535623.2  protein lin-52 homolog isoform X2

    4. XM_047431917.1XP_047287873.1  protein lin-52 homolog isoform X3

    5. XM_011537322.3XP_011535624.2  protein lin-52 homolog isoform X4

    6. XM_047431918.1XP_047287874.1  protein lin-52 homolog isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      68292638..68409288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376977.1XP_054232952.1  protein lin-52 homolog isoform X6

    2. XM_054376972.1XP_054232947.1  protein lin-52 homolog isoform X1

    3. XM_054376973.1XP_054232948.1  protein lin-52 homolog isoform X2

    4. XM_054376974.1XP_054232949.1  protein lin-52 homolog isoform X3

    5. XM_054376975.1XP_054232950.1  protein lin-52 homolog isoform X4

    6. XM_054376976.1XP_054232951.1  protein lin-52 homolog isoform X5