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    LMF2 lipase maturation factor 2 [ Homo sapiens (human) ]

    Gene ID: 91289, updated on 5-Mar-2024

    Summary

    Official Symbol
    LMF2provided by HGNC
    Official Full Name
    lipase maturation factor 2provided by HGNC
    Primary source
    HGNC:HGNC:25096
    See related
    Ensembl:ENSG00000100258 AllianceGenome:HGNC:25096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TMEM153; TMEM112B
    Summary
    Predicted to be involved in protein maturation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in pancreas (RPKM 20.5), spleen (RPKM 16.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    22q13.33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50502949..50507702, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (51013236..51018273, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50941378..50946131, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene myo-inositol oxygenase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13984 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50955745-50956678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50965237-50965808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19324 Neighboring gene synthesis of cytochrome C oxidase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19325 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13988 Neighboring gene thymidine phosphorylase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 

    General protein information

    Preferred Names
    lipase maturation factor 2
    Names
    transmembrane protein 112B
    transmembrane protein 153

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363816.2NP_001350745.1  lipase maturation factor 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC002942, BU628394, BX412067, HY053209, U62317
      Consensus CDS
      CCDS87035.1
      Related
      ENSP00000216080.5, ENST00000216080.5
      Conserved Domains (1) summary
      pfam06762
      Location:102563
      LMF1; Lipase maturation factor
    2. NM_033200.3NP_149977.2  lipase maturation factor 2 isoform 1

      See identical proteins and their annotated locations for NP_149977.2

      Status: VALIDATED

      Source sequence(s)
      BC002942, BI917400, BU628394, BX412067, U62317
      Consensus CDS
      CCDS14093.2
      UniProtKB/Swiss-Prot
      A6NEZ0, Q13392, Q6ZNR2, Q8WU74, Q96C62, Q9BU23
      Related
      ENSP00000424381.1, ENST00000474879.7
      Conserved Domains (1) summary
      pfam06762
      Location:127588
      LMF1; Lipase maturation factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50502949..50507702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724426.4XP_006724489.1  lipase maturation factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006724489.1

      Conserved Domains (1) summary
      pfam06762
      Location:142533
      LMF1; Lipase maturation factor
    2. XM_047441593.1XP_047297549.1  lipase maturation factor 2 isoform X3

    3. XM_047441592.1XP_047297548.1  lipase maturation factor 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      51013236..51018273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326122.1XP_054182097.1  lipase maturation factor 2 isoform X1

    2. XM_054326124.1XP_054182099.1  lipase maturation factor 2 isoform X3

    3. XM_054326123.1XP_054182098.1  lipase maturation factor 2 isoform X2