LATS1 large tumor suppressor kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LATS1provided by HGNC
Official Full Name: large tumor suppressor kinase 1provided by HGNC
Primary source: HGNC:HGNC:6514
See related: Ensembl:ENSG00000131023 MIM:603473; AllianceGenome:HGNC:6514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: wts; WARTS
Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Expression: Ubiquitous expression in ovary (RPKM 6.7), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (149658153..149718101, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (150857942..150917878, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (149979289..150039237, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
Title: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading PTPN14.
LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
Title: LncRNA HOTAIR promotes the migration and invasion of cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
Title: SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling.
m[6]A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
Title: m(6)A-induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma.
LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
Title: LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1 Phosphorylation and Subcellular Localization.
S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
Title: S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development.
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
Title: WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
Title: DNMT3B and TET1 mediated DNA methylation of LATS1 regulates BC progression via hippo signaling pathway.
Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
Title: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.
Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.
Title: Identification of a novel LATS1 variant associated with familial cerebral cavernous malformations in a Chinese family.

Submit: New GeneRIF Correction See all GeneRIFs (122)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-84591 (e-PCR)
- UniSTS:102919

G17023 (e-PCR)
- UniSTS:26390

WIAF-1623 (e-PCR)
- UniSTS:8005

LATS1__6377 (e-PCR)
- UniSTS:464037

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in hippo signaling	TAS Traceable Author Statement more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inner cell mass cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner cell mass cellular morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in mammary gland epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein localization to nucleus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid segregation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase LATS1

Names: LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; WARTS protein kinase; h-warts; large tumor suppressor homolog 1

NP_001257448.1

EC 2.7.11.1

NP_001337268.1

EC 2.7.11.1

NP_001337269.1

EC 2.7.11.1

NP_001337321.1

EC 2.7.11.1

NP_004681.1

EC 2.7.11.1

XP_006715666.1

EC 2.7.11.1

XP_011534554.1

EC 2.7.11.1

XP_016866963.1

EC 2.7.11.1

XP_016866966.1

EC 2.7.11.1

XP_016866968.1

EC 2.7.11.1

XP_024302351.1

EC 2.7.11.1

XP_047275473.1

EC 2.7.11.1

XP_047275474.1

EC 2.7.11.1

XP_047275475.1

EC 2.7.11.1

XP_047275477.1

EC 2.7.11.1

XP_047275478.1

EC 2.7.11.1

XP_054212719.1

EC 2.7.11.1

XP_054212720.1

EC 2.7.11.1

XP_054212721.1

EC 2.7.11.1

XP_054212722.1

EC 2.7.11.1

XP_054212723.1

EC 2.7.11.1

XP_054212724.1

EC 2.7.11.1

XP_054212725.1

EC 2.7.11.1

XP_054212726.1

EC 2.7.11.1

XP_054212727.1

EC 2.7.11.1

XP_054212728.1

EC 2.7.11.1

XP_054212729.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270519.2 → NP_001257448.1 serine/threonine-protein kinase LATS1 isoform 2

See identical proteins and their annotated locations for NP_001257448.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks the last four exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AF104413, AL358852, AL583963, BC002767

Consensus CDS

CCDS59040.1

UniProtKB/Swiss-Prot

O95835

Related

ENSP00000444678.1, ENST00000392273.7

Conserved Domains (3) summary

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cl26247
Location:473 → 558

DNA_pol3_delta2; DNA polymerase III, delta subunit

cl28087
Location:467 → 673

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001350339.2 → NP_001337268.1 serine/threonine-protein kinase LATS1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (4) encodes isoform 3.

Source sequence(s)

AL358852, AL583963, BX276089

Conserved Domains (3) summary

cl21453
Location:598 → 1012

PKc_like; Protein Kinases, catalytic domain

cl21463
Location:11 → 38

UBA_like_SF; UBA domain-like superfamily

cl28087
Location:343 → 491

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001350340.2 → NP_001337269.1 serine/threonine-protein kinase LATS1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) encodes isoform 4.

Source sequence(s)

AL358852, AL583963, BX276089

Conserved Domains (3) summary

cd05625
Location:598 → 979

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

cl21463
Location:11 → 38

UBA_like_SF; UBA domain-like superfamily

cl28087
Location:343 → 491

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
NM_001350392.2 → NP_001337321.1 serine/threonine-protein kinase LATS1 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (6) encodes isoform 5.

Source sequence(s)

AL358852, AL583963, BX276089

UniProtKB/TrEMBL

Q59FN4

Conserved Domains (2) summary

cd05625
Location:423 → 804

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

cl26464
Location:9 → 312

Atrophin-1; Atrophin-1 family
NM_004690.4 → NP_004681.1 serine/threonine-protein kinase LATS1 isoform 1

See identical proteins and their annotated locations for NP_004681.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF104413, AL358852, AW021064, BX276089

Consensus CDS

CCDS34551.1

UniProtKB/Swiss-Prot

O95835, Q6PKD0

Related

ENSP00000437550.1, ENST00000543571.6

Conserved Domains (3) summary

smart00220
Location:705 → 1010

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cd05625
Location:703 → 1084

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

RNA

NR_073033.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate 5' exon and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.

Source sequence(s)

AK310422, AW021064, BX276089

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

149658153..149718101 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017011474.2 → XP_016866963.1 serine/threonine-protein kinase LATS1 isoform X1

Conserved Domains (3) summary

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cl21453
Location:703 → 1117

PKc_like; Protein Kinases, catalytic domain

cl28087
Location:448 → 596

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
XM_024446583.2 → XP_024302351.1 serine/threonine-protein kinase LATS1 isoform X1

Conserved Domains (3) summary

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cl21453
Location:703 → 1117

PKc_like; Protein Kinases, catalytic domain

cl28087
Location:448 → 596

FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]
XM_047419518.1 → XP_047275474.1 serine/threonine-protein kinase LATS1 isoform X2

UniProtKB/Swiss-Prot

O95835, Q6PKD0

Related

ENSP00000253339.5, ENST00000253339.9
XM_047419517.1 → XP_047275473.1 serine/threonine-protein kinase LATS1 isoform X1
XM_047419521.1 → XP_047275477.1 serine/threonine-protein kinase LATS1 isoform X8
XM_017011479.2 → XP_016866968.1 serine/threonine-protein kinase LATS1 isoform X6

UniProtKB/TrEMBL

Q59FN4
XM_011536252.3 → XP_011534554.1 serine/threonine-protein kinase LATS1 isoform X4

UniProtKB/TrEMBL

Q59FN4

Conserved Domains (3) summary

smart00220
Location:705 → 961

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cl21453
Location:703 → 961

PKc_like; Protein Kinases, catalytic domain
XM_017011477.2 → XP_016866966.1 serine/threonine-protein kinase LATS1 isoform X3
XM_047419519.1 → XP_047275475.1 serine/threonine-protein kinase LATS1 isoform X5

UniProtKB/TrEMBL

Q59FN4
XM_006715603.4 → XP_006715666.1 serine/threonine-protein kinase LATS1 isoform X7

UniProtKB/TrEMBL

Q59FN4

Conserved Domains (3) summary

smart00220
Location:705 → 862

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14397
Location:103 → 143

UBA_LATS1; UBA domain found in vertebrate serine/threonine-protein kinase LATS1

cl21453
Location:703 → 863

PKc_like; Protein Kinases, catalytic domain
XM_047419522.1 → XP_047275478.1 serine/threonine-protein kinase LATS1 isoform X9

UniProtKB/TrEMBL

Q59FN4

RNA

XR_007059386.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

150857942..150917878 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356744.1 → XP_054212719.1 serine/threonine-protein kinase LATS1 isoform X1
XM_054356745.1 → XP_054212720.1 serine/threonine-protein kinase LATS1 isoform X1
XM_054356747.1 → XP_054212722.1 serine/threonine-protein kinase LATS1 isoform X2

UniProtKB/Swiss-Prot

O95835, Q6PKD0
XM_054356746.1 → XP_054212721.1 serine/threonine-protein kinase LATS1 isoform X1
XM_054356753.1 → XP_054212728.1 serine/threonine-protein kinase LATS1 isoform X8
XM_054356751.1 → XP_054212726.1 serine/threonine-protein kinase LATS1 isoform X6

UniProtKB/TrEMBL

Q59FN4
XM_054356749.1 → XP_054212724.1 serine/threonine-protein kinase LATS1 isoform X4

UniProtKB/TrEMBL

Q59FN4
XM_054356748.1 → XP_054212723.1 serine/threonine-protein kinase LATS1 isoform X3
XM_054356750.1 → XP_054212725.1 serine/threonine-protein kinase LATS1 isoform X5

UniProtKB/TrEMBL

Q59FN4
XM_054356752.1 → XP_054212727.1 serine/threonine-protein kinase LATS1 isoform X7

UniProtKB/TrEMBL

Q59FN4
XM_054356754.1 → XP_054212729.1 serine/threonine-protein kinase LATS1 isoform X9

UniProtKB/TrEMBL

Q59FN4