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    ZNF682 zinc finger protein 682 [ Homo sapiens (human) ]

    Gene ID: 91120, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF682provided by HGNC
    Official Full Name
    zinc finger protein 682provided by HGNC
    Primary source
    HGNC:HGNC:28857
    See related
    Ensembl:ENSG00000197124 AllianceGenome:HGNC:28857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BC39498_3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.3), skin (RPKM 2.1) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF682 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19995131..20039505, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (20142143..20177228, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20115227..20150314, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904665 Neighboring gene BCL2 interacting protein 3 pseudogene 12 Neighboring gene Sharpr-MPRA regulatory region 9515 Neighboring gene vomeronasal 1 receptor 77 pseudogene Neighboring gene uncharacterized LOC105372308 Neighboring gene BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20150084-20150660 Neighboring gene uncharacterized LOC105372309 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20162158-20162885 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20162886-20163612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:20169525-20170470 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:20170471-20171415 Neighboring gene BCL2 interacting protein 3 pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90362

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077349.1NP_001070817.1  zinc finger protein 682 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006539, AK098164, DB174863
      Consensus CDS
      CCDS42534.1
      UniProtKB/TrEMBL
      B3KUX2
      Related
      ENSP00000380348.1, ENST00000397162.5
      Conserved Domains (4) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:207413
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:183207
      zf-H2C2_2; Zinc-finger double domain
    2. NM_033196.3NP_149973.1  zinc finger protein 682 isoform 1

      See identical proteins and their annotated locations for NP_149973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC006539, DA612976, DA788529, DR002650
      Consensus CDS
      CCDS42533.1
      UniProtKB/Swiss-Prot
      B3KU64, E9PFJ5, O95780, Q96JV9
      Related
      ENSP00000380351.1, ENST00000397165.7
      Conserved Domains (5) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:239445
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:371391
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:215239
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      19995131..20039505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439655.1XP_047295611.1  zinc finger protein 682 isoform X1

    2. XM_047439657.1XP_047295613.1  zinc finger protein 682 isoform X2

    3. XM_047439658.1XP_047295614.1  zinc finger protein 682 isoform X2

    4. XM_047439656.1XP_047295612.1  zinc finger protein 682 isoform X2

      Related
      ENSP00000471717.1, ENST00000595736.1

    RNA

    1. XR_007067033.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      20142143..20177228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322560.1XP_054178535.1  zinc finger protein 682 isoform X1

    2. XM_054322561.1XP_054178536.1  zinc finger protein 682 isoform X1

    3. XM_054322563.1XP_054178538.1  zinc finger protein 682 isoform X2

    4. XM_054322564.1XP_054178539.1  zinc finger protein 682 isoform X2

    5. XM_054322562.1XP_054178537.1  zinc finger protein 682 isoform X2