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    CCT6A chaperonin containing TCP1 subunit 6A [ Homo sapiens (human) ]

    Gene ID: 908, updated on 7-Oct-2018

    Summary

    Official Symbol
    CCT6Aprovided by HGNC
    Official Full Name
    chaperonin containing TCP1 subunit 6Aprovided by HGNC
    Primary source
    HGNC:HGNC:1620
    See related
    Ensembl:ENSG00000146731 MIM:104613; Vega:OTTHUMG00000022842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta
    Summary
    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in appendix (RPKM 44.1), lymph node (RPKM 38.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See CCT6A in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (56051685..56063989)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (56119378..56131682)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 2 Neighboring gene phosphoserine phosphatase Neighboring gene small nucleolar RNA, H/ACA box 22B Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase catalytic subunit gamma 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of HIV-1 Tat upregulates the abundance of chaperonin containing TCP1, subunit 6A (CCT6A) in the nucleoli of Jurkat T-cells PubMed
    Vif vif HIV-1 Vif interacts with CCT6A PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126214, MGC126215

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    WD40-repeat domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperonin-containing T-complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit zeta
    Names
    T-complex protein 1, zeta subunit
    acute morphine dependence related protein 2
    amino acid transport defect-complementing
    chaperonin containing T-complex subunit 6
    chaperonin containing TCP1, subunit 6A (zeta 1)
    histidine transport regulator 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009186.1NP_001009186.1  T-complex protein 1 subunit zeta isoform b

      See identical proteins and their annotated locations for NP_001009186.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).
      Source sequence(s)
      AC092101, AW411253, BI464886, BU540578
      Consensus CDS
      CCDS34640.1
      UniProtKB/Swiss-Prot
      P40227
      Related
      ENSP00000352019.2, OTTHUMP00000209314, ENST00000335503.3, OTTHUMT00000343286
      Conserved Domains (1) summary
      cl02777
      Location:3485
      chaperonin_like; chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I ...
    2. NM_001762.3NP_001753.1  T-complex protein 1 subunit zeta isoform a

      See identical proteins and their annotated locations for NP_001753.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC092101, AC092579, AW411253, BI464886
      Consensus CDS
      CCDS5523.1
      UniProtKB/Swiss-Prot
      P40227
      UniProtKB/TrEMBL
      A0A024RDL1
      Related
      ENSP00000275603.4, OTTHUMP00000159736, ENST00000275603.8, OTTHUMT00000251526
      Conserved Domains (1) summary
      TIGR02347
      Location:3530
      chap_CCT_zeta; T-complex protein 1, zeta subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      56051685..56063989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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