U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    EFCAB12 EF-hand calcium binding domain 12 [ Homo sapiens (human) ]

    Gene ID: 90288, updated on 17-Jun-2024

    Summary

    Official Symbol
    EFCAB12provided by HGNC
    Official Full Name
    EF-hand calcium binding domain 12provided by HGNC
    Primary source
    HGNC:HGNC:28061
    See related
    Ensembl:ENSG00000172771 AllianceGenome:HGNC:28061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C3orf25
    Summary
    Predicted to enable calcium ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 1.8), prostate (RPKM 1.5) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EFCAB12 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (129401321..129428636, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132146154..132175347, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129120164..129147479, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129066385-129066884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129072356-129072856 Neighboring gene MARK2 pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129076650-129077534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129084869-129085400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129085401-129085930 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:129107257-129108456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129113559-129114255 Neighboring gene ribosomal protein L32 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 7B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129129626-129130126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129137243-129137742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20517 Neighboring gene Sharpr-MPRA regulatory region 8693 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:129168229-129168945 Neighboring gene methyl-CpG binding domain 4, DNA glycosylase Neighboring gene intraflagellar transport 122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129200162-129201039 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:129208521-129208729 Neighboring gene Sharpr-MPRA regulatory region 10640 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:129213542-129214741

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of chromosome 3 open reading frame 25 (C3orf25) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    EF-hand calcium-binding domain-containing protein 12
    Names
    EF-hand domain-containing protein C3orf25

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207307.3NP_997190.1  EF-hand calcium-binding domain-containing protein 12

      See identical proteins and their annotated locations for NP_997190.1

      Status: VALIDATED

      Source sequence(s)
      AK127968, BC066975
      Consensus CDS
      CCDS54638.1
      UniProtKB/Swiss-Prot
      Q69YX4, Q6NXP0
      UniProtKB/TrEMBL
      B3KXU6
      Related
      ENSP00000420854.1, ENST00000505956.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      129401321..129428636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      132146154..132175347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348318.1XP_054204293.1  EF-hand calcium-binding domain-containing protein 12 isoform X2

      UniProtKB/TrEMBL
      B3KXU6
    2. XM_054348319.1XP_054204294.1  EF-hand calcium-binding domain-containing protein 12 isoform X3

      UniProtKB/TrEMBL
      B3KXU6
    3. XM_054348321.1XP_054204296.1  EF-hand calcium-binding domain-containing protein 12 isoform X5

    4. XM_054348320.1XP_054204295.1  EF-hand calcium-binding domain-containing protein 12 isoform X4

    5. XM_054348317.1XP_054204292.1  EF-hand calcium-binding domain-containing protein 12 isoform X1

      UniProtKB/TrEMBL
      B3KXU6
    6. XM_054348323.1XP_054204298.1  EF-hand calcium-binding domain-containing protein 12 isoform X7

    7. XM_054348322.1XP_054204297.1  EF-hand calcium-binding domain-containing protein 12 isoform X6