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    TAF1B TATA-box binding protein associated factor, RNA polymerase I subunit B [ Homo sapiens (human) ]

    Gene ID: 9014, updated on 5-Mar-2024

    Summary

    Official Symbol
    TAF1Bprovided by HGNC
    Official Full Name
    TATA-box binding protein associated factor, RNA polymerase I subunit Bprovided by HGNC
    Primary source
    HGNC:HGNC:11533
    See related
    Ensembl:ENSG00000115750 MIM:604904; AllianceGenome:HGNC:11533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SL1; RAF1B; RAFI63; TAFI63; MGC:9349
    Summary
    Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in testis (RPKM 5.9), placenta (RPKM 5.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TAF1B in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (9843442..9934416)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (9871368..9962349)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9983571..10074545)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996549 Neighboring gene Sharpr-MPRA regulatory region 12215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9905902-9906452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11140 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9910317-9911245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9911246-9912173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15295 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9939945-9940780 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9940781-9941616 Neighboring gene uncharacterized LOC105373421 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9949571-9950071 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:9959896-9961095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9970201-9970740 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:9974742-9974950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10057557-10058058 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10073172-10073377 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10078385-10078724 Neighboring gene uncharacterized LOC105373422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10080877-10081377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11149 Neighboring gene grainyhead like transcription factor 1 Neighboring gene uncharacterized LOC124905970

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA polymerase I core promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase I core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables TBP-class protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase I core factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase I core factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase transcription factor SL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    TATA box-binding protein-associated factor RNA polymerase I subunit B
    Names
    RNA polymerase I-specific TBP-associated factor 63 kDa
    SL1, 63kD subunit
    TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kD
    TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
    TATA box-binding protein-associated factor 1B
    TATA-box binding protein associated factor, RNA polymerase I, B
    TBP-associated factor 1B
    transcription initiation factor SL1/TIF-IB subunit B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318976.1NP_001305905.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AA746267, AC010969, AK295402, AK308070, DA910748
      UniProtKB/Swiss-Prot
      Q53T94
    2. NM_001318977.1NP_001305906.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AA746267, AC010969, AK026521, AK308070, DA910748
    3. NM_005680.3NP_005671.3  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC010969
      Consensus CDS
      CCDS33143.1
      UniProtKB/Swiss-Prot
      B4DI42, F8WD72, Q15574, Q53T94, Q8WVC3
      Related
      ENSP00000263663.4, ENST00000263663.10
      Conserved Domains (1) summary
      pfam11781
      Location:739
      zf-RRN7; Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      9843442..9934416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510410.3XP_011508712.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X1

      Conserved Domains (1) summary
      pfam11781
      Location:639
      RRN7; RNA polymerase I-specific transcription initiation factor Rrn7
    2. XM_047446254.1XP_047302210.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      9871368..9962349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344423.1XP_054200398.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X1

    2. XM_054344424.1XP_054200399.1  TATA box-binding protein-associated factor RNA polymerase I subunit B isoform X2