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    CCNG2 cyclin G2 [ Homo sapiens (human) ]

    Gene ID: 901, updated on 3-Apr-2024

    Summary

    Official Symbol
    CCNG2provided by HGNC
    Official Full Name
    cyclin G2provided by HGNC
    Primary source
    HGNC:HGNC:1593
    See related
    Ensembl:ENSG00000138764 MIM:603203; AllianceGenome:HGNC:1593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 25.3), prostate (RPKM 20.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    Location:
    4q21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (77157207..77170060)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (80498001..80510854)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (78078360..78091213)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin family domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21637 Neighboring gene RNA, U6 small nuclear 1187, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15501 Neighboring gene uncharacterized LOC101928864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15503 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15504 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:78095614-78096260 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:78096261-78096907 Neighboring gene uncharacterized LOC107986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21638 Neighboring gene ferritin light chain pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of cyclin G2 (CCNG2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004354.3NP_004345.1  cyclin-G2

      See identical proteins and their annotated locations for NP_004345.1

      Status: REVIEWED

      Source sequence(s)
      AC104771, CA429362, DC344594, U47414
      Consensus CDS
      CCDS3581.1
      UniProtKB/Swiss-Prot
      B4DF25, Q16589, Q6FGA7, Q6FGC6
      UniProtKB/TrEMBL
      Q8N5D4
      Related
      ENSP00000315743.5, ENST00000316355.10
      Conserved Domains (1) summary
      cd20584
      Location:55150
      CYCLIN_CCNG2; cyclin box found in cyclin-G2 (CCNG2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      77157207..77170060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532399.3XP_011530701.1  cyclin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011530701.1

      UniProtKB/Swiss-Prot
      B4DF25, Q16589, Q6FGA7, Q6FGC6
      UniProtKB/TrEMBL
      Q8N5D4
      Conserved Domains (1) summary
      cd20584
      Location:55150
      CYCLIN_CCNG2; cyclin box found in cyclin-G2 (CCNG2) and similar proteins
    2. XM_011532398.2XP_011530700.1  cyclin-G2 isoform X1

      See identical proteins and their annotated locations for XP_011530700.1

      UniProtKB/Swiss-Prot
      B4DF25, Q16589, Q6FGA7, Q6FGC6
      UniProtKB/TrEMBL
      Q8N5D4
      Related
      ENSP00000379002.1, ENST00000395640.5
      Conserved Domains (1) summary
      cd20584
      Location:55150
      CYCLIN_CCNG2; cyclin box found in cyclin-G2 (CCNG2) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      80498001..80510854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351195.1XP_054207170.1  cyclin-G2 isoform X1

      UniProtKB/Swiss-Prot
      B4DF25, Q16589, Q6FGA7, Q6FGC6
    2. XM_054351194.1XP_054207169.1  cyclin-G2 isoform X1

      UniProtKB/Swiss-Prot
      B4DF25, Q16589, Q6FGA7, Q6FGC6