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    KLC4 kinesin light chain 4 [ Homo sapiens (human) ]

    Gene ID: 89953, updated on 5-Mar-2024

    Summary

    Official Symbol
    KLC4provided by HGNC
    Official Full Name
    kinesin light chain 4provided by HGNC
    Primary source
    HGNC:HGNC:21624
    See related
    Ensembl:ENSG00000137171 AllianceGenome:HGNC:21624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KNSL8; bA387M24.3
    Summary
    Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    6p21.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43059631..43075093)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42888702..42903839)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43027369..43042831)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901318 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43013559-43013750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43018382-43018882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43018883-43019383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43019933-43020768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17217 Neighboring gene cullin 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43027385-43028336 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene Sharpr-MPRA regulatory region 10128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43038920-43039420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43043187-43043710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17218 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43049243-43049446 Neighboring gene KLC4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43050481-43051047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43051048-43051613 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43057365-43057958 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43057959-43058553 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43058554-43059147 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43086921-43087840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43087841-43088760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43099803-43100304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43100305-43100804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24592 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43138211-43138940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17219 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43139967-43140935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43145601-43146102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43146103-43146602 Neighboring gene serum response factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC111777

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinesin light chain 4
    Names
    kinesin-like protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289034.2NP_001275963.1  kinesin light chain 4 isoform a

      See identical proteins and their annotated locations for NP_001275963.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AK056393, BC080637, BX640717
      Consensus CDS
      CCDS4883.1
      UniProtKB/Swiss-Prot
      B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
      Related
      ENSP00000418031.1, ENST00000479388.5
      Conserved Domains (3) summary
      TIGR02168
      Location:33148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294368
      TPR_12; Tetratricopeptide repeat
    2. NM_001289035.2NP_001275964.1  kinesin light chain 4 isoform d

      See identical proteins and their annotated locations for NP_001275964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform d, which is shorter than isoform b.
      Source sequence(s)
      AK297433, BC080637
      Consensus CDS
      CCDS75459.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000395806.2, ENST00000453940.6
      Conserved Domains (2) summary
      sd00006
      Location:218246
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:217291
      TPR_12; Tetratricopeptide repeat
    3. NM_138343.4NP_612352.1  kinesin light chain 4 isoform c

      See identical proteins and their annotated locations for NP_612352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and contains a 3' terminal exon that extends past a splice site, compared to variant 3. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform b.
      Source sequence(s)
      BC012357, DA782235
      Consensus CDS
      CCDS47429.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000410358.2, ENST00000458460.6
      Conserved Domains (3) summary
      TIGR02168
      Location:33148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:212239
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:210285
      TPR_12; Tetratricopeptide repeat
    4. NM_201521.3NP_958929.1  kinesin light chain 4 isoform a

      See identical proteins and their annotated locations for NP_958929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
      Source sequence(s)
      BC080637, DA782235
      Consensus CDS
      CCDS4883.1
      UniProtKB/Swiss-Prot
      B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
      Related
      ENSP00000340221.5, ENST00000347162.10
      Conserved Domains (3) summary
      TIGR02168
      Location:33148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294368
      TPR_12; Tetratricopeptide repeat
    5. NM_201522.3NP_958930.1  kinesin light chain 4 isoform a

      See identical proteins and their annotated locations for NP_958930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AK055293, AK056393, BC080637, DA835055
      Consensus CDS
      CCDS4883.1
      UniProtKB/Swiss-Prot
      B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
      Related
      ENSP00000377620.2, ENST00000394056.6
      Conserved Domains (3) summary
      TIGR02168
      Location:33148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294368
      TPR_12; Tetratricopeptide repeat
    6. NM_201523.3NP_958931.1  kinesin light chain 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (b).
      Source sequence(s)
      AK094102, BC080637
      Consensus CDS
      CCDS4882.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000259708.3, ENST00000259708.7
      Conserved Domains (3) summary
      sd00006
      Location:313341
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:312386
      TPR_12; Tetratricopeptide repeat
      cl25732
      Location:51166
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43059631..43075093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      42888702..42903839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)