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    RHOT2 ras homolog family member T2 [ Homo sapiens (human) ]

    Gene ID: 89941, updated on 17-Jun-2024

    Summary

    Official Symbol
    RHOT2provided by HGNC
    Official Full Name
    ras homolog family member T2provided by HGNC
    Primary source
    HGNC:HGNC:21169
    See related
    Ensembl:ENSG00000140983 MIM:613889; AllianceGenome:HGNC:21169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RASL; ARHT2; MIRO2; MIRO-2; C16orf39
    Summary
    This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in spleen (RPKM 20.5), duodenum (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RHOT2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (668083..674174)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (672158..678249)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (718083..724174)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene WD repeat domain 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:724963-725497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1 Neighboring gene STUB1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial outer membrane permeabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    mitochondrial Rho GTPase 2
    Names
    mitochondrial Rho (MIRO) GTPase 2
    ras homolog gene family, member T2
    NP_001339204.1
    NP_001339205.1
    NP_001339206.1
    NP_001339207.1
    NP_001339208.1
    NP_001339209.1
    NP_001339210.1
    NP_001339211.1
    NP_001339212.1
    NP_001339213.1
    NP_001339214.1
    NP_001339215.1
    NP_001339216.1
    NP_001339217.1
    NP_001339218.1
    NP_001339219.1
    NP_001339220.1
    NP_001339221.1
    NP_001339222.1
    NP_001339223.1
    NP_620124.1
    XP_047290796.1
    XP_047290797.1
    XP_047290798.1
    XP_047290799.1
    XP_047290800.1
    XP_047290801.1
    XP_047290802.1
    XP_047290803.1
    XP_047290804.1
    XP_054170254.1
    XP_054170255.1
    XP_054170256.1
    XP_054170257.1
    XP_054170258.1
    XP_054170259.1
    XP_054170260.1
    XP_054170261.1
    XP_054170262.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031824.1 RefSeqGene

      Range
      5050..11089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001352275.2NP_001339204.1  mitochondrial Rho GTPase 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Consensus CDS
      CCDS92073.1
      UniProtKB/TrEMBL
      A0A8V8TM48
      Related
      ENSP00000513180.1, ENST00000697194.1
      Conserved Domains (4) summary
      cd01892
      Location:414590
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:342408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221306
      EF_assoc_2; EF hand associated
    2. NM_001352276.2NP_001339205.1  mitochondrial Rho GTPase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:396572
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:324390
      EF_assoc_1; EF hand associated
      pfam08356
      Location:203288
      EF_assoc_2; EF hand associated
    3. NM_001352277.2NP_001339206.1  mitochondrial Rho GTPase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:395571
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:323389
      EF_assoc_1; EF hand associated
      pfam08356
      Location:202287
      EF_assoc_2; EF hand associated
    4. NM_001352278.2NP_001339207.1  mitochondrial Rho GTPase 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:380556
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:308374
      EF_assoc_1; EF hand associated
      pfam08356
      Location:187272
      EF_assoc_2; EF hand associated
    5. NM_001352279.2NP_001339208.1  mitochondrial Rho GTPase 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:362538
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:290356
      EF_assoc_1; EF hand associated
      pfam08356
      Location:169254
      EF_assoc_2; EF hand associated
    6. NM_001352280.2NP_001339209.1  mitochondrial Rho GTPase 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:307483
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:235301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:114199
      EF_assoc_2; EF hand associated
      cl21455
      Location:962
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    7. NM_001352281.2NP_001339210.1  mitochondrial Rho GTPase 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Related
      ENST00000569675.5
      Conserved Domains (4) summary
      cd01892
      Location:306482
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:234301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:113196
      EF_assoc_2; EF hand associated
      cl38936
      Location:962
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    8. NM_001352282.2NP_001339211.1  mitochondrial Rho GTPase 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:306482
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:234301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:113196
      EF_assoc_2; EF hand associated
      cl38936
      Location:962
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    9. NM_001352283.2NP_001339212.1  mitochondrial Rho GTPase 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:286462
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:214280
      EF_assoc_1; EF hand associated
      pfam08356
      Location:93178
      EF_assoc_2; EF hand associated
      cl21455
      Location:142
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    10. NM_001352284.2NP_001339213.1  mitochondrial Rho GTPase 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:274450
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:202268
      EF_assoc_1; EF hand associated
      pfam08356
      Location:81166
      EF_assoc_2; EF hand associated
      cl21455
      Location:962
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    11. NM_001352285.2NP_001339214.1  mitochondrial Rho GTPase 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:273449
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:201267
      EF_assoc_1; EF hand associated
      pfam08356
      Location:80165
      EF_assoc_2; EF hand associated
      cl21455
      Location:962
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    12. NM_001352286.2NP_001339215.1  mitochondrial Rho GTPase 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:254430
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:182248
      EF_assoc_1; EF hand associated
      pfam08356
      Location:61146
      EF_assoc_2; EF hand associated
      cl21455
      Location:142
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    13. NM_001352287.1NP_001339216.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL834163, Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    14. NM_001352288.2NP_001339217.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    15. NM_001352289.2NP_001339218.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    16. NM_001352290.2NP_001339219.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    17. NM_001352291.2NP_001339220.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    18. NM_001352292.2NP_001339221.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    19. NM_001352293.2NP_001339222.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    20. NM_001352294.2NP_001339223.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:2884
      EF_assoc_2; EF hand associated
    21. NM_138769.3NP_620124.1  mitochondrial Rho GTPase 2 isoform 2

      See identical proteins and their annotated locations for NP_620124.1

      Status: REVIEWED

      Source sequence(s)
      AJ517413, AL834163, AY207375, DB465261
      Consensus CDS
      CCDS10417.1
      UniProtKB/Swiss-Prot
      A2IDC2, Q8IXI1, Q8NF53, Q96C13, Q96S17, Q9BT60, Q9H7M8
      Related
      ENSP00000321971.4, ENST00000315082.9
      Conserved Domains (4) summary
      cd01892
      Location:413589
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:341407
      EF_assoc_1; EF hand associated
      pfam08356
      Location:220305
      EF_assoc_2; EF hand associated

    RNA

    1. NR_147953.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    2. NR_147954.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    3. NR_147955.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    4. NR_147956.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      668083..674174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434843.1XP_047290799.1  mitochondrial Rho GTPase 2 isoform X2

    2. XM_047434844.1XP_047290800.1  mitochondrial Rho GTPase 2 isoform X2

    3. XM_047434845.1XP_047290801.1  mitochondrial Rho GTPase 2 isoform X3

    4. XM_047434848.1XP_047290804.1  mitochondrial Rho GTPase 2 isoform X5

    5. XM_047434846.1XP_047290802.1  mitochondrial Rho GTPase 2 isoform X3

    6. XM_047434842.1XP_047290798.1  mitochondrial Rho GTPase 2 isoform X2

    7. XM_047434847.1XP_047290803.1  mitochondrial Rho GTPase 2 isoform X4

    8. XM_047434841.1XP_047290797.1  mitochondrial Rho GTPase 2 isoform X1

    9. XM_047434840.1XP_047290796.1  mitochondrial Rho GTPase 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      672158..678249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314282.1XP_054170257.1  mitochondrial Rho GTPase 2 isoform X2

    2. XM_054314283.1XP_054170258.1  mitochondrial Rho GTPase 2 isoform X2

    3. XM_054314284.1XP_054170259.1  mitochondrial Rho GTPase 2 isoform X3

    4. XM_054314287.1XP_054170262.1  mitochondrial Rho GTPase 2 isoform X5

    5. XM_054314285.1XP_054170260.1  mitochondrial Rho GTPase 2 isoform X3

    6. XM_054314281.1XP_054170256.1  mitochondrial Rho GTPase 2 isoform X2

    7. XM_054314286.1XP_054170261.1  mitochondrial Rho GTPase 2 isoform X4

    8. XM_054314280.1XP_054170255.1  mitochondrial Rho GTPase 2 isoform X1

    9. XM_054314279.1XP_054170254.1  mitochondrial Rho GTPase 2 isoform X1