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    ABCC10 ATP binding cassette subfamily C member 10 [ Homo sapiens (human) ]

    Gene ID: 89845, updated on 25-Nov-2021

    Summary

    Official Symbol
    ABCC10provided by HGNC
    Official Full Name
    ATP binding cassette subfamily C member 10provided by HGNC
    Primary source
    HGNC:HGNC:52
    See related
    Ensembl:ENSG00000124574 MIM:612509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRP7; SIMRP7; EST182763
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ABCC10 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43427538..43451994)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43395279..43418165)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 318 Neighboring gene ribosomal protein S2 pseudogene 28 Neighboring gene uncharacterized LOC105375065 Neighboring gene microRNA 6780b Neighboring gene uncharacterized LOC107986597 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene RNA, U6 small nuclear 1113, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukotriene metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukotriene transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane transport TAS
    Traceable Author Statement
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family C member 10
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 10
    multidrug resistance-associated protein 7
    NP_001185863.1
    NP_001337447.1
    NP_258261.2
    XP_011513276.2
    XP_011513287.1
    XP_011513288.1
    XP_016866934.1
    XP_016866935.1
    XP_016866936.1
    XP_016866937.1
    XP_016866938.1
    XP_016866939.1
    XP_016866940.1
    XP_016866942.1
    XP_016866943.1
    XP_016866944.1
    XP_016866945.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198934.2NP_001185863.1  ATP-binding cassette sub-family C member 10 isoform MRP7

      See identical proteins and their annotated locations for NP_001185863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MRP7) encodes the longest isoform (MRP7).
      Source sequence(s)
      AK000002, AL359813, AY032599
      Consensus CDS
      CCDS56430.1
      UniProtKB/Swiss-Prot
      Q5T3U5
      UniProtKB/TrEMBL
      A0A024RD21
      Related
      ENSP00000361608.4, ENST00000372530.9
      Conserved Domains (4) summary
      cd03244
      Location:12441463
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:598801
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:2191469
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:289551
      ABC_membrane; ABC transporter transmembrane region
    2. NM_001350518.2NP_001337447.1  ATP-binding cassette sub-family C member 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform 3.
      Source sequence(s)
      AL359813
      Conserved Domains (1) summary
      cl26602
      Location:81025
      SunT; ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]
    3. NM_033450.3NP_258261.2  ATP-binding cassette sub-family C member 10 isoform MRP7A

      See identical proteins and their annotated locations for NP_258261.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MRP7A), also known as SIMRP7, has multiple differences, compared to variant MRP7. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant MRP7. The encoded protein (isoform MRP7A) is shorter than isoform MRP7.
      Source sequence(s)
      AL359813
      Consensus CDS
      CCDS4896.1
      UniProtKB/Swiss-Prot
      Q5T3U5
      Related
      ENSP00000244533.3, ENST00000244533.7
      Conserved Domains (4) summary
      cd03244
      Location:12161435
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:570773
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      TIGR01271
      Location:1761441
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      cl00549
      Location:246508
      ABC_membrane; ABC transporter transmembrane region

    RNA

    1. NR_146762.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL359813

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      43427538..43451994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011446.2XP_016866935.1  ATP-binding cassette sub-family C member 10 isoform X3

    2. XM_017011447.2XP_016866936.1  ATP-binding cassette sub-family C member 10 isoform X3

    3. XM_017011453.1XP_016866942.1  ATP-binding cassette sub-family C member 10 isoform X7

    4. XM_017011451.1XP_016866940.1  ATP-binding cassette sub-family C member 10 isoform X6

    5. XM_017011449.1XP_016866938.1  ATP-binding cassette sub-family C member 10 isoform X4

    6. XM_017011448.2XP_016866937.1  ATP-binding cassette sub-family C member 10 isoform X4

    7. XM_017011450.2XP_016866939.1  ATP-binding cassette sub-family C member 10 isoform X5

    8. XM_017011445.2XP_016866934.1  ATP-binding cassette sub-family C member 10 isoform X1

    9. XM_011514974.3XP_011513276.2  ATP-binding cassette sub-family C member 10 isoform X2

    10. XM_017011454.2XP_016866943.1  ATP-binding cassette sub-family C member 10 isoform X8

    11. XM_017011455.2XP_016866944.1  ATP-binding cassette sub-family C member 10 isoform X8

    12. XM_011514986.3XP_011513288.1  ATP-binding cassette sub-family C member 10 isoform X9

      See identical proteins and their annotated locations for XP_011513288.1

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region
    13. XM_017011456.2XP_016866945.1  ATP-binding cassette sub-family C member 10 isoform X9

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region
    14. XM_011514985.3XP_011513287.1  ATP-binding cassette sub-family C member 10 isoform X9

      See identical proteins and their annotated locations for XP_011513287.1

      Conserved Domains (4) summary
      cd03244
      Location:593812
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:2150
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      COG4987
      Location:278815
      CydC; ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:308540
      ABC_membrane; ABC transporter transmembrane region

    RNA

    1. XR_002956313.1 RNA Sequence

    2. XR_001743721.1 RNA Sequence

    3. XR_001743722.1 RNA Sequence

    4. XR_001743723.1 RNA Sequence

    5. XR_002956312.1 RNA Sequence

    6. XR_001743720.1 RNA Sequence

    7. XR_001743719.1 RNA Sequence

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