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    ARHGAP11B Rho GTPase activating protein 11B [ Homo sapiens (human) ]

    Gene ID: 89839, updated on 21-Mar-2023

    Summary

    Official Symbol
    ARHGAP11Bprovided by HGNC
    Official Full Name
    Rho GTPase activating protein 11Bprovided by HGNC
    Primary source
    HGNC:HGNC:15782
    See related
    Ensembl:ENSG00000285077 MIM:616310; AllianceGenome:HGNC:15782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B'-T; FAM7B1; GAP (1-8)
    Summary
    Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bone marrow (RPKM 7.6), lymph node (RPKM 4.9) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARHGAP11B in Genome Data Viewer
    Location:
    15q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (30626128..30649229)
    RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (28419321..28443019)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (30918331..30941432)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene 15q13.2-13.3 gamma inversion proximal recombination region Neighboring gene U8 small nucleolar RNA Neighboring gene ARHGAP11B divergent transcript Neighboring gene ULK4 pseudogene 2 Neighboring gene 15q13 proximal microdeletion recombination region Neighboring gene golgin A8 family member H Neighboring gene RNA, 7SL, cytoplasmic 628, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:30917238-30918231 Neighboring gene OTU deubiquitinase 7A pseudogene Neighboring gene proximal CHRNA7 low-copy repeat recombination region Neighboring gene putative golgin subfamily A member 8I Neighboring gene RNA, 7SL, cytoplasmic 82, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC104367

    General protein information

    Preferred Names
    inactive Rho GTPase-activating protein 11B
    Names
    family with sequence similarity 7, member B1
    rho GTPase-activating protein 11B
    rho-type GTPase-activating protein 11B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039841.3NP_001034930.1  inactive Rho GTPase-activating protein 11B

      See identical proteins and their annotated locations for NP_001034930.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC091057, AL556699, BC105788
      Consensus CDS
      CCDS32185.1
      UniProtKB/Swiss-Prot
      Q3KRB8
      Related
      ENSP00000513489.1, ENST00000697964.2
      Conserved Domains (1) summary
      cd04394
      Location:46226
      RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...

    RNA

    1. NR_148423.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC091057

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      30626128..30649229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332701.1 Reference GRCh38.p14 PATCHES

      Range
      2798623..2822311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_012132920.1 Reference GRCh38.p14 PATCHES

      Range
      1878743..1902434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187660.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      2911075..2934763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      28419321..28443019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)