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    H3C7 H3 clustered histone 7 [ Homo sapiens (human) ]

    Gene ID: 8968, updated on 17-Jun-2024

    Summary

    Official Symbol
    H3C7provided by HGNC
    Official Full Name
    H3 clustered histone 7provided by HGNC
    Primary source
    HGNC:HGNC:4773
    See related
    Ensembl:ENSG00000277775 MIM:602816; AllianceGenome:HGNC:4773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H3/i; H3C1; H3C2; H3C3; H3C4; H3C6; H3C8; H3FI; H3C10; H3C11; H3C12; HIST1H3F
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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    Genomic context

    See H3C7 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26250142..26250635, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26118613..26119106, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26250370..26250863, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24219 Neighboring gene H4 clustered histone 6 Neighboring gene H4 clustered histone 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24222 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26251592-26252322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24225 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26253831-26254332 Neighboring gene H2B clustered histone 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:26254333-26254832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24226 Neighboring gene uncharacterized LOC105374986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17002

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding HDA PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nucleosome IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H3.1
    Names
    H3 histone family, member I
    histone 1, H3f
    histone H3/i
    histone cluster 1 H3 family member f
    histone cluster 1, H3f

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021018.3NP_066298.1  histone H3.1

      See identical proteins and their annotated locations for NP_066298.1

      Status: REVIEWED

      Source sequence(s)
      AL031777
      Consensus CDS
      CCDS4600.1
      UniProtKB/Swiss-Prot
      A0PJT7, A5PLR1, P02295, P02296, P16106, P68431, Q6ISV8, Q6NWP8, Q6NWP9, Q6NXU4, Q71DJ3, Q93081
      UniProtKB/TrEMBL
      A8K4Y7, B2R6Y1
      Related
      ENSP00000484095.2, ENST00000618052.2
      Conserved Domains (1) summary
      PTZ00018
      Location:1136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26250142..26250635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26118613..26119106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)