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    VNN1 vanin 1 [ Homo sapiens (human) ]

    Gene ID: 8876, updated on 5-Mar-2024

    Summary

    Official Symbol
    VNN1provided by HGNC
    Official Full Name
    vanin 1provided by HGNC
    Primary source
    HGNC:HGNC:12705
    See related
    Ensembl:ENSG00000112299 MIM:603570; AllianceGenome:HGNC:12705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HDLCQ8; Tiff66
    Summary
    This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
    Expression
    Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues See more
    Orthologs
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    Genomic context

    See VNN1 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132680849..132714055, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133875818..133909022, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133001988..133035194, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17552 Neighboring gene trace amine associated receptor 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:133004442-133005641 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89871 Neighboring gene HLF pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_89876 Neighboring gene cyclin G1 pseudogene 1 Neighboring gene vanin 3, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:133069914-133071113 Neighboring gene vanin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25074

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC116930, MGC116931, MGC116932, MGC116933

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables pantetheine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pantetheine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantetheine hydrolase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in acute inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in chronic inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in coenzyme A catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in pantothenate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pantothenate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pantothenate metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pantetheinase
    Names
    pantetheine hydrolase
    vannin 1
    vascular non-inflammatory molecule 1
    NP_004657.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012147.1 RefSeqGene

      Range
      5001..38207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004666.3NP_004657.2  pantetheinase precursor

      See identical proteins and their annotated locations for NP_004657.2

      Status: REVIEWED

      Source sequence(s)
      AL032821, BC096266, BJ995136
      Consensus CDS
      CCDS5159.1
      UniProtKB/Swiss-Prot
      A8K310, O95497, Q4JFW6, Q4VAS7, Q4VAS8, Q4VAS9, Q9UF16, Q9UJF4
      UniProtKB/TrEMBL
      B2RAN2
      Related
      ENSP00000356905.4, ENST00000367928.5
      Conserved Domains (1) summary
      cd07567
      Location:25330
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132680849..132714055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133875818..133909022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)