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    CFLAR CASP8 and FADD like apoptosis regulator [ Homo sapiens (human) ]

    Gene ID: 8837, updated on 17-Jun-2024

    Summary

    Official Symbol
    CFLARprovided by HGNC
    Official Full Name
    CASP8 and FADD like apoptosis regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:1876
    See related
    Ensembl:ENSG00000003402 MIM:603599; AllianceGenome:HGNC:1876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CASH; FLIP; MRIT; CLARP; FLAME; cFLIP; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
    Summary
    The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in fat (RPKM 11.3), bone marrow (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CFLAR in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201116164..201176687)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (201599606..201660139)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201980887..202041410)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1206, pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 Neighboring gene uncharacterized LOC105373836 Neighboring gene ribosomal protein L17 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:201983171-201983674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12230 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:201988912-201989135 Neighboring gene NANOG hESC enhancer GRCh37_chr2:201989404-201989905 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:201990328-201990574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202002357-202003313 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202003314-202004270 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202004271-202005227 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 10 Neighboring gene CFLAR antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202014382-202015067 Neighboring gene RNA, U7 small nuclear 45 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:202015298-202016497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16980 Neighboring gene RPL38 pseudogene 5 Neighboring gene caspase 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16981 Neighboring gene MT-ND5 pseudogene 25 Neighboring gene MT-ND4L pseudogene 13 Neighboring gene MT-ND4 pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of CASP8 and FADD-like apoptosis regulator (CFLAR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Trafficking of HIV-1 gp120 to lipid rafts is blocked by expression of cFLIP PubMed
    env HIV-1 Env-pseudotyped virus-infected monocyte-derived macrophage cells downregulate expression of TRAIL decoy receptors DcR1 and DcR2, and cellular FLICE-inhibitory protein (c-FLIP) PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    capsid gag cFLIP-induced upregulation of TRIM-5alpha expression inhibits HIV-1 CA expression PubMed
    gag Trafficking of HIV-1 CA to lipid rafts is blocked by expression of cFLIP, which causes decreased levels of TSG101 and Alix at the plasma membrane PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables death receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glomerular mesangial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of skeletal muscle satellite cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle atrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal muscle tissue regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in skeletal myofibril assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ripoptosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    FADD-like antiapoptotic molecule 1
    MACH-related inducer of toxicity
    caspase homolog
    caspase-eight-related protein
    caspase-like apoptosis regulatory protein
    caspase-related inducer of apoptosis
    cellular FLICE-like inhibitory protein
    inhibitor of FLICE
    testis secretory sperm-binding protein Li 233m
    usurpin beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029005.2 RefSeqGene

      Range
      5002..65525
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127183.4NP_001120655.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001120655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS2337.1
      UniProtKB/Swiss-Prot
      B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
      UniProtKB/TrEMBL
      A0A024R3Y4, A0A024R3Z7
      Related
      ENSP00000399420.2, ENST00000423241.6
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. NM_001127184.4NP_001120656.1  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_001120656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate coding exon that results in a shorter protein isoform (2) with a distinct C-terminus. Variants 3, 12, and 13 all encode the same isoform (2).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS46487.1
      UniProtKB/TrEMBL
      B4DMB6
      Related
      ENSP00000339335.6, ENST00000341222.10
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    3. NM_001202515.1NP_001189444.1  CASP8 and FADD-like apoptosis regulator isoform 3

      See identical proteins and their annotated locations for NP_001189444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC007283, AF041459, BM969271
      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (1) summary
      smart00115
      Location:1234
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    4. NM_001202516.3NP_001189445.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001189445.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56157.1
      Related
      ENSP00000345807.6, ENST00000341582.10
      Conserved Domains (3) summary
      smart00115
      Location:209444
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    5. NM_001202517.3NP_001189446.1  CASP8 and FADD-like apoptosis regulator isoform 5

      See identical proteins and their annotated locations for NP_001189446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 14, and 15 all encode the same isoform (5).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56158.1
      UniProtKB/TrEMBL
      B4E361
      Related
      ENSP00000413270.1, ENST00000443227.5
      Conserved Domains (2) summary
      smart00115
      Location:148383
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. NM_001202518.2NP_001189447.1  CASP8 and FADD-like apoptosis regulator isoform 6

      See identical proteins and their annotated locations for NP_001189447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
      Source sequence(s)
      AC007283, AK304585, BM969271, CD699251
      Consensus CDS
      CCDS59436.1
      UniProtKB/TrEMBL
      B4E361
      Related
      ENSP00000471805.1, ENST00000479953.6
      Conserved Domains (2) summary
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:148337
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    7. NM_001202519.3NP_001189448.1  CASP8 and FADD-like apoptosis regulator isoform 6

      See identical proteins and their annotated locations for NP_001189448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS59436.1
      UniProtKB/TrEMBL
      B4E361
      Conserved Domains (2) summary
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:148337
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    8. NM_001308042.3NP_001294971.1  CASP8 and FADD-like apoptosis regulator isoform 7

      See identical proteins and their annotated locations for NP_001294971.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and contains an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and distinct 3' UTR. The resulting isoform (7) is shorter and has a distinct C-terminus compared to isoform 1. Variants 9 and 11 both encode the same isoform (7).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS77505.1
      UniProtKB/TrEMBL
      A0A336TY74
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    9. NM_001308043.2NP_001294972.1  CASP8 and FADD-like apoptosis regulator isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks multiple exons in the central and 3' coding regions, and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (8) is significantly shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB209600, AC007283, DC375144
      Consensus CDS
      CCDS77503.1
      UniProtKB/TrEMBL
      E9PAP3, Q59F61
      Related
      ENSP00000378580.2, ENST00000395148.6
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    10. NM_001351590.2NP_001338519.1  CASP8 and FADD-like apoptosis regulator isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 9, encodes isoform 7.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS77505.1
      UniProtKB/TrEMBL
      A0A336TY74
      Related
      ENSP00000411535.1, ENST00000457277.5
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    11. NM_001351591.2NP_001338520.1  CASP8 and FADD-like apoptosis regulator isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3 and 13, encodes isoform 2.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS46487.1
      UniProtKB/TrEMBL
      B4DMB6
      Related
      ENSP00000406775.1, ENST00000440180.5
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    12. NM_001351592.2NP_001338521.1  CASP8 and FADD-like apoptosis regulator isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3 and 12, encodes isoform 2.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS46487.1
      UniProtKB/TrEMBL
      B4DMB6
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    13. NM_001351593.2NP_001338522.1  CASP8 and FADD-like apoptosis regulator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 6 and 15, encodes isoform 5.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56158.1
      UniProtKB/TrEMBL
      B4E361
      Conserved Domains (2) summary
      smart00115
      Location:148383
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    14. NM_001351594.2NP_001338523.1  CASP8 and FADD-like apoptosis regulator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 6 and 14, encodes isoform 5.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56158.1
      UniProtKB/TrEMBL
      B4E361
      Conserved Domains (2) summary
      smart00115
      Location:148383
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    15. NM_003879.7NP_003870.4  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_003870.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate first exon and encodes the longest protein isoform (1). Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS2337.1
      UniProtKB/Swiss-Prot
      B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
      UniProtKB/TrEMBL
      A0A024R3Y4, A0A024R3Z7
      Related
      ENSP00000312455.2, ENST00000309955.8
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RNA

    1. NR_147241.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    2. NR_147242.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    3. NR_147243.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    4. NR_147244.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    5. NR_147245.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    6. NR_147246.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    7. NR_147247.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    8. NR_147248.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    9. NR_147249.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    10. NR_147250.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    11. NR_147251.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    12. NR_147252.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    13. NR_147253.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    14. NR_147255.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      201116164..201176687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446185.1XP_047302141.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/Swiss-Prot
      B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
      UniProtKB/TrEMBL
      A0A024R3Y4, A0A024R3Z7
    2. XM_047446197.1XP_047302153.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/TrEMBL
      B4DMB6
    3. XM_047446191.1XP_047302147.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      B4E361

    RNA

    1. XR_001739013.3 RNA Sequence

    2. XR_007083713.1 RNA Sequence

    3. XR_007083702.1 RNA Sequence

    4. XR_007083735.1 RNA Sequence

      Related
      ENST00000342795.9
    5. XR_007083742.1 RNA Sequence

    6. XR_007083723.1 RNA Sequence

    7. XR_007083715.1 RNA Sequence

    8. XR_007083684.1 RNA Sequence

    9. XR_007083740.1 RNA Sequence

    10. XR_007083755.1 RNA Sequence

    11. XR_007083745.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      201599606..201660139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344371.1XP_054200346.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/Swiss-Prot
      B4DJE0, B7Z9F9, O14673, O14674, O14675, O15137, O15138, O15356, O15510, O15519, O43618, O43619, O43620, O60458, O60459, Q53TS6, Q54AF1, Q96TE4, Q9UEW1
      UniProtKB/TrEMBL
      A0A024R3Y4, A0A024R3Z7
    2. XM_054344375.1XP_054200350.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/TrEMBL
      B4DMB6
    3. XM_054344374.1XP_054200349.1  CASP8 and FADD-like apoptosis regulator isoform X4

      UniProtKB/TrEMBL
      E9PAP3, Q59F61
    4. XM_054344373.1XP_054200348.1  CASP8 and FADD-like apoptosis regulator isoform X4

      UniProtKB/TrEMBL
      E9PAP3, Q59F61
    5. XM_054344372.1XP_054200347.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/TrEMBL
      B4E361

    RNA

    1. XR_008486584.1 RNA Sequence

    2. XR_008486585.1 RNA Sequence

    3. XR_008486583.1 RNA Sequence

    4. XR_008486588.1 RNA Sequence

    5. XR_008486587.1 RNA Sequence

    6. XR_008486586.1 RNA Sequence

    7. XR_008486582.1 RNA Sequence

    8. XR_008486589.1 RNA Sequence